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The Role of the Endothelium

  • Conference paper
Mechanisms of Sepsis-Induced Organ Dysfunction and Recovery

Part of the book series: Update in Intensive Care and Emergency Medicine ((UICMSOFT,volume 44))

Conclusion

In summary, the endothelium is a spatially distributed cell layer that displays significant heterogeneity in both structure and function. Endothelial heterogeneity reflects the capacity of the endothelium to meet the diverse needs of the underlying tissues. The endothelium plays an important role in mediating the host response to infection. Not only do endothelial cells express pattern recognition receptors, but they also govern local blood flow and vectorial transport of cells, solutes, and fluids across the vascular wall. The normal response to infection involves activation of endothelial cells without dysfunction. In sepsis, the endothelial response becomes excessive, sustained, and/or disseminated, at which point the activation phenotype poses a liability to the host and may be characterized as dysfunctional. Important goals for the future are to develop reliable diagnostic assays for monitoring the health of the endothelium and to elucidate those components of the endothelial response that are maladaptive and amenable to therapeutic targeting.

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Authors and Affiliations

  1. Molecular Medicine, Beth Israel Deaconess Medical Center, RW-663 330 Brookline Avenue, Boston, MA, 02215, USA

    W. C. Aird

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Editors and Affiliations

  1. Health Sciences Center, Division Pulmonary & Critical Care Medicine, University of Colorado, E. Ninth Avenue 4200, 80262, Denver, CO, USA

    Edward Abraham MD

  2. Bloomsbury Institute of Intensive Care, Division Medicine, University College Hospital, Gower Street, WC1E 6BT, London, UK

    Mervyn Singer MD

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Aird, W.C. (2007). The Role of the Endothelium. In: Abraham, E., Singer, M. (eds) Mechanisms of Sepsis-Induced Organ Dysfunction and Recovery. Update in Intensive Care and Emergency Medicine, vol 44. Springer, Berlin, Heidelberg . https://doi.org/10.1007/3-540-30328-6_14

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  • DOI: https://doi.org/10.1007/3-540-30328-6_14

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