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Radiation Therapy for Cervical Cancer

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Book cover Technical Basis of Radiation Therapy

Part of the book series: Medical Radiology ((Med Radiol Radiat Oncol))

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References

  • Adcock LL et al. (1984) Carcinoma of the cervix, FIGO Stage IB: treatment failures. Gynecol Oncol 18:218–225

    Article  PubMed  CAS  Google Scholar 

  • Au WW, Sierra-Torres CH, Tyring SK (2003) Acquired and genetic susceptibility to cervical cancer. Mutation Res 544:361–364

    Article  PubMed  CAS  Google Scholar 

  • Belinson JL, Doherty M, McDay JB (1984) A new technique for ovarian transposition. Surg Gynecol Obstet 159:157–160

    PubMed  CAS  Google Scholar 

  • Bhatnagar JP, Kaplan C, Specht R (1980) A rule of thumb for dose rate at point A for the Fletcher-Suit applicator. Br J Radiol 53:511–512

    Article  PubMed  CAS  Google Scholar 

  • Chen RJ et al. (1999) Influence of histologic type and age on survival rates for invasive cervical carcinoma in Taiwan. Gynecol Oncol 73:184–190

    Article  PubMed  CAS  Google Scholar 

  • Coia L et al. (1990) The patterns of care outcome study for cancer of the uterine cervix. Results of the Second National Practice Survey. Cancer 66:2451–2456

    Article  PubMed  CAS  Google Scholar 

  • Committee on Practice (2002) B.-G., ACOG practice bulletin. Diagnosis and treatment of cervical carcinomas, number 35, May 2002. Obstet Gynecol 99:855–867

    Google Scholar 

  • Cosin JA et al. (1998) Pretreatment surgical staging of patients with cervical carcinoma: the case for lymph node debulking. Cancer 82:2241–2248

    Article  PubMed  CAS  Google Scholar 

  • Crook JM et al. (1987) Dose-volume analysis and the prevention of radiation sequelae in cervical cancer. Radiother Oncol 8:321–332

    PubMed  CAS  Google Scholar 

  • Deore SM et al. (1991) The severity of late rectal and rectosigmoid complications related to fraction size in irradiation treatment of carcinoma cervix stage III B. Strahlenther Onkol 167:638–642

    PubMed  CAS  Google Scholar 

  • Dunleavey R (2004) Incidence, pathophysiology and treatment of cervical cancer. Nursing Times 100:38–41

    PubMed  Google Scholar 

  • Dunst J et al. (2003) Anemia in cervical cancers: impact on survival, patterns of relapse, and association with hypoxia and angiogenesis. Int J Radiation Oncol Biol Phys 56:778–787

    Article  Google Scholar 

  • Eifel PJ et al. (1990) Adenocarcinoma of the uterine cervix. Prognosis and patterns of failure in 367 cases. Cancer 65:2507–2514

    Article  PubMed  CAS  Google Scholar 

  • Eifel PJ et al. (1995) Time course and incidence of late complications in patients treated with radiation therapy for FIGO stage IB carcinoma of the uterine cervix. Int J Radiat Oncol Biol Phys 32:1289–1300

    Article  PubMed  CAS  Google Scholar 

  • Erridge SC et al. (2002) The effect of overall treatment time on the survival and toxicity of radical radiotherapy for cervical carcinoma. Radiother Oncol 63:59–66

    Article  PubMed  Google Scholar 

  • Esche BA et al. (1987) Reference volume, milligram-hours and external irradiation for the Fletcher applicator. Radiother Oncol. 9:255–261

    PubMed  CAS  Google Scholar 

  • Fey MC and Beal MW (2004) Role of human papilloma virus testing in cervical cancer prevention. J Midwifery Women’s Health 49:4–13

    Article  Google Scholar 

  • Fletcher GH (1973) Female pelvis: squamous cell carcinoma of the uterine cervix. In: Fletcher GH (ed) Textbook of radiotherapy. Saunders, London, p 620

    Google Scholar 

  • Gasinska A et al. (2002) Prognostic significance of intratumour microvessel density and haemoglobin level in carcinoma of the uterine cervix. Acta Oncologica 41:437–443

    Article  PubMed  Google Scholar 

  • Gerbaulet AL et al. (1992) Combined radiotherapy and surgery: local control and complications in early carcinoma of the uterine cervix-the Villejuif experience, 1975–1984. Radiother Oncol 23:66–73

    Article  PubMed  CAS  Google Scholar 

  • Ghosh K et al. (2001) Using a belly board device to reduce the small bowel volume within pelvic radiation fields in women with postoperatively treated cervical carcinoma. Gynecol Oncol 83:271–275

