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Spontanremissionen

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Kompendium Internistische Onkologie

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Zusammenfassung

Bis vor wenigen Jahren stand fast ausschließlich die unkontrollierte Proliferation von malignen Zellen im Brennpunkt der klinischen und experimentellen Onkologie. Das gängige Malignommodell mit exponentiellem klonalem Wachstum orientierte sich implizit an der mechanistischen Katastrophenanalogie eines losgelösten Schneeballs, der in einer entsprechenden Umgebung zu einer unhaltsam destruktiven Lawine anwächst.

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Literatur

  • Abel U (2001) Spontanremissionen aus biometrischer Sicht. Dtsch Z Onkol 33:115–126

    Article  Google Scholar 

  • Abubakr YA, Chou TH, Redman BD (1994) Spontaneous remission of renal cell carcinoma: a case report and immunological correlates. J Urol 152:156–157

    PubMed  CAS  Google Scholar 

  • Alvinoach I, Aflalo E (1992) Human melanoma cell lines established from metastases of a patient with a completely regressed primary site. Cancer 69:113–122

    Article  Google Scholar 

  • Atkins MB, Mier JW, Gould JA et al (1988) Hypothyroidism and tumor regression. N Engl J Med 319:1351

    Article  Google Scholar 

  • Beguin Y, Callignon J, Laurent C, Fillet G (1996) Spontaneous complete remission and recovery of donor haemopoiesis without GVHD after relapse and apparent marrow graft rejection in poor-prognosis myelodysplastic syndrome. Br J Haematol 94:507–509

    Article  PubMed  CAS  Google Scholar 

  • Beljaards RC, Kaudewitz P, Berti E et al (1993) Primary cutaneous CD30-positive large cell lymphoma: definition of a new type of cutaneous lymphoma with a favorable prognosis. Cancer 71:2097–2104

    Article  PubMed  CAS  Google Scholar 

  • Berland W (1995) Can the self affect the course of cancer? Unexpected cancer recovery: Why patients believe they survive. Adv Mind Body Med 11:5–19

    Google Scholar 

  • Berthold F, Hero B, Breu H et al (1996) The recurrence patterns of stages I, II and III neuroblastomas: experience with 77 relapsing patients. Ann Oncol 7:183–187

    PubMed  CAS  Google Scholar 

  • Bowles APJr, Perkins E (1999) Long-term remission of malignant brain tumors after intracranial infection: a report of four cases. Neurosurgery 44:636–642

    Article  PubMed  Google Scholar 

  • Carlson NLT (1990) How frequent is spontaneous remission of neuroblastomas? Implications for screening. Br J Cancer 61:441–446

    Google Scholar 

  • Challis GB, Stam HJ (1990) The spontaneous regression of cancer — a review of cases from 1900–1987. Acta Oncol 29:545–550

    Article  PubMed  CAS  Google Scholar 

  • Coates AS, Segelov E (1994) Long-term response to chemotherapy in patients with visceral metastatic melanoma. Ann Oncol 5:249–251

    PubMed  CAS  Google Scholar 

  • Cole WH (1981) Efforts to explain spontaneous regression of cancer. J Surg Oncol 17:201–209

    Article  PubMed  CAS  Google Scholar 

  • Creutzig U, Baumann M(1998) Spontaneous remission in neonates with Down’s syndrome and acute myelogenous leukemia — transient myeloproliferative disease. Onkologie 21(3):184–188

    Google Scholar 

  • Cunningham AJ (1996) An experimental approach to the mind/body question. Adv Mind Body Med 12:58–71

    Google Scholar 

  • Czerny V (1907) Über unerwartete Krebsheilungen. Zschr f Krebsforsch 3(3):27–35

    Article  Google Scholar 

  • Diekman MJM, Bresser P, Noorduyn LA, Reiss P (1992) Spontaneous regression of Ki-positive T-cell non-Hodgkin’s lymphoma in a patient with HIV infection. Br J Haemat 82:477–478

    Article  CAS  Google Scholar 

  • Drobyski WR, Quazi R (1989) Spontaneous regression in Non-Hodgkin’s lymphoma: Clinical and pathogenetic consideration. Am J Hematol 31:138–141

