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Rationale for Antibiotic Prophylaxis in Open Fractures

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References

  1. Worlock P, Slack R, Harvey L, Mawhinney R. The prevention of infection in open fractures: an experimental study of the effect of fracture stability. Injury 1994; 25(1): 31–38

    Article  CAS  PubMed  Google Scholar 

  2. Burke JF. The effective period of preventive antibiotic action in experimental infections and dermal lesions. Surgery 1961; 50: 161–168

    Google Scholar 

  3. Patzakis MJ, Harvey JP Jr, Ivler D. The rôle of antibiotics in the management of open fractures. J Bone Joint Surg Am 1974; 56(3): 532–541

    CAS  PubMed  Google Scholar 

  4. Bergman BR. Antibiotic prophylaxis in open and closed fractures: a controlled clinical trial. Acta Orthop Scand 1982; 53(1): 57–62

    CAS  PubMed  Google Scholar 

  5. Braun R, Enzler MA, Rittmann WW. A double blind clinical trial of prophylactic cloxacillin in open fractures. J Orthop Trauma 1987; 1: 12–17

    CAS  PubMed  Google Scholar 

  6. Gustilo RB, Mendoza RM, Williams DN. Problems in the management of type III (severe) open fractures: a new classification of type III open fractures. J Trauma 1984; 24: 741–746

    Google Scholar 

  7. Dellinger EP, Miller SD, Wertz MJ, Grypma M, Roppert B, Anderson PA. Risk of infection after open fracture of the arm or leg. Arch Surg 1988; 123: 1320–1327

    CAS  PubMed  Google Scholar 

  8. Gustilo RB, Merkow RL, Templeman D. Current concept review: the management of open fractures. J Bone Joint Surg 1990; 72A: 299–304

    Google Scholar 

  9. Patzakis MJ, Wilkins J, Moore TM. Considerations in reducing the infection rate in open tibial fractures. Clin Orthop 1983b; 178: 36–41

    PubMed  Google Scholar 

  10. Gagey O, Doyon F, Dellamonica P, Carsenti-Etesse H, Desplaces N. Prophylaxie des infections dans les fractures ouvertes de jambe. Rev Chir Orthop 1999; 85: 328–336

    CAS  PubMed  Google Scholar 

  11. Valenziano CP, Chattar-Cora D, O’Neill A, Hubli EH, Cudjoe EA. Efficacy of primary wound cultures in long bone open extremity fractures: are they of any value? Arch Orthop Trauma Surg 2002; 122(5): 259–261

    Article  PubMed  Google Scholar 

  12. Vasenius J, Tulikoura I, Vainionpaa S, Rokkaken P. Clindamycin versus cloxacillin in the treatment of 240 open fractures. A randomized prospective study. Ann Chir Gynaecol 1998; 87(3): 224–228

    CAS  PubMed  Google Scholar 

  13. Patzakis MJ, Bains RS, Lee J, Schepherd L, Singer G, Ressler R, Harvey F, Holtom P. Prospective randomized, double blind study comparing single agent antibiotic therapy, ciprofloxacin, to combination antibiotic therapy in open fracture wounds. J Orthop Trauma 2000; 14(8): 529–533

    CAS  PubMed  Google Scholar 

  14. Tropet Y, Garbuio P, Obert L, Jeunet L, Elias B. One stage emergency treatment of open grade IIIB tibial shaft fractures with bone loss. Ann Plast Surg 2001; 46(2): 113–119

    CAS  PubMed  Google Scholar 

  15. Hertel R, Lambert SM, Muller S, Ballmer FT, Ganz R. On the timing of soft tissue reconstruction for open fractures of the lower leg. Arch Orthop Trauma Surg 1999; 119(1/2): 7–12

    CAS  PubMed  Google Scholar 

  16. Moehring HD, Gravel C, Chapman MW, Olson SA. Comparison of antibiotic beads and intravenous antibiotics in open fractures. Clin Orthop 2000; 372: 254–261

    PubMed  Google Scholar 

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© 2006 Springer Berlin · Heidelberg

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Gaudias, J. (2006). Rationale for Antibiotic Prophylaxis in Open Fractures. In: Leung, KS., et al. Practice of Intramedullary Locked Nails. Springer, Berlin, Heidelberg. https://doi.org/10.1007/3-540-32345-7_28

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  • DOI: https://doi.org/10.1007/3-540-32345-7_28

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-540-25349-5

  • Online ISBN: 978-3-540-32345-7

  • eBook Packages: MedicineMedicine (R0)

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