    Article  PubMed  CAS  Google Scholar 

  • Greven K et al. (1999) Current developments in the treatment of newly diagnosed cervical cancer. Hematol Oncol Clin North Am 13:275–303

    Article  PubMed  CAS  Google Scholar 

  • Grigsby PW et al. (2001) Long-term follow-up of RTOG 92-10: cervical cancer with positive para-aortic lymph nodes. Int J Radiat Oncol Biol Phys 51: 982–987

    Article  PubMed  CAS  Google Scholar 

  • Grigsby PW et al. (2004) Posttherapy [18F] fluorodeoxy-glucose positron emission tomography in carcinoma of the cervix: response and outcome. J Clin Oncol 22:2167–2171

    Article  PubMed  Google Scholar 

  • Hanks GE, Herring DF, Kramer S (1983) Patterns of care outcome studies. Results of the national practice in cancer of the cervix. Cancer 51:959–967

    Article  PubMed  CAS  Google Scholar 

  • Harima Y et al. (2002) Human papilloma virus (HPV) DNA associated with prognosis of cervical cancer after radiotherapy. Int J Radiat Oncol Biol Phys 52:1345–1351

    Article  PubMed  CAS  Google Scholar 

  • Hernandez-Hernandez DM et al. (2003) Association between high-risk human papillomavirus DNA load and precursor lesions of cervical cancer in Mexican women. Gynecol Oncol 90:310–317

    Article  PubMed  CAS  Google Scholar 

  • Herzog TJ (2003) New approaches for the management of cervical cancer. Gynecol Oncol 90:S22–S27

    Article  PubMed  Google Scholar 

  • Horiot JC et al. (1988) Radiotherapy alone in carcinoma of the intact uterine cervix according to G.H. Fletcher guidelines: a French cooperative study of 1383 cases. Int J Radiat Oncol Biol Phys 14:605–611

    PubMed  CAS  Google Scholar 

  • Husseinzadeh N et al. (1984) The preservation of ovarian function in young women undergoing pelvic radiation therapy. Gynecol Oncol 18:373–379

    Article  PubMed  CAS  Google Scholar 

  • ICRU (1985) Dose and volume specification for reporting intracavitary therapy in gynecology. ICRU Report 38:1

    Google Scholar 

  • Jhingran A, Eifel PJ (2000) Perioperative and postoperative complications of intracavitary radiation for FIGO stage IIII carcinoma of the cervix. Int J Radiat Oncol Biol Phys 46:1177–1183

    Article  PubMed  CAS  Google Scholar 

  • Karolewski K et al. (1999) Prognostic significance of pretherapeutic and therapeutic factors in patients with advanced cancer of the uterine cervix treated with radical radiotherapy alone. Acta Oncologica 38:461–468

    Article  PubMed  CAS  Google Scholar 

  • Katz A, Eifel PJ (2000) Quantification of intracavitary brachytherapy parameters and correlation with outcome in patients with carcinoma of the cervix (see comment). Int J Radiat Oncol Biol Phys 48:1417–1425

    Article  PubMed  CAS  Google Scholar 

  • Keys HM et al. (1999) Cisplatin, radiation, and adjuvant hysterectomy compared with radiation and adjuvant hysterectomy for bulky stage IB cervical carcinoma. N Engl J Med 340:1154–1161

    Article  PubMed  CAS  Google Scholar 

  • Kim RY et al. (1989) Radiation alone in the treatment of cancer of the uterine cervix: analysis of pelvic failure and dose response relationship. Int J Radiat Oncol Biol Phys 17:973–978

    PubMed  CAS  Google Scholar 

  • Kramer C et al. (1989) Radiation treatment of FIGO stage IVA carcinoma of the cervix. Gynecol Oncol 32:323–326

    Article  PubMed  CAS  Google Scholar 

  • Kucera H et al. (1986) Prognosis of primary radiotherapy of cervix cancer in younger females (in German). Geburtshilfe Frauenheilkd 46:800–803

    Article  PubMed  CAS  Google Scholar 

  • Kucera H et al. (1987) The influence of nicotine abuse and diabetes mellitus on the results of primary irradiation in the treatment of carcinoma of the cervix. Cancer 60:1–4

    Article  PubMed  CAS  Google Scholar 

  • Kutcher GJ et al. (1994) Comprehensive QA for radiation oncology: report of AAPM Radiation Therapy Committee Task Group 40. Med Phys 21:581–618

    Article  PubMed  CAS  Google Scholar 

  • Landoni F et al. (1997) Randomised study of radical surgery versus radiotherapy for stage Ib-IIa cervical cancer (see comment). Lancet 350:535–540

