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Aspiration-induced Lung Injury: Experimental and Human Studies

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Yearbook of Intensive Care and Emergency Medicine

Part of the book series: Yearbook of Intensive Care and Emergency Medicine ((YEARBOOK,volume 2006))

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References

  1. Eisner MD, Thompson T, Hudson LD, et al (2001) Efficacy of low tidal volume ventilation in patients with different clinical risk factors for acute lung injury and the acute respiratory distress syndrome. Am J Respir Crit Care Med 64:231–236

    Google Scholar 

  2. Ware LB, Matthay MA (2000) The acute respiratory distress syndrome. N Engl J Med 342:1334–1349

    Article  CAS  PubMed  Google Scholar 

  3. Adnet F, Baud F (1996) Relation between Glasgow Coma Scale and aspiration pneumonia. Lancet 348:123–124

    Article  CAS  PubMed  Google Scholar 

  4. Rebuck JA, Rasmussen JR, Olsen KM (2001) Clinical aspiration-related practice patterns in the intensive care unit: a physician survey. Crit Care Med 29:2239–2244

    Article  CAS  PubMed  Google Scholar 

  5. Folkesson HG, Matthay MA, Hebert CA, Broaddus VC (1995) Acid aspiration-induced lung injury in rabbits is mediated by interleukin-8-dependent mechanisms. J Clin Invest 96:107–116

    Article  CAS  PubMed  Google Scholar 

  6. van Westerloo DJ, Knapp S, van’t Veer C, et al (2005) Aspiration pneumonitis primes the host for an exaggerated inflammatory response during pneumonia. Crit Care Med 33:1770–1778

    Article  PubMed  Google Scholar 

  7. Matthay MA, Rosen GD (1996) Acid aspiration induced lung injury. New insights and therapeutic options. Am J Respir Crit Care Med 154:277–278

    CAS  PubMed  Google Scholar 

  8. Miller EJ, Cohen AB, Matthay MA (1996) Increased interleukin-8 concentrations in the pulmonary edema fluid of patients with acute respiratory distress syndrome from sepsis. Crit Care Med 24:1448–1455

    Article  CAS  PubMed  Google Scholar 

  9. Pugin J, Verghese G, Widmer MC, Matthay MA (1999) The alveolar space is the site of intense inflammatory and profibrotic reactions in the early phase of acute respiratory distress syndrome. Crit Care Med 27:304–312

    Article  CAS  PubMed  Google Scholar 

  10. Donnelly SC, Strieter RM, Kunkel SL, et al (1993) Interleukin-8 and development of adult respiratory distress syndrome in at-risk patient groups. Lancet 341:643–647

    Article  CAS  PubMed  Google Scholar 

  11. Parsons PE, Eisner MD, Thompson BT, et al (2005) Lower tidal volume ventilation and plasma cytokine markers of inflammation in patients with acute lung injury. Crit Care Med 33:1–6

    Article  CAS  PubMed  Google Scholar 

  12. Modelska K, Pittet JF, Folkesson HG, Courtney Broaddus V, Matthay MA (1999) Acid-induced lung injury. Protective effect of anti-interleukin-8 pretreatment on alveolar epithelial barrier function in rabbits. Am J Respir Crit Care Med 160:1450–1456

    CAS  PubMed  Google Scholar 

  13. Goldman G, Welbourn R, Klausner JM, et al (1991) Neutrophil accumulations due to pulmonary thromboxane synthesis mediate acid aspiration injury. J Appl Physiol 70:1511–1517

    CAS  PubMed  Google Scholar 

  14. Folkesson HG, Matthay MA (1997) Inhibition of CD18 OR CD11b attenuates acute lung injury after acid instillation in rabbits. J Appl Physiol 82:1743–1750

    Article  CAS  PubMed  Google Scholar 

  15. Doerschuk CM (2001) Mechanisms of leukocyte sequestration in inflamed lungs. MicroCirculation 8:71–88

    CAS  PubMed  Google Scholar 

  16. Nagase T, Ohga E, Sudo E, et al (1996) Intercellular adhesion molecule-1 mediates acid aspiration-induced lung injury. Am J Respir Crit Care Med 154:504–510

