Skip to main content
SpringerLink
Log in

Total Body Irradiation Conditioning Regimens in Stem Cell Transplantation

  • Chapter
Technical Basis of Radiation Therapy

Part of the book series: Medical Radiology ((Med Radiol Radiat Oncol))

This is a preview of subscription content, log in via an institution to check access.

Access this chapter

Log in via an institution
Chapter
USD 29.95
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
eBook
USD 109.00
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever

Tax calculation will be finalised at checkout

Purchases are for personal use only

Institutional subscriptions

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

References

  • AAPM, American Association of Physicists in Medicine (task Group 2) (1986) The physical aspects of total and half body photon irradiation. AAPM Report no 17

    Google Scholar 

  • Abraham R et al. (1999) Intensification of the stem cell transplant induction regimen results in increased treatment-related mortality without improved outcome in multiple myeloma. Bone Marrow Transplant 24:1291–1297

    Article  PubMed  CAS  Google Scholar 

  • Almond PR et al. (1999) AAPM’s TG-51 protocol for clinical reference dosimetry of high-energy photon and electron beams. Med Phys 26:1847

    Article  PubMed  CAS  Google Scholar 

  • Aristei C et al. (2002) Cataracts in patients receiving stem cell transplantation after conditioning with total body irradiation. Bone Marrow Transplant 29:503–507

    Article  PubMed  CAS  Google Scholar 

  • Auner HW et al. (2002) Infectious complications after autologous hematopoietic stem cell transplantation: comparison of patients with acute myeloid leukemia, malignant lymphoma, and multiple myeloma. Ann Hematol 81:374–377

    Article  PubMed  CAS  Google Scholar 

  • Beavis AW (2004) Is tomotherapy the future of IMRT? Br J Radiol 77:285–295

    Article  PubMed  CAS  Google Scholar 

  • Bhatia S et al. (1996) Malignant neoplasms following bone marrow transplantation. Blood 87:3633–3639

    PubMed  CAS  Google Scholar 

  • Cardozo BL et al. (1985) Lung damage following bone marrow transplantation: I. the contribution of irradiation. Int J Radiat Oncol Biol Phys 11:907–914

    PubMed  CAS  Google Scholar 

  • Carlson K et al. (1994) Pulmonary function and complications subsequent to autologous bone marrow transplantation. Bone Marrow Transplant 14:805–811

    PubMed  CAS  Google Scholar 

  • Carruthers SA, Wallington MM (2004) Total body irradiation and pneumonitis risk: a review of outcomes. Br J Cancer 90:2080–2084

    PubMed  CAS  Google Scholar 

  • Cole CH et al. (1994) Intensive conditioning regimen for bone marrow transplantation in children with high-risk haematological malignancies. Med Pediatr Oncol 23:464–469

    PubMed  CAS  Google Scholar 

  • Colombat P et al. (2000) Value of autologous stem cell transplantation with purged bone marrow as first-line therapy for follicular lymphoma with high tumor burden: a GOELAMS phase II study. Bone Marrow Transplant 26:971–977

    Article  PubMed  CAS  Google Scholar 

  • Cornetta K et al. (2005) Umbilical cord blood transplantation in adults: results of the prospective Cord Blood Transplantation (COBLT). Biol Blood Marrow Transplant 11:149–160

    Article  PubMed  Google Scholar 

  • Cowen D et al. (1992) Regimen-related toxicity in patients undergoing BMT with total body irradiation using a sweeping beam technique. Bone Marrow Transplant 10:515–519

    PubMed  CAS  Google Scholar 

  • Dusenbery KE et al. (1996) Autologous bone marrow transplantation in acute myeloid leukemia: the University of Minnesota experience. Int J Radiat Oncol Biol Phys 36:335–343

    Article  PubMed  CAS  Google Scholar 

  • Emmanouilides C et al. (2003) Localized radiation increases morbidity and mortality after TBI-containing autologous stem cell transplantation in patients with lymphoma. Bone Marrow Transplant 32:863–867

    Article  PubMed  CAS  Google Scholar 

  • Emminger W et al. (1991) Is treatment intensification by adding etoposide and carboplatin to fractionated total body irradiation and melphalan acceptable in children with solid tumors with respect to toxicity? Bone Marrow Transplant 8:119–123

    PubMed  CAS  Google Scholar 

  • Faraci M et al. (2002) Severe neurologic complications after hematopoietic stem cell transplantation in children. Neurology 59:1895–1904 [erratum (2003) 60:1055]

    PubMed  CAS  Google Scholar 

  • Fehr T, Sykes M (2004) Tolerance induction in clinical transplantation. Transplant Immunology 13(2): p. 117–30.

