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Akute und chronische Toxizität der Strahlentherapie

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Kompendium Internistische Onkologie

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Zusammenfassung

Durch Veränderung der zellulären Strukturen, insbesondere der DNS und der Zellkernmembranen, können ionisierende Strahlen die Zellfunktion beeinträchtigen. Es kommt zu letalen, subletalen oder potentiell letalen Strahlenschäden an Tumor- und Normalgeweben. Subletale und potentiell letale Ereignisse werden u.U. repariert, im Tumor seltener und langsamer als im Normalgewebe. Bei einem letalen Schaden sterben die Zellen ab, entweder im betreffenden Zellzyklus oder erst im Verlauf weiterer Zellteilungen (Interphase- oder reproduktiver Zelltod, ausführlichere Darstellung bei Sauer 2003 oder Fritz-Niggli 1997).

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Authors
  1. R. Sauer
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  2. L. Keilholz
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Editors and Affiliations

  1. Schwerpunkt Hämatologie/Onkologie, Martin-Luther-Universität Halle-Wittenberg, Ernst-Grube-Straße 40, 06120, Halle/Saale

    Hans-Joachim Schmoll (Direktor der Klinik und Poliklinik für Innere Medizin IV) (Direktor der Klinik und Poliklinik für Innere Medizin IV)

  2. Onkologie-Hämatologie-Gastroenterologie-Hepatologie-Infektiologie, Klinikum der Friedrich-Schiller-Universität Jena, Erlanger Allee 101, 07740, Jena

    Klaus Höffken (Direktor der Klinik und Poliklinik für Innere Medizin II) (Direktor der Klinik und Poliklinik für Innere Medizin II)

  3. Schwerpunkt Onkologie und Hämatologie, Universitätsmedizin Berlin, Charité-Campus Mitte Schumannstraße 20/21, 10117, Berlin

    Kurt Possinger (Direktor der Medizinischen Klinik II) (Direktor der Medizinischen Klinik II)

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© 2006 Springer Medizin Verlag Heidelberg

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Sauer, R., Keilholz, L. (2006). Akute und chronische Toxizität der Strahlentherapie. In: Schmoll, HJ., Höffken, K., Possinger, K. (eds) Kompendium Internistische Onkologie. Springer, Berlin, Heidelberg. https://doi.org/10.1007/3-540-31303-6_39

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  • DOI: https://doi.org/10.1007/3-540-31303-6_39

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-540-20657-6

  • Online ISBN: 978-3-540-31303-8

  • eBook Packages: Medicine (German Language)

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