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Hyaluronan in Acute Lung Injury

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Yearbook of Intensive Care and Emergency Medicine

Part of the book series: Yearbook of Intensive Care and Emergency Medicine ((YEARBOOK,volume 2006))

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Conclusion

Hyaluronan in HMW forms serves as an organizer of the extracellular matrix of the lung, but LMW forms act as signaling molecules that are involved in the production of inflammatory cytokines. LMW hyaluronan is produced either by breakdown of HMW hyaluronan or by de novo synthesis by HAS3. LMW hyaluronan regulates cytokine production through binding to cell surface receptors, CD44, RHAMM and TLRs. We have shown that in VILI, a form of ALI, LMW hyaluronan is produced through upregulation of HAS3 and plays an important role in production of chemokines and neutrophil infiltration found in VILI. LMW hyaluronan-induced IL-8 production in lung cells is dependent on NF-κB and JNK/AP-1 activation. Our clinical studies of LMW hyaluronan in patients at risk of ALI and patients with ALI/ARDS suggest that LMW hyaluronan may play an important role in the pathogenesis of ALI/ARDS and may offer targets for new treatment modalities.

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Authors and Affiliations

  1. Pulmonary and Critical Care Unit, Massachusetts General Hospital, Bulfinch 148, Boston, MA, 02114, USA

    D. A. Quinn & H. G. Garg

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  1. D. A. Quinn
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  2. H. G. Garg
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Editor information

Editors and Affiliations

  1. Department of Intensive Care, Erasme Hospital, Free University of Brussels, Route de Lennik 808, B-1070, Brussels, Belgium

    Jean-Louis Vincent (Head) (Head)

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© 2006 Springer-Verlag Berlin Heidelberg

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Quinn, D.A., Garg, H.G. (2006). Hyaluronan in Acute Lung Injury. In: Vincent, JL. (eds) Yearbook of Intensive Care and Emergency Medicine. Yearbook of Intensive Care and Emergency Medicine, vol 2006. Springer, Berlin, Heidelberg. https://doi.org/10.1007/3-540-33396-7_32

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  • DOI: https://doi.org/10.1007/3-540-33396-7_32

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-540-30155-4

  • Online ISBN: 978-3-540-33396-8

  • eBook Packages: MedicineMedicine (R0)

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