    Article  PubMed  CAS  Google Scholar 

  • Freedman AS et al. (1998) High-dose chemoradiotherapy and anti-B-cell monoclonal antibody-purged autologous bone marrow transplantation in mantle-cell lymphoma: no evidence for long-term remission (comment). J Clin Oncol 16:13–18

    PubMed  CAS  Google Scholar 

  • Gatti RA et al. (1968) Immunological reconstitution of sex-linked lymphopenic immunological deficiency. Lancet 2:1366–1369

    Article  PubMed  CAS  Google Scholar 

  • Hall EJ (1994) Radiobiology for the radiologist, 4th edn. J.B. Lippincott, Philadelphia. xii, p 478

    Google Scholar 

  • Hawley RG et al. (1996) Retroviral vectors for production of interleukin-12 in the bone marrow to induce a graftversus-leukemia effect. Ann NY Acad Sci 795:341–345

    PubMed  CAS  Google Scholar 

  • Heslop HE, Rooney CM, Brenner MK (1995) Gene-marking and haemopoietic stem-cell transplantation. Blood Rev 9:220–225

    Article  PubMed  CAS  Google Scholar 

  • Iannone R et al. (2003) Results of minimally toxic nonmyeloablative transplantation in patients with sickle cell anemia and beta-thalassemia. Biol Blood Marrow Transplant 9:519–528

    Article  PubMed  Google Scholar 

  • Imamura M, Hashino S, Tanaka J (1996) Graft-versus-leukemia effect and its clinical implications. Leuk Lymphoma 23:477–492

    PubMed  CAS  Google Scholar 

  • Karanes C (2003) Unrelated donor stem cell transplant: donor selection and search process. Pediatr Transplant 7[Suppl 3]:59–64

    Article  PubMed  Google Scholar 

  • Khan FM, Moore VC, Burns DJ (1970) The construction of compensators for cobalt teletherapy. Radiology 96:187–192

    PubMed  CAS  Google Scholar 

  • Khan FM et al. (1980) Basic data for dosage calculation and compensation. Int J Radiat Oncol Biol Phys 6:745–751

    PubMed  CAS  Google Scholar 

  • Kim TH et al. (1985) Interstitial pneumonitis following total body irradiation for bone marrow transplantation using two different dose rates. Int J Radiat Oncol Biol Phys 11:1285–1291

    PubMed  CAS  Google Scholar 

  • Kirby TH, Hanson WF, Cates DA (1988) Verification of total body photon irradiation dosimetry techniques. Med Phys 15:364–369

    Article  PubMed  CAS  Google Scholar 

  • Klingemann HG (1996) Role of postinduction immunotherapy in acute myeloid leukemia. Leukemia 10[Suppl 1]:S21–S22

    PubMed  Google Scholar 

  • Korbling M et al. (1991) Autologous blood stem cell (ABSCT) versus purged bone marrow transplantation (pABMT) in standard risk AML: influence of source and cell composition of the autograft on hemopoietic reconstitution and disease-free survival. Bone Marrow Transplant 7:343–349

    PubMed  CAS  Google Scholar 

  • Krishnamurti L et al. (2003) Availability of unrelated donors for hematopoietic stem cell transplantation for hemoglobinopathies. Bone Marrow Transplant 31:547–550

    Article  PubMed  CAS  Google Scholar 

  • Lane PH et al. (1994) Outcome of dialysis for acute renal failure in pediatric bone marrow transplant patients. Bone Marrow Transplant 13:613–617

    PubMed  CAS  Google Scholar 

  • Lawton CA et al. (1989) Technical modifications in hyperfractionated total body irradiation for T-lymphocyte deplete bone marrow transplant. Int J Radiat Oncol Biol Phys 17:319–322

    PubMed  CAS  Google Scholar 

  • Lawton CA et al. (1992) Influence of renal shielding on the incidence of late renal dysfunction associated with T-lymphocyte deplete bone marrow transplantation in adult patients. Int J Radiat Oncol Biol Phys 23:681–686

