Nomenclature
EC number
1.14.99.7
Systematic name
squalene,hydrogen-donor:oxygen oxidoreductase (2,3-epoxidizing)
Recommended name
squalene monooxygenase
Synonyms
hydroxylase, squalene
oxygenasem squalene mono-
squalene 2,3-oxidocyclase
squalene epoxidase
squalene hydroxylase
squalene oxydocylase (EC 1.14.99.7 together with EC 5.4.99.7, was formerly known as squalene oxydocyclase)
squalene-2,3-epoxidase
squalene-2,3-epoxide cyclase
CAS registry number
9029-62-3
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References
Tai, H.H.; Bloch, K.: Squalene epoxidase of rat liver. J. Biol. Chem., 247, 3767–3773 (1972)
Van Tamelen, E.E.; Heys, J.R.: Enzymic epoxidation of squalene variants. J. Am. Chem. Soc, 97, 1252–1253 (1975)
Ferguson, J.B.; Bloch, K.: Purification and properties of a soluble protein activator of rat liver squalene epoxidase. J. Biol. Chem., 252, 5381–5385 (1977)
Ono, T.; Bloch, K.: Solubilization and partial characterization of rat liver squalene epoxidase. J. Biol. Chem., 250, 1571–1579 (1975)
Ono, T.; Takahashi, K.; Odani, S.; Konno, H.; Imai, Y.: Purification of squalene epoxidase from rat liver microsomes. Biochem. Biophys. Res. Commun., 96, 522–528 (1980)
Astruc, M.; Tabacik, C.; Descomps, B.; Crastes de Paulet, A.: Squalene epoxidase and oxidosqualene lanosterol-cyclase activities in cholesterogenic and non-cholesterogenic tissues. Biochim. Biophys. Acta, 487, 204–211 (1977)
Jordan, D.B.: Squalene oxidase: the elusive flavoenzyme of sterol biosynthesis. Flavins and Flavoproteins (Proc. Int. Symp., 10th, Meeting Date 1990, Curti, B., Ronchi S., Zanetti, G., eds.) de Gruyter, Berlin, New York, 865–868 (1991)
Ono, T.; Nakazono, K.; Kosaka, H.: Purification and partial characterization of squalene epoxidase from rat liver microsomes. Biochim. Biophys. Acta, 709, 84–90 (1982)
Ono, T.; Imai, Y.: Squalene epoxidase from rat liver microsomes. Methods Enzymol, 110, 375–380 (1985)
M’Baya, B.; Karst, F.: In vitro assay of squalene epoxidase of Saccharomyces cerevisiae. Biochem. Biophys. Res. Commun., 147, 556–564 (1987)
Ryder, N.S.; Dupont, M.C.: Inhibition of squalene epoxidase by allylamine antimycotic compounds. A comparative study of the fungal and mammalian enzymes. Biochem. J., 230, 765–770 (1985)
Ryder, N.S.; Dupont, M.C.: Properties of a particulate squalene epoxidase from Candida albicans. Biochim. Biophys. Acta, 794, 466–471 (1984)
Lin, L.F.H.: Roles of phospholipid and detergent in soluble protein activation of squalene epoxidase. Biochemistry, 19, 5135–5140 (1980)
Satoh, T.; Horie, M.; Watanabe, H.; Tsuchiya, Y.; Kamei, T.: Enzymic properties of squalene epoxidase from Saccharomyces cerevisiae. Biol. Pharm. Bull, 16, 349–352 (1993)
Nagumo, A.; Kamei, T.; Sakakibara, J.; Ono, T.: Purification and characterization of recombinant squalene epoxidase. J. Lipid Res., 36, 1489–1497 (1995)
Favre, B.; Ryder, N.S.: Characterization of squalene epoxidase activity from the dermatophyte Trichophyton rubrum and its inhibition by terbinafine and other antimycotic agents. Antimicrob. Agents Chemother., 40, 443–447 (1996)
Laden, B.P.; Tang, Y.; Porter, T.D.: Cloning, heterologous expression, and enzymological characterization of human squalene monooxygenase. Arch. Biochem. Biophys., 374, 381–388 (2000)
Abe, I.; Kashiwagi, Y.; Noguchi, H.: Inhibition of vertebrate squalene epoxidase by isoprenyl gallates and phenylalkyl gallates. Bioorg. Med. Chem. Lett., 10, 2525–2528 (2000)
Abe, I.; Seki, T.; Umehara, K.; Miyase, T.; Noguchi, H.; Sakakibara, J.; Ono, T.: Green tea polyphenols: novel and potent inhibitors of squalene epoxidase. Biochem. Biophys. Res. Commun., 268, 767–771 (2000)
Abe, I.; Seki, T.; Noguchi, H.; Kashiwada, Y.: Galloyl esters from rhubarb are potent inhibitors of squalene epoxidase, a key enzyme in cholesterol biosynthesis. Planta Med., 66, 753–756 (2000)
Sawada, M.; Matsuo, M.; Hagihara, H.; Tenda, N.; Nagayoshi, A.; Okumura, H.; Washizuka, K.; Seki, L; Goto, T.: Effect of FR194738, a potent inhibitor of squalene epoxidase, on cholesterol metabolism in HepG2 cells. Eur. J. Pharmacol., 431, 11–16 (2001)
Laden, B.P.; Porter, T.D.: Inhibition of human squalene monooxygenase by tellurium compounds: evidence of interaction with vicinal sulfhydryls. J. Lipid Res., 42, 235–240 (2001)
Gupta, N.; Porter, T.D.: Inhibition of human squalene monooxygenase by selenium compounds. J. Biochem. Mol. Toxicol., 16, 18–23 (2002)
Wentzinger, L.F.; Bach, T.J.; Hartmann, M.A.: Inhibition of squalene synthase and squalene epoxidase in tobacco cells triggers an up-regulation of 3-hydroxy-3-methylglutaryl coenzyme A reductase. Plant Physiol., 130, 334–346 (2002)
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(2006). Squalene monooxygenase. In: Schomburg, D., Schomburg, I. (eds) Springer Handbook of Enzymes. Springer Handbook of Enzymes, vol 27. Springer, Berlin, Heidelberg. https://doi.org/10.1007/3-540-30439-8_34
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