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Metabolic Pathways

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Mechanisms of Sepsis-Induced Organ Dysfunction and Recovery

Part of the book series: Update in Intensive Care and Emergency Medicine ((UICMSOFT,volume 44))

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Conclusion

The understanding of sepsis-induced organ dysfunction has advanced considerably over the last few years. The interaction between signaling systems and metabolic pathways is a particularly ‘hot’ area of ongoing research. Energy production and the availability of substrates in the acute phase seem to have a crucial impact on the course of sepsis and on mortality and morbidity. Later on, during MOF, the same metabolic pathways determine outcome, but the mechanisms and clinical picture are different. Knowledge of these mechanisms is, therefore, necessary for optimal clinical practice.

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Author information

Authors and Affiliations

  1. Dept of Anesthesiology and Intensive Care Medicine K32, Karolinska University Hospital Huddinge, 14186, Stockholm, Sweden

    O. Rooyackers & J. Wernerman

Authors
  1. O. Rooyackers
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  2. J. Wernerman
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Editors and Affiliations

  1. Health Sciences Center, Division Pulmonary & Critical Care Medicine, University of Colorado, E. Ninth Avenue 4200, 80262, Denver, CO, USA

    Edward Abraham MD

  2. Bloomsbury Institute of Intensive Care, Division Medicine, University College Hospital, Gower Street, WC1E 6BT, London, UK

    Mervyn Singer MD

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© 2007 Springer-Verlag Berlin Heidelberg

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Rooyackers, O., Wernerman, J. (2007). Metabolic Pathways. In: Abraham, E., Singer, M. (eds) Mechanisms of Sepsis-Induced Organ Dysfunction and Recovery. Update in Intensive Care and Emergency Medicine, vol 44. Springer, Berlin, Heidelberg . https://doi.org/10.1007/3-540-30328-6_22

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  • DOI: https://doi.org/10.1007/3-540-30328-6_22

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-540-30157-8

  • Online ISBN: 978-3-540-30328-2

  • eBook Packages: MedicineMedicine (R0)

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