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High-Field Neuroimaging in Parkinson’s Disease

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High Field Brain MRI

16.2 Conclusions

By virtue of greater signal intensity, susceptibility arte-facts and chemical shift, 3.0 T MR imagers with advanced techniques have provided promising results for the study of PD that could not be obtained with standard magnets. Microstructural, metabolic and functional data will, as never before, contribute to the early diagnosis and follow-up of PD.

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References

  1. Adachi M, Hosoya T, Haku T, et al. (1999) Evaluation of the substantia nigra in patients with Parkinsonian syndrome accomplished using multishot diffusion-weighted MR imaging. Am J Neuroradiol 20:1500–1506

    PubMed  CAS  Google Scholar 

  2. Alexander GE, DeLong MR, Strick PL (1986) Parallel organization of functionally segregated circuits linking basal ganglia and cortex. Annu Rev Neurosci 9:357–381

    Article  PubMed  CAS  Google Scholar 

  3. Antonini A, Leenders KL, Meier D, et al. (1993) T2 relaxation time in patients with Parkinson’s disease. Neurology 43:697–700

    PubMed  CAS  Google Scholar 

  4. Bartzokis G, Cummings JL, Markham CH, et al. (1999) MRI evaluation of brain iron in earlier-and later-onset Parkinson’s disease and normal subjects. Magn Reson Imaging 17:213–222

    Article  PubMed  CAS  Google Scholar 

  5. Brooks DJ (2004) Neuroimaging in Parkinson’s disease. NeuroRx 1:243–254

    Article  PubMed  Google Scholar 

  6. Burton EJ, McKeith IG, Burn DJ, et al. (2004) Cerebral atrophy in Parkinson’s disease with and without dementia: a comparison with Alzheimer’s disease, dementia with Lewy bodies and controls. Brain 127:791–800

    Article  PubMed  Google Scholar 

  7. Eckert T, Sailer M, Kaufmann J, et al. (2004) Differentiation of idiopathic Parkinson’s disease, multiple system atrophy, progressive supranuclear palsy, and healthy controls using magnetization transfer imaging. Neuroimage 21:229–235

    Article  PubMed  Google Scholar 

  8. Graham JM, Paley MN, Grunewald RA, et al. (2000) Brain iron deposition in Parkinson’s disease imaged using the PRIME magnetic resonance sequence. Brain 123(12):2423–2431

    Article  PubMed  Google Scholar 

  9. Haslinger B, Erhard P, Kampfe N, et al. (2001) Event-related functional magnetic resonance imaging in Parkinson’s disease before and after levodopa. Brain 124:558–570

    Article  PubMed  CAS  Google Scholar 

  10. Hu MT, White SJ, Herlihy AH, et al. (2001) A comparison of (18)F-dopa PET and inversion recovery MRI in the diagnosis of Parkinson’s disease. Neurology 56:1195–1200

    PubMed  CAS  Google Scholar 

  11. Hughes AJ, Daniel SE, Kilford L, Lees AJ (1992) Accuracy of clinical diagnosis of idiopathic Parkinson’s disease: a clinico-pathological study of 100 cases. J Neurol Neurosurg Psychiatry 55:181–184

    PubMed  CAS  Google Scholar 

  12. Hutchinson M, Raff U (2000) Structural changes of the substantia nigra in Parkinson’s disease as revealed by MR imaging. Am J Neuroradiol 21:697–701

    PubMed  CAS  Google Scholar 

  13. Hutchinson M, Raff U, Lebedev S (2003) MRI correlates of pathology in parkinsonism: segmented inversion recovery ratio imaging (SIRRIM). Neuroimage 20:1899–1902

    Article  PubMed  Google Scholar 

  14. Jahanshahi M, Jenkins IH, Brown RG, et al. (1995) Self-initiated versus externally triggered movements. I. An investigation using measurement of regional cerebral blood flow with PET and movement-related potentials in normal and Parkinson’s disease subjects. Brain 118(4):913–933

    PubMed  Google Scholar 

  15. Kosta P, Argyropoulou MI, Markoula S, Konitsiotis S (2005) MRI evaluation of the basal ganglia size and iron content in patients with Parkinson’s disease. J Neurol (in press)

    Google Scholar 

  16. Lehericy S, Ducros M, Van de Moortele PF, et al. (2004) Diffusion tensor fiber tracking shows distinct corticostriatal circuits in humans. Ann Neurol 55:522–529