    Article  PubMed  CAS  Google Scholar 

  • Leibel S et al. (1987) Radiotherapy with or without misonidazole for patients with stage IIIB or stage IVA squamous cell carcinoma of the uterine cervix: preliminary report of a Radiation Therapy Oncology Group randomized trial. Int J Radiat Oncol Biol Phys 13:541–549

    PubMed  CAS  Google Scholar 

  • Lieu D (1996) The Papanicolaou smear: its value and limitations (see comment). J Fam Pract 42:391–399

    PubMed  CAS  Google Scholar 

  • Lukka H et al. (2002) Concurrent cisplatin-based chemotherapy plus radiotherapy for cervical cancer — a meta-analysis (see comment). Clin Oncol (Royal College of Radiologists) 14:203–212

    Article  CAS  Google Scholar 

  • Mashburn J, Scharbo-DeHaan M (1997) A clinician’s guide to Pap smear interpretation (see comment). Nurse Practitioner 22:115–118

    PubMed  CAS  Google Scholar 

  • Mendenhall WM et al. (1984) Prognostic and treatment factors affecting pelvic control of Stage IB and IIA-B carcinoma of the intact uterine cervix treated with radiation therapy alone. Cancer 53:2649–2654

    Article  PubMed  CAS  Google Scholar 

  • Montana GS, Fowler WC (1989) Carcinoma of the cervix: analysis of bladder and rectal radiation dose and complications. Int J Radiat Oncol Biol Phys 16:95–100

    PubMed  CAS  Google Scholar 

  • Montana GS et al. (1983) Carcinoma of the cervix stage IB: results of treatment with radiation therapy. Int J Radiat Oncol Biol Phys 9:45–49

    PubMed  CAS  Google Scholar 

  • Montana GS et al. (1985) Analysis of results of radiation therapy for stage II carcinoma of the cervix. Cancer 55:956–962

    Article  PubMed  CAS  Google Scholar 

  • Montana GS et al. (1986) Carcinoma of the cervix, stage III. Results of radiation therapy. Cancer 57:148–154

    Article  PubMed  CAS  Google Scholar 

  • Montana GS et al. (1987) Analysis of results of radiation therapy for stage IB carcinoma of the cervix. Cancer 60:2195–2200

    Article  PubMed  CAS  Google Scholar 

  • Montana GS, Martz KL, Hanks GE (1991) Patterns and sites of failure in cervix cancer treated in the U.S.A. in 1978. Int J Radiat Oncol Biol Phys 20:87–93

    PubMed  CAS  Google Scholar 

  • Mutic S et al. (2003) PET-guided IMRT for cervical carcinoma with positive para-aortic lymph nodes — a dose-escalation treatment planning study. Int J Radiat Oncol Biol Phys 55:28–35

    Article  PubMed  Google Scholar 

  • Nag S et al. (1999) The American brachytherapy society survey of brachytherapy practice for carcinoma of the cervix in the United States. Gynecol Oncol 73:111–118

    Article  PubMed  CAS  Google Scholar 

  • Nag S et al. (2002) The American Brachytherapy Society recommendations for low-dose-rate brachytherapy for carcinoma of the cervix (see comment). Int J Radiat Oncol Biol Phys 52:33–48 (erratum 52:1157)

    Article  PubMed  Google Scholar 

  • Orton CG (1998) High and low dose-rate brachytherapy for cervical carcinoma. Acta Oncol 37:117–125

    Article  PubMed  CAS  Google Scholar 

  • Perez CA et al. (1984) Radiation therapy alone in the treatment of carcinoma of the uterine cervix. II. Analysis of complications. Cancer 54:235–246

    Article  PubMed  CAS  Google Scholar 

  • Perez CA et al. (1998) Tumor size, irradiation dose, and long-term outcome of carcinoma of uterine cervix. Int J Radiat Oncol Biol Phys 41:307–317

    Article  PubMed  CAS  Google Scholar 

  • Perez CA et al. (1999) Radiation therapy morbidity in carcinoma of the uterine cervix: dosimetric and clinical correlation. Int J Radiat Oncol Biol Phys 44:855–866

    Article  PubMed  CAS  Google Scholar 

  • Perlman SE (1999) Pap smears: screening, interpretation, treatment. Adolescent Medicine State of the Art Reviews 10:243–254

    CAS  Google Scholar 

  • Peters WA, 3rd, et al. (2000) Concurrent chemotherapy and pelvic radiation therapy compared with pelvic radiation therapy alone as adjuvant therapy after radical surgery in high-risk early-stage cancer of the cervix. J Clin Oncol 18:1606–1613

