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Replication and Translation of Epigenetic Information

  • Chapter
DNA Methylation: Basic Mechanisms

Part of the book series: Current Topics in Microbiology and Immunology ((CT MICROBIOLOGY,volume 301))

Abstract

Most cells in multicellular organisms contain identical genetic information but differ in their epigenetic information. The latter is encoded at the molecular level by post-replicative methylation of certain DNA bases (in mammals 5-methyl cytosine at CpG sites) and multiple histone modifications in chromatin. In addition, higher-order chromatin structures are generated during differentiation, which might impact on genome expression and stability. The epigenetic information needs to be “translated” in order to define specific cell types with specific sets of active and inactive genes, collectively called the epigenome. Once established, the epigenome needs to be “replicated” at each cell division cycle, i.e., both genetic and epigenetic information have to be faithfully duplicated, which implies a tight coordination between the DNA replication machinery and epigenetic regulators. In this review, we focus on the molecules and mechanisms responsible for the replication and translation of DNA methylation in mammals as one of the central epigenetic marks.

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Authors and Affiliations

  1. Max Delbrück Center for Molecular Medicine, FVK, Wiltbergstr. 50, 13125, Berlin, Germany

    A. Brero, H. Leonhardt & M. C. Cardoso

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  1. A. Brero
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  2. H. Leonhardt
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  3. M. C. Cardoso
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  1. Institut für Genetik, Universität zu Köln, Zülpicher Str. 47, 50674, Köln, Germany

    Walter Doerfler (Prof. Dr.) & Petra Böhm (Prof. Dr.) & 

  2. Institut für Klinische und Molekulare Virologie, Universität Erlangen, Schlossgarten 4, 91054, Erlangen, Germany

    Walter Doerfler (Prof. Dr.) (Prof. Dr.)

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© 2006 Springer-Verlag Berlin Heidelberg

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Brero, A., Leonhardt, H., Cardoso, M.C. (2006). Replication and Translation of Epigenetic Information. In: Doerfler, W., Böhm, P. (eds) DNA Methylation: Basic Mechanisms. Current Topics in Microbiology and Immunology, vol 301. Springer, Berlin, Heidelberg. https://doi.org/10.1007/3-540-31390-7_2

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