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Cancers of the Colon, Rectum, and Anus

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Technical Basis of Radiation Therapy

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References

  • Bartelink H, Roelofsen F, Eschwege F et al (1997) Concomitant radiotherapy and chemotherapy is superior to radiotherapy alone in the treatment of locally advanced anal cancer: results of a phase III randomized trial of the European Organization for Research and Treatment of Cancer Radiotherapy and Gastrointestinal Cooperative Groups. J Clin Oncol 15:2040–2049

    PubMed  CAS  Google Scholar 

  • Beart RW Jr, O’Connell MJ (1983) Postoperative follow-up of patients with carcinoma of the colon. Mayo Clin Proc 58:361–363

    PubMed  Google Scholar 

  • Benson AB III, Desch CE, Flynn PJ et al (2000) 2000 Update of American Society of Clinical Oncology colorectal cancer surveillance guidelines. J Clin Oncol 18:3586–3588

    PubMed  Google Scholar 

  • Black WA, Waugh JM (1948) Intramural extension of carcinoma of descending colon, sigmoid, and rectosigmoid: pathologic study. Surg Gynecol Obstet 84:457–464

    Google Scholar 

  • Boman BM, Moertel CG, O’Connell MJ et al (1984) Carcinoma of the anal canal: a clinical and pathologic study of 188 cases. Cancer 54:114–125

    Article  PubMed  CAS  Google Scholar 

  • Cass AW, Million RR, Pfaff WW (1976) Patterns of recurrence following surgery alone for adenocarcinoma of the colon and rectum. Cancer 37:2861–2865

    Article  PubMed  CAS  Google Scholar 

  • Chary S, Thomson DH (1984) A clinical trial evaluating cholestyramine to prevent diarrhea in patients maintained on low-fat diets during pelvic radiotherapy. Int J Radiat Oncol Biol Phys 10:1885–1890

    PubMed  CAS  Google Scholar 

  • Cohen AM, Gunderson LL, Welch CE (1981) Selective use of adjuvant radiotherapy in resectable colorectal adenocarcinoma. Dis Colon Rectum 24:247–251

    PubMed  CAS  Google Scholar 

  • Dahlberg M, Glimelius B, Graft W et al (1998) Preoperative irradiation affects functional results after surgery for rectal cancer: results from a randomized study. Dis Colon Rectum 41:543–549

    Article  PubMed  CAS  Google Scholar 

  • Douglass HO Jr, Moertel CG, Mayer RJ et al (1986) Survival after postoperative combination treatment of rectal cancer (letter). N Engl J Med 315:1294–1295

    Article  PubMed  Google Scholar 

  • Enquist IF, Block IR (1966) Rectal cancer in the female: selection of proper operation based upon anatomic studies of rectal lymphatics. Prog Clin Cancer 2:73–85

    Google Scholar 

  • Flam M, John M, Pajak TF et al (1996) Role of mitomycin in combination with fluorouracil and radiotherapy, and of salvage chemoradiation in the definitive nonsurgical treatment of epidermoid carcinoma of the anal canal: results of a phase III randomized intergroup study. J Clin Oncol 14:2527–2539

    PubMed  CAS  Google Scholar 

  • Fletcher RH (1986) Carcinoembryonic antigen. Ann Intern Med 104:66–73

    PubMed  CAS  Google Scholar 

  • Fletcher RH (1993) CEA monitoring after surgery for colorectal cancer. When is the evidence sufficient? (Editorial.) JAMA 270:987–988

    Article  PubMed  CAS  Google Scholar 

  • Gallagher MJ, Brereton HD, Rostock RA et al (1986) A prospective study of treatment techniques to minimize the volume of pelvic small bowel with reduction of acute and late effects associated with pelvic irradiation. Int J Radiat Oncol Biol Phys 12:1565–1573

    PubMed  CAS  Google Scholar 

  • Gastrointestinal Tumor Study Group (1985) Prolongation of the disease-free interval in surgically treated rectal carcinoma. N Engl J Med 312:1465–1472

    Article  Google Scholar 

  • Gilbert SG (1978) Symptomatic local tumor failure following abdomino-perineal resection. Int J Radiat Oncol Biol Phys 4:801–807

