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Myc/Max/Mad in Invertebrates: The Evolution of the Max Network

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The Myc/Max/Mad Transcription Factor Network

Part of the book series: Current Topics in Microbiology and Immunology ((CT MICROBIOLOGY,volume 302))

Abstract

The Myc proto-oncogenes, their binding partner Max and their antagonists from the Mad family of transcriptional repressors have been extensively analysed in vertebrates. However, members of this network are found in all animals examined so far. Several recent studies have addressed the physiological function of these proteins in invertebrate model organisms, in particular Drosophila melanogaster. This review describes the structure of invertebrate Myc/Max/Mad genes and it discusses their regulation and physiological functions, with special emphasis on their essential role in the control of cellular growth and proliferation.

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Authors and Affiliations

  1. Zoologisches Institut, Universität Zürich, Winterthurerstrasse 190, 8057, Zürich, Switzerland

    P. Gallant

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  1. P. Gallant
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  1. Division of Basic Sciences, Fred Hutchinson Cancer Research Center, P.O. Box 19024, Seattle, Washington, 98108-1024, USA

    R. N. Eisenman Ph.D.

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Gallant, P. (2006). Myc/Max/Mad in Invertebrates: The Evolution of the Max Network. In: Eisenman, R.N. (eds) The Myc/Max/Mad Transcription Factor Network. Current Topics in Microbiology and Immunology, vol 302. Springer, Berlin, Heidelberg. https://doi.org/10.1007/3-540-32952-8_9

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