    PubMed  CAS  Google Scholar 

  • Potish RA (1992) Cervix cancer. In: Lewitt SH (ed) Technological basis of radiation therapy. Lea & Febiger, Philadelphia, p 289

    Google Scholar 

  • Potish RA, Gerbi BJ (1986) Role of point A in the era of computerized dosimetry. Radiology 158:827–831

    PubMed  CAS  Google Scholar 

  • Potish RA, Twiggs LB (1989) An analysis of adjuvant treatment strategies for carcinoma of the cervix. Am J Clin Oncol 12:430–433

    Article  PubMed  CAS  Google Scholar 

  • Potish RA, Deibel FC Jr., Khan FM (1982) The relationship between milligram-hours and dose to point A in carcinoma of the cervix. Radiology 145:479–483

    PubMed  CAS  Google Scholar 

  • Potish RA et al. (1984) The utility and limitations of decision theory in the utilization of surgical staging and extended field radiotherapy in cervical cancer. Obstet Gynecol Surv 39:555–562

    PubMed  CAS  Google Scholar 

  • Potish RA et al. (1989) The role of surgical debulking in cancer of the uterine cervix. Int J Radiat Oncol Biol Phys 17:979–984

    PubMed  CAS  Google Scholar 

  • Pourquier H et al. (1987) A quantified approach to the analysis and prevention of urinary complications in radiotherapeutic treatment of cancer of the cervix. Int J Radiat Oncol Biol Phys 13:1025–1033

    PubMed  CAS  Google Scholar 

  • Rose PG et al. (1999) Concurrent cisplatin-based radiotherapy and chemotherapy for locally advanced cervical cancer. N Engl J Med 340:1144–1153

    Article  PubMed  CAS  Google Scholar 

  • Sasaoka M et al. (2001) Patterns of failure in carcinoma of the uterine cervix treated with definitive radiotherapy alone. Am J Clin Oncol 24:586–590

    Article  PubMed  CAS  Google Scholar 

  • Sedlis A et al. (1999) A randomized trial of pelvic radiation therapy versus no further therapy in selected patients with stage IB carcinoma of the cervix after radical hysterectomy and pelvic lymphadenectomy: A Gynecologic Oncology Group Study (see comment). Gynecol Oncol 73:177–183

    Article  PubMed  CAS  Google Scholar 

  • Singh AK et al. (2003) FDG-PET lymph node staging and survival of patients with FIGO stage IIIb cervical carcinoma. Int J Radiat Oncol Biol Phys 56:489–493

    Article  PubMed  Google Scholar 

  • Sommers GM et al. (1989) Outcome of recurrent cervical carcinoma following definitive irradiation. Gynecol Oncol 35:150–155

    Article  PubMed  CAS  Google Scholar 

  • Thoms WW Jr., et al. (1992) Bulky endocervical carcinoma: a 23-year experience. Int J Radiat Oncol Biol Phys 23:491–499

    PubMed  Google Scholar 

  • Tsai CS et al. (2004) Preliminary report of using FDG-PET to detect extrapelvic lesions in cervical cancer patients with enlarged pelvic lymph nodes on MRI/CT. Int J Radiat Oncol Biol Phys 58:1506–1512

    Article  PubMed  Google Scholar 

  • Unal A et al. (1981) An analysis of the severe complications of irradiation of carcinoma of the uterine cervix: treatment with intracavitary radium and parametrial irradiation. Int J Radiat Oncol Biol Phys 7:999–1004

    PubMed  CAS  Google Scholar 

  • Waggoner SE (2003) Cervical cancer. Lancet 361:2217–2225

    Article  PubMed  Google Scholar 

  • Whitney CW et al. (1999) Randomized comparison of fluorouracil plus cisplatin versus hydroxyurea as an adjunct to radiation therapy in stage IIB-IVA carcinoma of the cervix with negative para-aortic lymph nodes: a gynecologic Oncology Group and Southwest Oncology Group study. J Clin Oncol 17:1339–1348

    PubMed  CAS  Google Scholar 

  • Willen H et al. (1985) Invasive squamous cell carcinoma of the uterine cervix. VIII. Survival and malignancy grading in patients treated by irradiation in Lund 1969–1970. Acta Radiol Oncol 24:41–50

    PubMed  CAS  Google Scholar 

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Dusenbery, K.E., Gerbi, B.J. (2006). Radiation Therapy for Cervical Cancer. In: Levitt, S.H., Purdy, J.A. (eds) Technical Basis of Radiation Therapy. Medical Radiology. Springer, Berlin, Heidelberg . https://doi.org/10.1007/3-540-35665-7_24

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