Nomenclature
EC number
1.14.21.4
Systematic name
(R)-reticuline,NADPH:oxygen oxidoreductase (C-C phenol-coupling)
Recommended name
salutaridine synthase
Synonyms
(R)-reticuline dehydrogenase
(R)-reticuline oxidase (C-C phenol-coupling)
EC 1.1.3.35 (formerly)
dehydrogenase, (R)-reticuline
CAS registry number
149433-84-1
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References
Gerardy R.; Zenk, M.H.: Formation of salutaridine from (R)-reticuline by a membrane-bound cytochrome P-450 enzyme from Papaver somniferum. Phytochemistry, 32, 79–86 (1993)
Amann, T.; Roos, P.H.; Huh, H.; Zenk, M.H.: Purification and characterization of a cytochrome p450 enzyme from pig liver, catalyzing the phenol oxidative coupling of (R)-reticuline to salutaridine, the critical step in morphine biosynthesis. Heterocycles, 1, 425–440 (1995)
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(2006). Salutaridine synthase. In: Schomburg, D., Schomburg, I. (eds) Springer Handbook of Enzymes. Springer Handbook of Enzymes, vol 27. Springer, Berlin, Heidelberg. https://doi.org/10.1007/3-540-30439-8_26
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DOI: https://doi.org/10.1007/3-540-30439-8_26
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