Zusammenfassung
Verschiedene klinische Beobachtungen unterstützen die Vermutung, daß das Immunsystem bei der Bekämpfung von Tumorzellen eine wichtige Rolle spielt. Hierzu zählen
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das sporadische Auftreten von spontanen Tumorremissionen im natürlichen Verlauf einer Tumorerkrankung,
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die erhöhte Inzidenz von Malignomen unter intensiver immunsuppressiver Therapie,
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die Wirksamkeit einer immunmodulatorischen Therapie mit IFN-α und IL-2 bei Patienten mit Melanom oder Nierenzellkarzinom sowie
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der Graft-versus-Leukemia-Effekt durch Spenderlymphozyten-Infusionen nach allogener hämatopoietischer Stammzelltransplantation.
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Literatur
Brossart P, Wirths S, Stuhler G et al (2000) Induction of cytotoxic T-lymphocyte responses in vivo after vaccination with peptide-pulsed dendritic cells. Blood 96:3102–3108
Fong L, Hou Y, Rivas A et al (2001) Altered peptide ligand vaccinationwith Flt3 ligand expanded dendritic cells for tumor immunotherapy. Proc Natl Acad Sci USA 98:8809–8814
Heiser A, Coleman D, Dannull J et al (2002) Autologous dendritic cells transfected with prostate-specific antigen RNA stimulate CTL responses against metastatic prostate tumors. J Clin Invest 109:409–417
Herr W, Linn B, Leister N et al (1997) The use of computer-assisted video image analysis for the quantification of CD8+ T lymphocytes producing TNF-α spots in response to peptide antigens. J Immunol Methods 203:141–152
Jäger E, Ringhoffer M, Dienes HP et al (1996) GM-CSF enhances immune responses to melanoma-associated peptides in vivo. Int J Cancer 67:54–62
Jäger E, Gnjatic S, Nagata Y et al (2000) Induction of primary NY-ESO-1 immunity: CD8+ T lymphocyte and antibody responses in peptide-vaccinated patients with NY-ESO-1+ cancers. Proc Natl Acad Sci USA 97:12198–12203
Kuball J, Schuler M, Antunes Ferreira E et al (2002) Generating p53-specific cytotoxic T lymphocytes by recombinant adenoviral vector-based vaccination in mice, but not man. Gene Ther 9:833–843
Marchand M, van Baren N, Weynants P et al (1999) Tumor regressions observed in patients with metastatic melanoma treated with an antigenic peptide encoded by gene MAGE-3 and presented by HLA-A1. Int J Cancer 80:219–230
Meyer RG, Wölfel T. A phase I vaccination study with Tyrosinase in patients with stage II melanoma using recombinant modified vaccinia Ankara (MVA-hTyr) administered by three subcutaneous and intradermal injections. Manuskript in Vorbereitung
Renkvist N, Castelli C, Robbins PF et al (2001) A listing of human tumor antigens recognized by T cells. Cancer Immunol Immunother 50:3–15
Renner C, Kubuschok B, Trümper L et al (2001) Clinical approaches to vaccination in oncology. Ann Hematol 80:255–266
Rosenberg SA, Yang JC, Schwartzentruber DJ et al (1998) Immunologic and therapeutic evaluation of a synthetic peptide vaccine for the treatment of patients with metastatic melanoma. Nature Med 4:321–327
Thurner B, Haendle I, Röder C et al (1999) Vaccination with Mage-3A1 peptidepulsed mature, monocyte-derived dendritic cells expands specific cytotoxic T cells and induces regression of some metastases in advanced stage IV melanoma. J Exp Med 190:1669–1678
Timmerman JM, Czerwinski DK, Davis TA et al (2002) Idiotype-pulsed dendritic cell vaccination for B-cell lymphoma: clinical and immune responses in 35 patients. Blood 99:1517–1526
Titzer S, Christensen O, Manzke O et al (2000) Vaccination of multiple myeloma patients with idiotype-pulsed dendritic cells: immunological and clinical aspects. Br J Haematol 108:805–816
Van den Eynde BJ, van der Bruggen P (1997) T cell defined tumor antigens. Curr Opin Immunol 9:684–693
Yee C, Riddell SR, Greenberg PD (2001) In vivo tracking of tumor-specific T cells. Curr Opin Immunol 13:141–146
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Herr, W., Huber, C. (2006). Tumorvakzine. In: Schmoll, HJ., Höffken, K., Possinger, K. (eds) Kompendium Internistische Onkologie. Springer, Berlin, Heidelberg. https://doi.org/10.1007/3-540-31303-6_43
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DOI: https://doi.org/10.1007/3-540-31303-6_43
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