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Lymphoid Tissue Inducer Cells in Intestinal Immunity

  • Chapter
Gut-Associated Lymphoid Tissues

Part of the book series: Current Topics in Microbiology and Immunology ((CT MICROBIOLOGY,volume 308))

Abstract

During fetal development, lymphoid tissue inducer cells (LTis) seed the developing lymph node and Peyer’s patch anlagen and initiate the formation of both types of lymphoid organs. In the adult, a similar population of cells, termed lymphoid tissue inducer-like cells (LTi-like cells), supports the formation of organized gut-associated lymphoid tissue (GALT) in the intestine, including both isolated lymphoid follicles (ILFs) and cryptopatches (CPs). Both LTi and LTi-like cells require expression of the transcription factor RORγt for their differentiation and function, and mice lacking RORγt lack lymph nodes, Peyer’s patches, and other organized GALT. In ILFs and cryptopatches, LTi-like cells are in close contact with different populations of intestinal dendritic cells (DCs), including a subpopulation recently shown to extend dendrites and sample luminal microflora. This interaction may allow for communication between the intestinal lumen and the immune cells in the lamina propria, which is necessary for maintaining homeostasis between the commensal microflora and the intestinal immune system. The potential functional implications of the organization of LTi-like cells, DCs, and lymphocytes in the lamina propria are discussed in the context of maintenance of homeostasis and of infectious diseases, particularly HIV infection.

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Authors and Affiliations

  1. Howard Hughes Medical Institute, Skirball Institute of Biomolecular Medicine, New York University School of Medicine, New York, NY, 10016, USA

    I. I. Ivanov, G. E. Diehl & D. R. Littman

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  1. I. I. Ivanov
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  2. G. E. Diehl
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  3. D. R. Littman
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Editors and Affiliations

  1. Department of Immunology and Genomic Medicine, Kyoto University Graduate School of Medicine, Yoshida, Sakyo-ku, Kyoto, 606-8501, Japan

    Tasuku Honjo MD, Ph.D.

  2. Biozentrum, Department of Cell Biology, University of Basel, Klingelbergstr. 50-70, 4056, Basel, Switzerland

    Fritz Melchers

  3. Max Planck Institute for Infection Biology, Campus Charité, Schumannstrasse 21-22, 10117, Berlin, Germany

    Fritz Melchers

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Ivanov, I.I., Diehl, G.E., Littman, D.R. (2006). Lymphoid Tissue Inducer Cells in Intestinal Immunity. In: Honjo, T., Melchers, F. (eds) Gut-Associated Lymphoid Tissues. Current Topics in Microbiology and Immunology, vol 308. Springer, Berlin, Heidelberg . https://doi.org/10.1007/3-540-30657-9_3

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