    PubMed  CAS  Google Scholar 

  • Leshem B, Vourka-Karussis U, Slavin S (2000) Correlation between enhancement of graft-versus-leukemia effects following allogeneic bone marrow transplantation by rIL-2 and increased frequency of cytotoxic T-lymphocyte precursors in murine myeloid leukemia. Cytokines Cell Mol Ther 6:141–147

    PubMed  CAS  Google Scholar 

  • Mackie TR et al. (2003) Image guidance for precise conformal radiotherapy. Int J Radiat Oncol Biol Phys 56:89–105

    Article  PubMed  Google Scholar 

  • Mahmoud HK et al. (1985) Bone marrow transplantation for chronic granulocytic leukaemia. Klin Wochenschr 63:560–564

    Article  PubMed  CAS  Google Scholar 

  • McCullough J et al. (1989) The National Marrow Donor Program: how it works, accomplishments to date. Oncology (Huntingt) 3:63–68

    PubMed  CAS  Google Scholar 

  • Miralbell R et al. (1996) Renal toxicity after allogeneic bone marrow transplantation: the combined effects of total-body irradiation and graft-versus-host disease. J Clin Oncol 14:579–585

    PubMed  CAS  Google Scholar 

  • Molls M, Budach V, Bamberg M (1986) Total body irradiation: the lung as critical organ. Strahlentherapie und Onkologie 162:226–232

    PubMed  CAS  Google Scholar 

  • Moulder JE, Fish BL (1989) Late toxicity of total body irradiation with bone marrow transplantation in a rat model. Int J Radiat Oncol Biol Phys 16:1501–1509

    PubMed  CAS  Google Scholar 

  • Moulder JE, Fish BL (1991) Influence of nephrotoxic drugs on the late renal toxicity associated with bone marrow transplant conditioning regimens. Int J Radiat Oncol Biol Phys 20:333–337

    PubMed  CAS  Google Scholar 

  • Moulder JE, Fish BL, Abrams RA (1987) Renal toxicity following total-body irradiation and syngeneic bone marrow transplantation. Transplantation 43:589–592

    Article  PubMed  CAS  Google Scholar 

  • Moulder JE, Fish BL, Holcenberg JS, Cheng M (1988) Effect of total-body irradiation with bone marrow transplantation on toxicity of cisplatin. NCI Monogr 6:29–33

    PubMed  Google Scholar 

  • Parr MD, Messino MJ, McIntyre W (1991) Allogeneic bone marrow transplantation: procedures and complications. Am J Hospital Pharmacy 48:127–137

    CAS  Google Scholar 

  • Peters C et al. (2003) Hematopoietic cell transplantation for inherited metabolic diseases: an overview of outcomes and practice guidelines. Bone Marrow Transplant 31:229–239

    Article  PubMed  CAS  Google Scholar 

  • Petersdorf E et al. (1998) Effect of HLA matching on outcome of related and unrelated donor transplantation therapy for chronic myelogenous leukemia. Hematol Oncol Clin North Am 12:107–121

    Article  PubMed  CAS  Google Scholar 

  • Quaranta BP et al. (2004) The incidence of testicular recurrence in boys with acute leukemia treated with total body and testicular irradiation and stem cell transplantation. Cancer 101:845–850

    Article  PubMed  Google Scholar 

  • Remberger M et al. (2002) The graft-versus-leukaemia effect in haematopoietic stem cell transplantation using unrelated donors. Bone Marrow Transplant 30:761–768

    Article  PubMed  CAS  Google Scholar 

  • Rubin J et al. (2005) Acute neurological complications after hematopoietic stem cell transplantation in children. Pediatr Transplant 9:62–67

    Article  PubMed  Google Scholar 

  • Schleuning M (2000) Adoptive allogeneic immunotherapy — history and future perspectives. Transfusion Sci 23:133–150

    Article  CAS  Google Scholar 

  • Schouten HC et al. (2000) The CUP trial: a randomized study analyzing the efficacy of high dose therapy and purging in low-grade non-Hodgkin’s lymphoma (NHL). Ann Oncol 11[Suppl 1]:91–94

    Article  PubMed  Google Scholar 

  • Shank B et al. (1983) Hyperfractionated total body irradiation for bone marrow transplantation. Results in seventy leukemia patients with allogeneic transplants. Int J Radiat Oncol Biol Phys 9:1607–1611