    Article  PubMed  CAS  Google Scholar 

  • Edwards MJ, Anderson JA, Angel JR, Harty JI (1996) Spontaneous regression of primary and metastatic renal cell carcinoma. J Urol 155:1385

    Article  PubMed  CAS  Google Scholar 

  • Everson TC, Cole WH (1966) Spontaneous Regression of Cancer. Saunders, Philadelphia

    Google Scholar 

  • Fairlamb DJ (1981) Spontaneous regression of metastases of renal cancer. A report of two cases including the first recorded regression following irradiation of a dominant metastasis and review of the world literature. Cancer 47:2102–2106

    Article  PubMed  CAS  Google Scholar 

  • Folkman J (1997a) Antiangiogenic therapy. In: DeVita VT, Hellman S, Rosenberg SA (eds) Cancer — Principles and Practice of Oncology. Lippincott-Raven, Philadelphia New York, pp 3075–3085

    Google Scholar 

  • Folkman J (1997b) Antiangiogenic therapy: experimental and clinical studies. Key note lecture, 39th Annual Meeting of the American Society of Hematology (ASH), San Diego, December 5–9, 1997

    Google Scholar 

  • Frick S, Frick P (1993) Spontanremission bei chronischer lymphatischer Leukämie. Schweiz Med Wochenschr 123:328–334

    PubMed  CAS  Google Scholar 

  • Gallmeier WM(1997) Spontanremissionen bei Krebs. Was wir daraus lernen können. MMW 139:657–659

    Google Scholar 

  • Gattiker HH, Wiltshaw E, Galton DAG (1980) Spontaneous regression in non-Hodgkin’s lymphoma. Cancer 45:2627–2632

    Article  PubMed  CAS  Google Scholar 

  • Giralt S, Hester J, Huh Y et al (1995) CD8-depleted donor lymphocyte infusion as treatment for relapsed chronic myelogenous leukemia after allogenic bone marrow transplantation. Blood 86:4337–4343

    PubMed  CAS  Google Scholar 

  • Gleave ME, Elhilau M, Fradet, Elhilau M, Fradet Y et al (1998) Interferon gamma-1b compared with placebo in metastatic renal-cell carcinoma. N Engl J Med 338:1265–1271

    Article  PubMed  CAS  Google Scholar 

  • Haas D, Ablin AR, Miller C et al (1988) Complete pathologic maturation and regression of stage IVs neuroblastoma without treatment. Cancer 62:818–825

    Article  PubMed  CAS  Google Scholar 

  • Hartwell LH, Kastan MB (1994) Cell cycle control and cancer. Science 266:1821–1828

    Article  PubMed  CAS  Google Scholar 

  • Hiyama E, Hiyama K, Yokoyama T et al (1995) Correlating telomerase activity levels with human neuroblastoma outcomes. Nature Med 1:249–255

    Article  PubMed  CAS  Google Scholar 

  • Hoehner JE, Hedborg F, Jernberg Wiklund H et al (1995) Cellular death in neuroblastoma: in situ correlation of apoptosis and bcl-2 expression. Int J Cancer 62:19–24

    Article  PubMed  CAS  Google Scholar 

  • Holmgren L, O’Reilly MS, Folkman J (1995) Dormancy of micrometastasis: Balanced proliferation and apoptosis in the presence of antiangiogenesis suppression. Nat Med 1:149–153

    Article  PubMed  CAS  Google Scholar 

  • Horning SJ, Rosenberg SA (1984) The natural history of initially untreated low-grade non-Hodgkin’s lymphomas. N Engl J Med 311:1471–1475

    PubMed  CAS  Google Scholar 

  • Hornstein O, Mülke G (1960) Kutan metastasierendes Neuroblastoma sympathicum mit „spontan“ regressivem Verlauf. Dermatologica 120:35–52

    Article  PubMed  CAS  Google Scholar 

  • Ifrah N, James JM, Vigue F et al (1985) Spontaneous remission in adult acute leukemia. Cancer 56:1187–1190

    Article  PubMed  CAS  Google Scholar 

  • Jeha S, Chan KW, Aprikyan AG et al (2000) Spontaneous remission of granulocyte colony-stimulating factor-associated leukemia in a child with severe congenital neutropenia. Blood 96:3647–3649