    PubMed  CAS  Google Scholar 

  • Gilbertsen VA (1960) Adenocarcinoma of the rectum: incidence and locations of recurrent tumor following presentday operations performed for cure. Ann Surg 151:340–348

    CAS  PubMed  Google Scholar 

  • Green N (1983) The avoidance of small intestine injury in gynecologic cancer. Int J Radiat Oncol Biol Phys 9:1385–1390

    PubMed  CAS  Google Scholar 

  • Green N, Iba G, Smith WR (1975) Measures to minimize small intestine injury in the irradiated pelvis. Cancer 35:1633–1640

    Article  PubMed  CAS  Google Scholar 

  • Grinnell RS (1966) Lymphatic block with atypical and retrograde lymphatic metastasis and spread in carcinoma of the colon and rectum. Ann Surg 163:272–280

    PubMed  CAS  Google Scholar 

  • Gunderson LL, Sosin H (1974) Areas of failure found at reoperation (second or symptomatic look) following “curative surgery” for adenocarcinoma of the rectum: clinicopathologic correlation and implications for adjuvant therapy. Cancer 34:1278–1292

    Article  PubMed  CAS  Google Scholar 

  • Gunderson LL, Cohen AM, Welch CE (1980) Residual, inoperable or recurrent colorectal cancer: interaction of surgery and radiotherapy. Am J Surg 139:518–525

    Article  PubMed  CAS  Google Scholar 

  • Gunderson LL, Cohen AC, Dosoretz DD et al (1983a) Residual, unresectable, or recurrent colorectal cancer: external beam irradiation and intraoperative electron beam boost +/− resection. Int J Radiat Oncol Biol Phys 9:1597–1606

    PubMed  CAS  Google Scholar 

  • Gunderson LL, Meyer JE, Sheedy PF et al (1983b) Radiation oncology. In: Margulis AR, Burhenne HJ (eds) Alimentary tract radiology, vol 2, 3rd edn. CV Mosby, St Louis, pp 2409–2446

    Google Scholar 

  • Gunderson LL, Tepper JE, Dosoretz DE et al (1983c) Patterns of failure after treatment of gastrointestinal cancer. Cancer Treat Symp 2:181–197

    Google Scholar 

  • Gunderson LL, Russell AH, Llewellyn HJ et al (1985a) Treatment planning for colorectal cancer: radiation and surgical techniques and value of small-bowel films. Int J Radiat Oncol Biol Phys 11:1379–1393

    PubMed  CAS  Google Scholar 

  • Gunderson LL, Sosin H, Levitt S (1985b) Extrapelvic colon: areas of failure in a reoperation series; implications for adjuvant therapy. Int J Radiat Oncol Biol Phys 11:731–741

    PubMed  CAS  Google Scholar 

  • Gunderson LL, Collins R, Earle JD, et al (1986) Adjuvant treatment of rectal cancer: randomized prospective study of irradiation +/− chemotherapy: a NCCTG, Mayo Clinic study (abstract). Int J Radiat Oncol Biol Phys 12[Suppl 1]:169

    Google Scholar 

  • Gunderson LL, Martenson JA, Haddock MG (1996a) Indications for and results of irradiation +/− chemotherapy for rectal cancer. Ann Acad Med Singapore 25:448–459

    PubMed  CAS  Google Scholar 

  • Gunderson LL, Nelson H, Martenson JA et al (1996b) Intraoperative electron and external beam irradiation with or without 5-fluorouracil and maximum surgical resection for previously unirradiated, locally recurrent colorectal cancer. Dis Colon Rectum 39:1379–1395

    Article  PubMed  CAS  Google Scholar 

  • Gunderson LL, Sargent DJ, Tepper JE et al (2004) Impact of T and N stage and treatment on survival and relapse in adjuvant rectal cancer: a pooled analysis. J Clin Oncol 22:1785–1796

    Article  PubMed  Google Scholar 

  • Haddock MG, Gunderson LL, Nelson H et al (2001) Intraoperative irradiation for locally recurrent colorectal cancer in previously irradiated patients. Int J Radiat Oncol Biol Phys 49:1267–1274

    Article  PubMed  CAS  Google Scholar 

  • Haddock MG, Nelson H, Donohue JH et al (2003) Intraoperative electron radiotherapy as a component of salvage therapy for patients with colorectal cancer and advanced nodal metastases. Int J Radiat Oncol Biol Phys 56:966–973