    CAS  PubMed  Google Scholar 

  17. Safdar Z, Yiming M, Grunig G, Bhattacharya J (2005) Inhibition of acid-induced lung injury by hyperosmolar sucrose. Am J Respir Crit Care Med 172:1002–1007

    Article  PubMed  Google Scholar 

  18. Ware LB, Matthay MA (2002) Keratinocyte and hepatocyte growth factors in the lung: roles in lung development, inflammation, and repair. Am J Physiol Lung Cell Mol Physiol 282:L924–940

    CAS  PubMed  Google Scholar 

  19. Frank JA, Gutierrez JA, Jones KD, Allen L, Dobbs L, Matthay MA (2002) Low tidal volume reduces epithelial and endothelial injury in acid-injured rat lungs. Am J Respir Crit Care Med 165:242–249

    PubMed  Google Scholar 

  20. Matthay MA, Ware LB (2004) Can nicotine treat sepsis? Nat Med 10:1161–1162

    Article  CAS  PubMed  Google Scholar 

  21. Su X, Mednick G, Matthay ZA, Uchida T, Matthay MA (2006) Nicotine reduces acid induced lung injury in ice and rats. Expt Biol (abst, in press)

    Google Scholar 

  22. Uchida T, Shirawas M, Ware LB, Hata Y, Machita K, Matthay MA (2006) RAGE is a marker of alveolar epithelial type I cell injury in acute lung injury. Am J Respir Crit Care Med (abst, in press)

    Google Scholar 

  23. McAuley DF, Frank JA, Fang X, Matthay MA (2004) Clinically relevant concentrations of beta2-adrenergic agonists stimulate maximal cyclic adenosine monophosphate-dependent airspace fluid clearance and decrease pulmonary edema in experimental acid-induced lung injury. Crit Care Med 32:1470–1476

    Article  CAS  PubMed  Google Scholar 

  24. The Acute Respiratory Distress Syndrome Network (2001) Efficacy of low tidal volume ventilation in patients with different clinical risk factors for acute lung injury and the acute respiratory distress syndrome. Am J Respir Crit Care Med 64:231–236

    Google Scholar 

  25. Frank JA, Matthay MA (2003) Science review: mechanisms of ventilator-induced injury. Crit Care 7:233–241

    Article  PubMed  Google Scholar 

  26. Atabai K, Ware LB, Snider ME, et al (2002) Aerosolized β 2-adrenergic agonists achieve therapeutic levels in the pulmonary edema fluid of ventilated patients with acute respiratory failure. Intensive Care Med 28:705–711

    Article  PubMed  Google Scholar 

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Author information

Authors and Affiliations

  1. Department of Intensive Care Medicine, Moffitt Hospital, Room M-917, 505 Parnassus Avenue, San Francisco, CA, 94143-0624, USA

    M. A. Matthay, G. Mednick & Z. A. Matthay

Authors
  1. M. A. Matthay
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  2. G. Mednick
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  3. Z. A. Matthay
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Editor information

Editors and Affiliations

  1. Department of Intensive Care, Erasme Hospital, Free University of Brussels, Route de Lennik 808, B-1070, Brussels, Belgium

    Jean-Louis Vincent (Head) (Head)

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© 2006 Springer-Verlag Berlin Heidelberg

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Matthay, M.A., Mednick, G., Matthay, Z.A. (2006). Aspiration-induced Lung Injury: Experimental and Human Studies. In: Vincent, JL. (eds) Yearbook of Intensive Care and Emergency Medicine. Yearbook of Intensive Care and Emergency Medicine, vol 2006. Springer, Berlin, Heidelberg. https://doi.org/10.1007/3-540-33396-7_33

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  • DOI: https://doi.org/10.1007/3-540-33396-7_33

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-540-30155-4

  • Online ISBN: 978-3-540-33396-8

  • eBook Packages: MedicineMedicine (R0)

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