    PubMed  CAS  Google Scholar 

  • Kappauf H, Büschel G, Kaiser G, Gallmeier WM (1998) Dokumentation von Spontanremissionen bei Krebserkrankungen durch die Nürnberger Arbeitsgruppe Biologische Krebstherapie — Auswertung von Laienberichten. In: Heim ME, Schwarz R (Hrsg) Spontanremissionen in der Onkologie. Schattauer, Stuttgart: 57–65

    Google Scholar 

  • Kappauf H, Gallmeier WM, Wünsch P et al (1997) Spontaneous remission of metastases in a patient with non-small cell lung cancer. Ann Oncol 8:1031–1039

    Article  PubMed  CAS  Google Scholar 

  • Kappauf H (1997) Spontanremissionen bei Krebs. MMW 139:660–664

    Google Scholar 

  • Kappauf H (1998) Spontanremissionen von Malignomen — 15 neue Fülle. In: Heim ME, Schwarz R (Hrsg) Spontanremissionen in der Onkologie. Schattauer, Stuttgart:172–192

    Google Scholar 

  • Kappauf H (2003) Wunden sind möglich. Spontanremissionen bei Krebs. Herder, Freiburg: 1–192

    Google Scholar 

  • Karnad AB, Jaffar A, Lands RH (1992) Spontaneous regression of acquired immune deficiency syndrome-related high grade, extranodal non-Hodgkin’s lymphoma. Cancer 69:1856–1857

    Article  PubMed  CAS  Google Scholar 

  • Kashiwabara K et al (1999) Ki-1 (CD30)-positive anaplastic large cell lymphoma, sarcomatoid variant accompanied by spontaneously regressing lymphadenopathy. Intern Med 38:49–53

    Article  PubMed  CAS  Google Scholar 

  • Kaufmann Y, Many A, Rechavi G et al (1995) Brief report: Lymphoma with recurrent cycles of spontaneous remission and relapse — possible role of apoptosis. N Engl J Med 332:507–510

    Article  PubMed  CAS  Google Scholar 

  • Kavoussi LR, Levine SR, Kadmon D, Fair WR (1986) Regression of metastatic renal cell carcinoma: a case report and literature review. J Urol 135:1005–1007

    PubMed  CAS  Google Scholar 

  • Kennedy BJ (1976) Psychological response of patients cured of advanced cancer. Cancer 38:2184–2191

    Article  PubMed  CAS  Google Scholar 

  • Kolb HJ, Mittermüller J, Clemm C et al (1990) Donor leucocyte transfusions for treatment of recurrent myelogenous leukemia in marrow transplant patients. Blood 76:2462–2465

    PubMed  CAS  Google Scholar 

  • Kraus M, Wolf B (1998) Physicochemical microenvironment as key regulator for tumor microevolution, invasion, and immune response: targets for endocytotechnological approaches in cancer treatment. Endocytobiosis 156

    Google Scholar 

  • Kumamoto M, Nakamine H, Hara T et al (1994) Spontaneous complete regression of high-grade non-Hodgkin’s lymphoma. Morphologic, immunhistochemical and gene amplification analyses. Cancer 74:3023–3028

    Article  PubMed  CAS  Google Scholar 

  • Lassen U, Osterlind K, Hansen M et al (1995) Long-term survival in small-cell lung cancer: posttreatment characteristics in patients surviving 5 to 18+ years. An analysis of 1,714 consecutive patients. J Clin Oncol 13:1215–1220

    PubMed  CAS  Google Scholar 

  • Lowy ADJr, Erickson ER (1986) Spontaneous 19-year regression of oat cell carcinoma with scalene node metastasis. Cancer 58:978–980

    Article  PubMed  Google Scholar 

  • Matsushita K et al (1999) Spontaneous regression associated with apoptosis in a patient with acute-type adult T-cell leukemia. Am J Hematol 61:144–148

    Article  PubMed  CAS  Google Scholar 

  • Maurer S, Kölmel KF (1998) Spontaneous regression of advanced malignant melanoma. Oncology 21(1):14–18