    Article  PubMed  Google Scholar 

  • Henriksson R, Franzen L, Littbrand B (1992) Effects of sucralfate on acute and late bowel discomfort following radiotherapy of pelvic cancer. J Clin Oncol 10:969–975

    PubMed  CAS  Google Scholar 

  • Hoskins RB, Gunderson LL, Dosoretz DE et al (1985) Adjuvant postoperative radiotherapy in carcinoma of the rectum and rectosigmoid. Cancer 55:61–71

    Article  PubMed  CAS  Google Scholar 

  • John MJ, Pajak TJ, Flam MS et al (1995) Dose acceleration in chemoradiation (CRX) for anal cancer: preliminary results of RTOG 92’08 (abstract). Int J Radiat Oncol Biol Phys 32[Suppl 1]:157

    Article  Google Scholar 

  • Kollmorgen CF, Meagher AP, Wolff BG et al (1994) The longterm effect of adjuvant postoperative chemoradiotherapy for rectal carcinoma on bowel function. Ann Surg 220:676–682

    PubMed  CAS  Google Scholar 

  • Krook JE, Moertel CG, Gunderson LL et al (1991) Effective surgical adjuvant therapy for high-risk rectal carcinoma. N Engl J Med 324:709–715

    Article  PubMed  CAS  Google Scholar 

  • Lindel K, Willett CG, Shellito PC et al (2001) Intraoperative radiotherapy for locally advanced recurrent rectal or rectosigmoid cancer. Radiother Oncol 58:83–87

    Article  PubMed  CAS  Google Scholar 

  • Lundby L, Jensen VJ, Overgaard J et al (1997) Long-term colorectal function after postoperative radiotherapy for colorectal cancer. Lancet 350:564

    Article  PubMed  CAS  Google Scholar 

  • Mannaerts GH, Martijn H, Crommelin MA et al (1999) Intraoperative electron beam radiotherapy for locally recurrent rectal carcinoma. Int J Radiat Oncol Biol Phys 45:297–308

    Article  PubMed  CAS  Google Scholar 

  • Mannaerts GH, Rutten HJ, Martijn H et al (2002) Effects on functional outcome after IORT-containing multimodality treatment for locally advanced primary and locally recurrent rectal cancer. Int J Radiat Oncol Biol Phys 54:1082–1088

    Article  PubMed  Google Scholar 

  • Martenson JA Jr, Gunderson LL (1993) External radiotherapy without chemotherapy in the management of anal cancer. Cancer 71:1736–1740

    Article  PubMed  Google Scholar 

  • Martenson JA Jr, Hyland G, Moertel CG et al (1996a) Olsalazine is contraindicated during pelvic radiotherapy: results of a double-blind, randomized clinical trial. Int J Radiat Oncol Biol Phys 35:299–303

    Article  PubMed  CAS  Google Scholar 

  • Martenson JA, Lipsitz SR, Wagner H Jr et al (1996b) Initial results of a phase II trial of high dose radiotherapy, 5-fluorouracil, and cisplatin for patients with anal cancer (E4292): an Eastern Cooperative Oncology Group Study. Int J Radiat Oncol Biol Phys 35:745–749

    Article  PubMed  CAS  Google Scholar 

  • Martenson JA, Schild SE, Haddock MG (1998) Cancers of the gastrointestinal tract. In: Khan FM, Potish RA (eds) Treatment planning in radiation oncology. Williams and Wilkins, Baltimore, pp 319–342

    Google Scholar 

  • Martenson JA, Bollinger JW, Sloan JA et al (2000) Sucralfate in the prevention of treatment-induced diarrhea in patients receiving pelvic radiotherapy: a North Central Cancer Treatment Group phase III double-blind placebo-controlled trial. J Clin Oncol 18:1239–1245

    PubMed  CAS  Google Scholar 

  • Martin EW Jr, James KK, Hurtubise PE et al (1977) The use of CEA as an early indicator for gastrointestinal tumor recurrence and second-look procedures. Cancer 39:440–446

    Article  PubMed  Google Scholar 

  • Mendenhall WM, Million RR, Pfaff WW (1983) Patterns of recurrence in adenocarcinoma of the rectum and rectosigmoid treated with surgery alone: implications in treatment planning with adjuvant radiotherapy. Int J Radiat Oncol Biol Phys 9:977–985

