Abstract
Molecular mimics of self-antigens can behave as altered peptide ligands and serve to ameliorate autoimmune disease. Analysis of experimental autoimmune encephalomyelitis with proteomic autoantibody microarrays reveals that there might exist a wide variety of microbes with features that mimic self-epitopes. Autoimmunity could therefore be modulated via microbial immunity, which may account for relapse and remission of ongoing disease.
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Steinman, L., Utz, P.J., Robinson, W.H. (2005). Suppression of Autoimmunity via Microbial Mimics of Altered Peptide Ligands. In: Oldstone, M.B. (eds) Molecular Mimicry: Infection-Inducing Autoimmune Disease. Current Topics in Microbiology and Immunology, vol 296. Springer, Berlin, Heidelberg. https://doi.org/10.1007/3-540-30791-5_4
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DOI: https://doi.org/10.1007/3-540-30791-5_4
Publisher Name: Springer, Berlin, Heidelberg
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