    Article  PubMed  Google Scholar 

  17. Oikawa H, Sasaki M, Tamakawa Y, et al. (2002) The substantia nigra in Parkinson disease: proton density-weighted spin-echo and fast short inversion time inversion-recovery MR findings. Am J Neuroradiol 23:1747–1756

    PubMed  Google Scholar 

  18. Playford ED, Jenkins IH, Passingham RE, et al. (1992) DJ impaired mesial frontal and putamen activation in Parkinson’s disease: a positron emission tomography study. Ann Neurol 32:151–161

    Article  PubMed  CAS  Google Scholar 

  19. Rademacher J, Engelbrecht V, Burgel U, et al. (1999) Measuring in vivo myelination of human white matter fiber tracts with magnetization transfer MR. Neuroimage 9:393–406

    Article  PubMed  CAS  Google Scholar 

  20. Rascol O, Sabatini U, Chollet F, et al. (1992) Supplementary and primary sensory motor area activity in Parkinson’s disease. Regional cerebral blood flow changes during finger movements and effects of apomorphine. Arch Neurol 49:144–148

    PubMed  CAS  Google Scholar 

  21. Rascol O, Sabatini U, Chollet F, et al. (1994) Normal activation of the supplementary motor area in patients with Parkinson’s disease undergoing long-term treatment with levodopa. J Neurol Neurosurg Psychiatry 57:567–571

    Article  PubMed  CAS  Google Scholar 

  22. Ryvlin P, Broussolle E, Piollet H, et al. (1995) Magnetic resonance imaging evidence of decreased putamenal iron content in idiopathic Parkinson’s disease. Arch Neurol 52:583–588

    PubMed  CAS  Google Scholar 

  23. Sabatini U, Boulanouar K, Fabre N, et al. (2000) Cortical motor reorganization in akinetic patients with Parkinson’s disease: a functional MRI study. Brain 123(2):394–403

    Article  PubMed  Google Scholar 

  24. Samuel M, Ceballos-Baumann AO, Boecker H, Brooks DJ (2001) Motor imagery in normal subjects and Parkinson’s disease patients: an H2 15O PET study. Neuroreport 12:821–828

    Article  PubMed  CAS  Google Scholar 

  25. Schocke MF, Seppi K, Esterhammer R, et al. (2002) Diffusion-weighted MRI differentiates the Parkinson variant of multiple system atrophy from PD. Neurology 58:575–580

    PubMed  CAS  Google Scholar 

  26. Schocke MF, Seppi K, Esterhammer R, et al. (2004) Trace of diffusion tensor differentiates the Parkinson variant of multiple system atrophy and Parkinson’s disease. Neuroimage 21:1443–1451

    Article  PubMed  Google Scholar 

  27. Seppi K, Schocke MF, Donnemiller E, et al. (2004) Comparison of diffusion-weighted imaging and [123I]IBZM-SPECT for the differentiation of patients with the Parkinson variant of multiple system atrophy from those with Parkinson’s disease. Mov Disord 19:1438–1445

    Article  PubMed  Google Scholar 

  28. Seppi K, Schocke MF, Esterhammer R, et al. (2003) Diffusion-weighted imaging discriminates progressive supranuclear palsy from PD, but not from the Parkinson variant of multiple system atrophy. Neurology 60:922–927

    PubMed  CAS  Google Scholar 

  29. Summerfield C, Junque C, Tolosa E, et al. (2005) Structural brain changes in Parkinson disease with dementia: a voxel-based morphometry study. Arch Neurol 62:281–285

    Article  PubMed  Google Scholar 

  30. Ye FQ, Allen PS, Martin WR (1996) Basal ganglia iron content in Parkinson’s disease measured with magnetic resonance. Mov Disord 11:243–249

    Article  PubMed  CAS  Google Scholar 

  31. Youdim MB, Riederer P (2004) A review about brain iron in normal and pathological conditions. In: Encyclopedia of neuroscience. Elsevier, Amsterdam

    Google Scholar 

  32. Zecca L, Youdim MB, Riederer P, et al. (2004) Iron, brain ageing and neurodegenerative disorders. Nat Rev Neurosci 5:863–873

    Article  PubMed  CAS  Google Scholar 

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Péran, P., Luccichenti, G., Cherubini, A., Hagberg, G.E., Sabatini, U. (2006). High-Field Neuroimaging in Parkinson’s Disease. In: Salvolini, U., Scarabino, T. (eds) High Field Brain MRI. Springer, Berlin, Heidelberg. https://doi.org/10.1007/3-540-31776-7_16

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  • DOI: https://doi.org/10.1007/3-540-31776-7_16

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-540-31775-3

  • Online ISBN: 978-3-540-31776-0

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