    PubMed  CAS  Google Scholar 

  • Minsky BD, Mies C, Rich TA et al (1988) Potentially curative surgery of colon cancer: patterns of failure and survival. J Clin Oncol 6:106–118

    PubMed  CAS  Google Scholar 

  • Minton JP, Hoehn JL, Gerber DM et al (1985) Results of a 400-patient carcinoembryonic antigen second-look colorectal cancer study. Cancer 55:1284–1290

    Article  PubMed  CAS  Google Scholar 

  • Moertel CG, Schutt AJ, Go VL (1978) Carcinoembryonic antigen test for recurrent colorectal carcinoma: inadequacy for early detection. JAMA 239:1065–1066

    Article  PubMed  CAS  Google Scholar 

  • Moertel CG, Fleming TR, Macdonald JS et al (1993) An evaluation of the carcinoembryonic antigen (CEA) test for monitoring patients with resected colon cancer. JAMA 270:943–947

    Article  PubMed  CAS  Google Scholar 

  • Morson BC (1960) The pathology and results of treatment of squamous cell carcinoma of the anal canal and anal margin. Proc R Soc Med 53:416–420

    Google Scholar 

  • Nivatvongs S, Stern HS, Fryd DS (1981) The length of the anal canal. Dis Colon Rectum 24:600–601

    PubMed  CAS  Google Scholar 

  • Northover J, Houghton J, Lennon T (1994) CEA to detect recurrence of colon cancer (letter). JAMA 272:31

    Article  PubMed  CAS  Google Scholar 

  • Noyes RD, Weiss SM, Krall JM et al (1992) Surgical complications of intraoperative radiotherapy: the Radiotherapy Oncology Group experience. J Surg Oncol 50:209–215

    PubMed  CAS  Google Scholar 

  • O’Connell MJ, Martenson JA, Wieand HS et al (1994) Improving adjuvant therapy for rectal cancer by combining protracted-infusion fluorouracil with radiotherapy after curative surgery. N Engl J Med 331:502–507

    Article  PubMed  CAS  Google Scholar 

  • Patterson DJ, Alpert E (1983) Tumour markers of the gastrointestinal tract. In: Hodgson HJF, Bloom SR (eds) Gastrointestinal and hepatobiliary cancer. Chapman and Hall, London, pp 189–205

    Google Scholar 

  • Postlethwait RW (1949) Malignant tumors of the colon and rectum. Ann Surg 129:34–46

    CAS  PubMed  Google Scholar 

  • Rich T, Gunderson LL, Lew R et al (1983) Patterns of recurrence of rectal cancer after potentially curative surgery. Cancer 52:1317–1329

    Article  PubMed  CAS  Google Scholar 

  • Romsdahl MM, Withers HR (1978) Radiotherapy combined with curative surgery: its use as therapy for carcinoma of the sigmoid colon and rectum. Arch Surg 113:446–453

    PubMed  CAS  Google Scholar 

  • Russell AH, Tong D, Dawson LE et al (1984) Adenocarcinoma of the proximal colon: sites of initial dissemination and patterns of recurrence following surgery alone. Cancer 53:360–367

    Article  PubMed  CAS  Google Scholar 

  • Sauer R (2003) Adjuvant versus neoadjuvant combined modality treatment for locally advanced rectal cancer: first results of the German Rectal Cancer Study (CAO/ARO/AIO-94) (abstract). Int J Radiat Oncol Biol Phys 57[Suppl]:S124–S125

    Article  Google Scholar 

  • Schild SE, Martenson JA Jr, Gunderson LL et al (1989) Postoperative adjuvant therapy of rectal cancer: an analysis of disease control, suvival, and prognostic factors. Int J Radiat Oncol Biol Phys 17:55–62

    PubMed  CAS  Google Scholar 

  • Schild SE, Gunderson LL, Haddock MG et al (1997) The treatment of locally advanced colon cancer. Int J Radiat Oncol Biol Phys 37:51–58

    Article  PubMed  CAS  Google Scholar 

  • Shanahan TG, Mehta MP, Gehring MA et al (1989) Minimization of small bowel volume utilizing customized “belly board” mold (abstract). Int J Radiat Oncol Biol Phys 17[Suppl 1]:187–188