    PubMed  CAS  Google Scholar 

  • Standke E (1989) Fundamentals, trends and our experiences with total body irradiation (TBI) before bone marrow transplantation (BMT). Folia Haematologica — Internationales Magazin fur Klinische und Morphologische Blutforschung 116:481–485

    CAS  Google Scholar 

  • Steingrimsdottir H et al. (2000) Immune reconstitution after autologous hematopoietic stem cell transplantation in relation to underlying disease, type of high-dose therapy and infectious complications. Haematologica 85:832–838

    PubMed  CAS  Google Scholar 

  • Storek J et al. (2003) Interleukin-7 improves CD4 T-cell reconstitution after autologous CD34 cell transplantation in monkeys. Blood 101:4209–4218

    Article  PubMed  CAS  Google Scholar 

  • Thomas ED (1997) Pros and cons of stem cell transplantation for autoimmune disease. J Rheumatol 48[Suppl]:100–102

    CAS  Google Scholar 

  • Valls A et al. (1989) Total body irradiation in bone marrow transplantation: fractionated vs single dose. Acute toxicity and preliminary results. Bulletin du Cancer 76:797–804

    PubMed  CAS  Google Scholar 

  • van Besien K et al. (2003) Comparison of autologous and allogeneic hematopoietic stem cell transplantation for follicular lymphoma. Blood 102:3521–3529

    Article  PubMed  CAS  Google Scholar 

  • Van Dyk J, Keane TJ, Rider WD (1982) Lung density as measured by computerized tomography: implications for radiotherapy. Int J Radiat Oncol Biol Phys 8:1363

    PubMed  Google Scholar 

  • Wood KJ, Prior TG (2001) Gene therapy in transplantation. Curr Opin Mol Therapeut 3:390–398

    CAS  Google Scholar 

  • Zecca M et al. (2002) Chronic graft-versus-host disease in children: incidence, risk factors, and impact on outcome. Blood 100:1192–1200

    Article  PubMed  CAS  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Department of Radiation Oncology, University of Minnesota Medical School, MMC436, 420 Delaware St. S.E., Minneapolis, MN, 55455, USA

    Kathryn E. Dusenbery MD

  2. Therapeutic Radiology — Radiation Oncology, University of Minnesota, Mayo Mail Code 494, 420 Delaware St SE, Minneapolis, MN, 55455, USA

    Bruce J. Gerbi PhD (Associate Professor)

Authors
  1. Kathryn E. Dusenbery MD
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Bruce J. Gerbi PhD
    View author publications

    You can also search for this author in PubMed Google Scholar

Editor information

Editors and Affiliations

  1. Department of Therapeutic Radiation, Oncology MMC 436, University of Minnesota Hospital, 420 Delaware St SE, Minneapolis, MN, 55455, USA

    Seymour H. Levitt MD (Professor and Foreign Adjunct Professor) (Professor and Foreign Adjunct Professor)

  2. Karolinska Institute Stockholm, Sweden

    Seymour H. Levitt MD (Professor and Foreign Adjunct Professor) (Professor and Foreign Adjunct Professor)

  3. Department of Radiation Oncology, UC Davis Medical Center, 4501 X Street, Suite G140, Sacramento, CA, 95817, USA

    James A. Purdy PhD (Professor, Vice Chairman and Chief) (Professor, Vice Chairman and Chief)

  4. Physics Section, UC Davis Medical Center, 4501 X Street, Suite G140, Sacramento, CA, 95817, USA

    James A. Purdy PhD (Professor, Vice Chairman and Chief) (Professor, Vice Chairman and Chief)

Rights and permissions

Reprints and permissions

Copyright information

© 2006 Springer-Verlag Berlin Heidelberg

About this chapter

Cite this chapter

Dusenbery, K.E., Gerbi, B.J. (2006). Total Body Irradiation Conditioning Regimens in Stem Cell Transplantation. In: Levitt, S.H., Purdy, J.A. (eds) Technical Basis of Radiation Therapy. Medical Radiology. Springer, Berlin, Heidelberg . https://doi.org/10.1007/3-540-35665-7_31

Download citation

  • DOI: https://doi.org/10.1007/3-540-35665-7_31

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-540-21338-3

  • Online ISBN: 978-3-540-35665-3

  • eBook Packages: MedicineMedicine (R0)

Publish with us

Policies and ethics

Search

Navigation