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A New Model Describes an Aqueous Outflow Pump and Explores Causes of Pump Failure in Glaucoma

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Glaucoma

Part of the book series: Essentials in Ophthalmology ((ESSENTIALS))

1.10 Conclusion

This chapter provides a summary of evidence that supports the presence of a pumping mechanism that returns aqueous to the vascular system. The aqueous pumping mechanism controls normal flow and pressure. The pumping mechanism fails in glaucoma. Clinical and laboratory evidence point to reduced trabecular movement and persistent SC closure as mechanisms causing pump failure. An intrinsic abnormality of the composition of trabecular tissues may alter normal distention and recoil. Extrinsic factors that may also lead to SC closure are altered shape of the limbal region, altered flexibility of the limbus at the corneoscleral junction, and alterations in ciliary body tension.

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Author information

Authors and Affiliations

  1. Department of Ophthalmology, Swedish Medical Center, 1221 Madison #1124, Seattle, WA, 98104, USA

    Murray A. Johnstone MD

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  1. Murray A. Johnstone MD
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Editors and Affiliations

  1. Department of Ophthalmology, University of Wuerzburg, Josef-Schneider-Straße 11, 97080, Wuerzburg, Germany

    Franz Grehn MD (Professor and Chairman) (Professor and Chairman)

  2. Department of Ophthalmology, USCF, 10 Kirkham Street, Rm K301, San Francisco, CA, 94143, USA

    Robert Stamper MD (Director of Glaucoma Service) (Director of Glaucoma Service)

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© 2006 Springer-Verlag Berlin Heidelberg

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Johnstone, M.A. (2006). A New Model Describes an Aqueous Outflow Pump and Explores Causes of Pump Failure in Glaucoma. In: Grehn, F., Stamper, R. (eds) Glaucoma. Essentials in Ophthalmology. Springer, Berlin, Heidelberg . https://doi.org/10.1007/3-540-34773-9_1

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  • DOI: https://doi.org/10.1007/3-540-34773-9_1

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-540-26220-6

  • Online ISBN: 978-3-540-34773-6

  • eBook Packages: MedicineMedicine (R0)

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