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Maligne Dünndarmtumoren

  • Chapter
Praxis der Viszeralchirurgie

Zusammenfassung

Maligne Dünndarmtumoren sind sehr selten und machen nur 1–3% aller malignen Tumoren des Gastrointestinaltrakts aus. Die Schwierigkeit der rechtzeitigen Diagnosestellung spiegelt sich in der erheblichen zeitlichen Latenz bis zur Diagnosestellung wider, welche konsekutiv in einer hohen Anzahl von lokal fortgeschrittenen Tumorstadien resultiert.

Therapie der Wahl ist beim Adenokarzinom des Dünndarms die radikale chirurgische Resektion. Lymphome des Dünndarms mit monolokulärem Befall (30% der Fälle) werden ebenfalls chirurgisch behandelt. Die Mehrzahl der Lymphome (70% der Fälle) präsentiert sich allerdings multilokulär oder mit positiven retroperitonealen Lymphknoten, diese sollten daher primär chemotherapeutisch behandelt werden.

Maligne Dünndarmtumoren stellen bezüglich Diagnosefindung und Therapie eine Herausforderung an jeden ärztlich tätigen Kollegen dar.

Im Falle unklarer abdomineller Beschwerden mit schon vorhandener Abklärung anderer wichtiger und häufiger vorkommender Erkrankungen ohne adäquate Diagnosestellung muss ein maligner Dünndarmtumor ins Kalkül gezogen werden.

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Internetadressen

  • http://www.merck.com/mrkshared/mmanual/section3/chapter34/34c.jsp

    Google Scholar 

  • http://www.oncolink.com/types/article.cfm?c=5&s=74&ss=778&id=9498

    Google Scholar 

  • http://www.cancerbarcup.org.uk/Cancertype/Bowelcolonrectum/Smallbowel/Smallbowelcancer

    Google Scholar 

  • http://www.krebsinfo.de/ki/empfehlung/gastro/760-19-Gross.pdf

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  • http://www.gastroresource.com/GITtextbook/En/Chapter7/7-24.htm

    Google Scholar 

Literatur

  • Aldini R, Montagnani M, Roda A, Hrelia S, Biagi PL, Roda E (1986) Intestinal absorption of bile acids in the rabbit: different transport rates in jejunum and ileum. Gastroenterology 110: 459–468

    Google Scholar 

  • Ashley SW, Wells jr S (1988) Tumors of the small intestine. Sem Oncol 15(2): 116–128

    CAS  Google Scholar 

  • Barclay THC, Schapira DV (1983) Malignant tumors of the small intestine. Cancer 51(5): 878–881

    CAS  PubMed  Google Scholar 

  • Brücher BLDM, Roder JD, Fink U, Stein HJ, Busch R, Siewert JR (1998) Prognostic factors in resected small bowel tumors. Dig Surg 15: 42–51

    PubMed  Google Scholar 

  • Brücher BLDM, Roder JD, Busch, R, Fink U, Stein H, Werner M, Siewert JR (2001) New aspects in prognostic factors in adenocarcinomas of the small bowel. Hepatogastroenterology 48(39): 727–732

    PubMed  Google Scholar 

  • Capello C, Heitz PU, Höfler H, Solcia E, Klöppel G (1994) Revised classification of neuroendocrine tumors of the lung, pancreas, gut. Digestion 55(Suppl 3): 11–23

    Google Scholar 

  • Carbone PP, Kaplan HS, Musshoff K, Smithers DW, Tubiana M (1971) Report of the committee on Hodgkin’s disease staging procedures. