Abstract
Polyphosphate (poly P) granules were one of the first subcellular structures described in bacteria and are characterized by their high content of phosphorus in the form of poly P. Recent work has shown that poly P granules have a limiting membrane and possess an enzymatic mechanism for their acidification. Their electron density and enrichment in pyrophosphate (PPi), poly P, and cations such as calcium and magnesium are characteristics in common with those of the organelles described as acidocalcisomes in a number of eukaryotic cells, including human platelets, indicating that they have been conserved during evolution from prokaryotes to eukaryotes. Acidocalcisomes have multiple functions that are related to the functions of their main constituents, PPi, poly P, and cations.
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Docampo, R. (2006). Acidocalcisomes and Polyphosphate Granules. In: Shively, J.M. (eds) Inclusions in Prokaryotes. Microbiology Monographs, vol 1. Springer, Berlin, Heidelberg. https://doi.org/10.1007/3-540-33774-1_3
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