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Skeletal Muscle

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Mechanisms of Sepsis-Induced Organ Dysfunction and Recovery

Part of the book series: Update in Intensive Care and Emergency Medicine ((UICMSOFT,volume 44))

Conclusion

Skeletal muscle is a significant player in MOF, showing marked metabolic and structural changes and contributing to the metabolic and inflammatory fluxes in the body. Muscle function is severely compromised, but muscle is a resilient organ and shows an excellent ability to recovery. As a highly plastic organ, muscle shows marked adaptation to activity levels and immobility, and in situations of whole body stress provides a major store of amino acids through controlled degradation. However, muscle provision of certain, conditionally essential amino acids can become limiting. The opportunity for specific nutritional interventions is encouraging.

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Authors and Affiliations

  1. Division of Metabolic and Cellular Medicine, School of Clinical Science, Duncan Building, UCD, University of Liverpool, Liverpool, L69 3GA, UK

    R. D. Griffiths, T. Bongers & A. McArdle

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  1. R. D. Griffiths
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  2. T. Bongers
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  3. A. McArdle
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Editors and Affiliations

  1. Health Sciences Center, Division Pulmonary & Critical Care Medicine, University of Colorado, E. Ninth Avenue 4200, 80262, Denver, CO, USA

    Edward Abraham MD

  2. Bloomsbury Institute of Intensive Care, Division Medicine, University College Hospital, Gower Street, WC1E 6BT, London, UK

    Mervyn Singer MD

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Griffiths, R.D., Bongers, T., McArdle, A. (2007). Skeletal Muscle. In: Abraham, E., Singer, M. (eds) Mechanisms of Sepsis-Induced Organ Dysfunction and Recovery. Update in Intensive Care and Emergency Medicine, vol 44. Springer, Berlin, Heidelberg . https://doi.org/10.1007/3-540-30328-6_31

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  • DOI: https://doi.org/10.1007/3-540-30328-6_31

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-540-30157-8

  • Online ISBN: 978-3-540-30328-2

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