    Article  Google Scholar 

  • Millauer B, Shawver LK, Plate KH et al (1994) Glioblastoma growth inhibited in vivo by a dominant-negative Flk-1 mutant. Nature 367:576–579

    Article  PubMed  CAS  Google Scholar 

  • Mitterbauer M, Fritzer-Szekeres M, Mitterbauer G et al (1996) Spontaneous remission of acute myeloid leukemia after infection and blood transfusion associated with hypergammaglobinaemia. Ann Hematol 73:189–193

    Article  PubMed  CAS  Google Scholar 

  • Müller GA, Diem U, Fritz U et al (1989) Spontane Remission von Lungenmetastasen bei Nierenzellkarzinom. Dtsch Med Wochenschr 114:420–423

    Article  PubMed  Google Scholar 

  • Musashi M, Abe S, Yamada T et al (1997) Spontaneous remission in a patient with chronic myelogenous leukemia. N Engl J Med 336:337–339

    Article  PubMed  CAS  Google Scholar 

  • Nagel S, Borish B, Rohr A von et al (1996) Clonal analysis of a B-cell lymphoma with recurrent spontaneous remission and evolution into chronic lymphocytic leukaemia. Ann Oncol 7:953–960

    PubMed  CAS  Google Scholar 

  • Okamura S, Katsuhiko H, Satoh T (2000) Regression of rectal mucosa-associated lymphoid tissue lymphoma unrelated to Helicobacter pylori [letter]. Ann Intern Med 132:247

    PubMed  CAS  Google Scholar 

  • O’Reilly MS, Holmgren L, Chen C, Folkman J (1996) Angiostatin induces and sustains dormancy of human primary tumours in mice. Nat Med 2:689–692

    Article  PubMed  Google Scholar 

  • O’Regan B, Hirshberg C (1993) Spontaneous Remission. An Annotated Bibliography. Sausolito, Institute of Noetic Sciences

    Google Scholar 

  • Oliver RTD, Nethersell ABW, Bottomley JM (1989) Unexplained spontaneous regression and alpha-interferon as treatment for metastatic renal carcinoma. Br J Urology 63:128–131

    Article  CAS  Google Scholar 

  • Pathak S, Multani AS, McConkey DJ et al (2000) Spontaneous regression of cutaneous melanoma in sinclair swine is associated with defective telomerase activity and extensive telomerase erosion. Int J Oncol 17:1219–1224

    PubMed  CAS  Google Scholar 

  • Perez-Atayde AR, Sallan SE, Tedrow U et al (1997) Spectrum of tumor angiogenesis in the bone marrow of children with acute lymphoblastic leukemia. Ann J Pathol 150:815–821

    CAS  Google Scholar 

  • Printz C (2001) Spontaneous regression of melanoma may offer insight into cancer immunology. J Natl Cancer Inst 93:1047–1048

    Article  PubMed  CAS  Google Scholar 

  • Rae MV (1935) Spontaneous regression of a hypernephroma. Am J Cancer 24:839–841

    Google Scholar 

  • Rosenberg SA, Fox E, Churchill WH (1972) Spontaneous regression of hepatic metastases from gastric carcinoma. Cancer 29:472–474

    Article  PubMed  CAS  Google Scholar 

  • Ruckdeschel JC, Codish SD, Stranahan et al (1972) Postoperative empyema improves survival in lung cancer. N Engl J Med 287:1013–1017

    PubMed  CAS  Google Scholar 

  • Salloum E, Cooper DL, Howe G et al (1996) Spontaneous regression of lymphoproliferative disorders in patients treated with methotrexate for rheumatoid arthritis and other rheumatic diseases. J Clin Oncol 1943–1949

    Google Scholar 

  • Severin T, Müller B, Giese G et al (1994) pH-dependent LAK cell cytotoxicity. Tumour Biol 15:304–310

    Article  PubMed  CAS  Google Scholar 

  • Smith RA (1971) Cure of lung cancer from incomplete surgical resection. Br Med J 2:563–565

    Article  PubMed  CAS  Google Scholar 

  • Sproujieh AS (1988) Spontaneous regression of intestinal malignant melanoma from an occult primary site. Cancer 62:1247–1250