    Google Scholar 

  • Shaw EG, Gunderson LL, Martin JK et al (1990) Peripheral nerve and ureteral tolerance to intraoperative radiation therapy: clinical and dose-reponse analysis. Radiother Oncol 18:247–255

    Article  PubMed  CAS  Google Scholar 

  • Stearns MW Jr, Urmacher C, Sternberg SS et al (1980) Cancer of the anal canal. Curr Probl Cancer 4:1–44

    PubMed  Google Scholar 

  • Suzuki K, Gunderson LL, Devine RM et al (1995) Intraoperative irradiation after palliative surgery for locally recurrent rectal cancer. Cancer 75:939–952

    Article  PubMed  CAS  Google Scholar 

  • Swedish Rectal Cancer Trial (1997) Improved survival with preoperative radiotherapy in resectable rectal cancer. N Engl J Med 336:980–987. Erratum in: N Engl J Med 1997, 336:1539

    Article  Google Scholar 

  • Taylor N, Crane C, Skibber J et al (2001) Elective groin irradiation is not indicated for patients with adenocarcinoma of the rectum extending to the anal canal. Int J Radiat Oncol Biol Phys 51:741–747

    Article  PubMed  CAS  Google Scholar 

  • Tepper JE, Gunderson LL, Orlow E et al (1984) Complications of intraoperative radiotherapy. Int J Radiat Oncol Biol Phys 10:1831–1839

    PubMed  CAS  Google Scholar 

  • Tveit KM, Guldvog I, Hagen S, et al (1997) Randomized controlled trial of postoperative radiotherapy and short-term time-scheduled 5-fluorouracil against surgery alone in the treatment of Dukes B and C rectal cancer. Br J Surg 84:1130–1135

    Article  PubMed  CAS  Google Scholar 

  • UKCCCR Anal Cancer Trial Working Party (1996) Epidermoid anal cancer: results from the UKCCCR randomised trial of radiotherapy alone versus radiotherapy, 5-fluorouracil, and mitomycin. Lancet 348:1049–1054

    Article  Google Scholar 

  • Walz BJ, Green MR, Lindstrom ER et al (1981) Anatomical prognostic factors after abdominal perineal resection. Int J Radiat Oncol Biol Phys 7:477–484

    PubMed  CAS  Google Scholar 

  • Wanebo HJ, Rao B, Pinsky CM et al (1978) Preoperative carcinoembryonic antigen level as a prognostic indicator in colorectal cancer. N Engl J Med 299:448–451

    Article  PubMed  CAS  Google Scholar 

  • Welch JP, Donaldson GA (1978) Detection and treatment of recurrent cancer of the colon and rectum. Am J Surg 135:505–511

    Article  PubMed  CAS  Google Scholar 

  • Welch JP, Donaldson GA (1979) The clinical correlation of an autopsy study of recurrent colorectal cancer. Ann Surg 189:496–502

    PubMed  CAS  Google Scholar 

  • Wiig JN, Tveit KM, Poulsen JP et al (2002) Preoperative irradiation and surgery for recurrent rectal cancer: will intraoperative radiotherapy (IORT) be of additional benefit? A prospective study. Radiother Oncol 62:207–213

    Article  PubMed  Google Scholar 

  • Willett C, Tepper JE, Cohen A et al (1984a) Local failure following curative resection of colonic adenocarcinoma. Int J Radiat Oncol Biol Phys 10:645–651

    PubMed  CAS  Google Scholar 

  • Willett CG, Tepper JE, Cohen AM et al (1984b) Failure patterns following curative resection of colonic carcinoma. Ann Surg 200:685–690

    PubMed  CAS  Google Scholar 

  • Withers HR, Cuasay L, Mason KA et al (1981) Elective radiotherapy in the curative treatment of cancer of the rectum and retrosigmoid colon. In: Stroehlein JR, Romsdahl MM (eds) Gastrointestinal cancer. Raven, New York, pp 351–362

    Google Scholar 

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Martenson, J.A., Haddock, M.G., Gunderson, L.L. (2006). Cancers of the Colon, Rectum, and Anus. In: Levitt, S.H., Purdy, J.A. (eds) Technical Basis of Radiation Therapy. Medical Radiology. Springer, Berlin, Heidelberg . https://doi.org/10.1007/3-540-35665-7_22

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