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Quantitative Surface-Enhanced Resonance Raman Spectroscopy for Analysis

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Surface-Enhanced Raman Scattering

Part of the book series: Topics in Applied Physics ((TAP,volume 103))

5 Summary

In this Chapter, we adhere to a basic philosophy for obtaining quantitative SERRS. Effective quantitative SERRS is best obtained where the analyte is preselected either by choosing a suitable molecule such as mitoxantrone that has an intrinsic SERRS activity or by the use of labeling/derivatization chemistry. For the best results, the molecule should adhere strongly to the SERRS surface and have a chromophore close to the excitation frequency. Quantitation is easily obtained by averaging a number of events such as those that will occur if a suspension of colloid is used. The advantages in sensitivity and selectivity of SERRS detection make it very attractive for the next generation of bioanalytical equipment and for the solution to problems where extreme sensitivity is required.

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Authors and Affiliations

  1. Centre for Molecular Nanometrology, WestCHEM, Department of Pure and Applied Chemistry, University of Strathclyde, 295 Cathedral Street, Glasgow, G1 1XL, Scotland

    W. E. Smith, K. Faulds & D. Graham

Authors
  1. W. E. Smith
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  2. K. Faulds
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  3. D. Graham
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Editor information

Editors and Affiliations

  1. Wellman Center for Photomedicine Harvard-M.I.T. Division of Health Sciences & Technology, Harvard University, Medical School, Boston, MA, 02114, USA

    Katrin Kneipp

  2. Department of Chemistry and Biochemistry, University of California Santa Barbara, Santa Barbara, CA, 93105, USA

    Martin Moskovits

  3. Wellman Center for Photomedicine, Harvard University, Medical School, Boston, MA, 02114, USA

    Harald Kneipp

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© 2006 Springer-Verlag Berlin Heidelberg

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Smith, W.E., Faulds, K., Graham, D. (2006). Quantitative Surface-Enhanced Resonance Raman Spectroscopy for Analysis. In: Kneipp, K., Moskovits, M., Kneipp, H. (eds) Surface-Enhanced Raman Scattering. Topics in Applied Physics, vol 103. Springer, Berlin, Heidelberg . https://doi.org/10.1007/3-540-33567-6_20

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