    Article  Google Scholar 

  • Starnes CO (1992) Coley’s toxins in perspective. Nature 357:11–12

    Article  PubMed  CAS  Google Scholar 

  • Sternberg CN (1997) Cancers of the genitourinary tract. In: Cavalli F, Hansen HH, Kaye SB (eds) Textbook of Medical Oncology. Dunitz, London, pp 183–216

    Google Scholar 

  • Stoll BA (1992) Spontaneous regression of cancer: new insights. Biotherapy 4:23–30

    Article  PubMed  CAS  Google Scholar 

  • Takáts LJ, Csapó Z (1966) Death from renal carcinoma 37 years after its original recognition. Cancer 19:1172–1176

    Article  PubMed  Google Scholar 

  • Theiß R (1998) Unerklärbare Heilungen in Lourdes — Dokumentation des Internationalen Medizinischen Komitees. In: Heim M, Schwarz R (Hrsg) Spontanremissionen in der Onkologie, Schattauer, Stuttgart: 39–46

    Google Scholar 

  • Thomas R, Ribeiro I, Shepherd P et al (2002) Spontaneous clinical regression in chronic lymphocytic leukaemia. Br J Haematol 116:341–345

    PubMed  Google Scholar 

  • Trenn G, Utz D, Reis HE (1998) Spontaneous remission of a hepatocellular carcinoma. Onkologie 21:156–159

    Article  Google Scholar 

  • Tzankov A, Ludescher C, Duba HC et al (2001) Spontaneous remission in a secondary acute myelogenous leukaemia following invasive pulmonary aspergillosis. Ann Hematol 80:423–442

    Article  PubMed  CAS  Google Scholar 

  • Vogt B, Frey FJ (1997) Inhibition of angiogenesis in Kaposi’s sarcoma by captopril. Lancet 349:1148

    Article  PubMed  CAS  Google Scholar 

  • Wiegel T, Degner C, Cornely D, Runkel N (1996) Axillary metastatic spread in connection with local recurrence of a renal cell carcinoma 22 years after the first diagnosis — case report and survey of the literature. Onkologie 19:506–507

    Article  Google Scholar 

  • Yamamoto K, Hanada R, Kikuchi A et al (1998) Spontaneous regression of localized neuroblastoma detected by mass screening. J Clin Oncol 16:1265–1269

    PubMed  CAS  Google Scholar 

  • Weintraub M, Kaplinski C, Amariglio N et al (2000) Spontaneous regression of congenital leukaemia with an 8;16 translocation. Br J Haematol 111:641–643

    Article  PubMed  CAS  Google Scholar 

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Authors
  1. H. Kappauf
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  2. W. M. Gallmeier
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Editors and Affiliations

  1. Schwerpunkt Hämatologie/Onkologie, Martin-Luther-Universität Halle-Wittenberg, Ernst-Grube-Straße 40, 06120, Halle/Saale

    Hans-Joachim Schmoll (Direktor der Klinik und Poliklinik für Innere Medizin IV) (Direktor der Klinik und Poliklinik für Innere Medizin IV)

  2. Onkologie-Hämatologie-Gastroenterologie-Hepatologie-Infektiologie, Klinikum der Friedrich-Schiller-Universität Jena, Erlanger Allee 101, 07740, Jena

    Klaus Höffken (Direktor der Klinik und Poliklinik für Innere Medizin II) (Direktor der Klinik und Poliklinik für Innere Medizin II)

  3. Schwerpunkt Onkologie und Hämatologie, Universitätsmedizin Berlin, Charité-Campus Mitte Schumannstraße 20/21, 10117, Berlin

    Kurt Possinger (Direktor der Medizinischen Klinik II) (Direktor der Medizinischen Klinik II)

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Kappauf, H., Gallmeier, W.M. (2006). Spontanremissionen. In: Schmoll, HJ., Höffken, K., Possinger, K. (eds) Kompendium Internistische Onkologie. Springer, Berlin, Heidelberg. https://doi.org/10.1007/3-540-31303-6_11

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  • DOI: https://doi.org/10.1007/3-540-31303-6_11

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  • Print ISBN: 978-3-540-20657-6

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