Diverse actions of added alkanols on the binding of dibucaine cation to an anionic polymer

  • Keishiro Shirahama
  • Hideyuki Koga
  • Noboru Takisawa
Conference paper
Part of the Progress in Colloid and Polymer Science book series (PROGCOLLOID, volume 122)


The binding of dibucaine cation to a polyanion [poly(acrylamide 2-methylpropane sulfonate)] in the presence of various alkanols(C1C3, C5, and C7) is measured by using an electrode responsive to dibucaine cation. The binding is characteristic of cooperative interaction. The binding affinity is enhanced by added pentanol and heptanol, and is well correlated with thermodynamic activities of these alkanols. In contrast, methanol and ethanol reduce the binding affinity, which is well correlated with the free energy of transfer of dibucaine cation from water to mixed solvent. The effect of added propanol lies between the medium- and the small-chain alkanols. The significance of the present results is briefly referred to in relation with the solution state of dibucaine in a body fluid.


Dibucaine Selective electrode Anionic polymer Binding isotherm Alkanols 


Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.


  1. 1.
    Steiner RF, Garone L (1991) The physical chemistry of biopolymer solutions. World Scientific, LondonGoogle Scholar
  2. 2.
    Liu J, Takisawa N, Shirahama K (1999) Colloid Polym Sci 277:247CrossRefGoogle Scholar
  3. 3.
    Shirahama K, Liu J, Takisawa N (1999) Colloids Surf A 147:133CrossRefGoogle Scholar
  4. 4.
    Shirahama K (1998) In: Kwak JCT (ed) Polymer-surfactant systems, vol 77. Dekker, New York, pp 143–191Google Scholar
  5. 5.
    Satake I, Yang JT (1976) Biopolymers 15:2263CrossRefGoogle Scholar

Copyright information

© Springer-Verlag 2003

Authors and Affiliations

  • Keishiro Shirahama
    • 1
    • 2
  • Hideyuki Koga
    • 1
  • Noboru Takisawa
    • 1
  1. 1.Fukuoka CityJapan
  2. 2.Department of Chemistry and Applied ChemistrySaga UniversitySagaJapan

Personalised recommendations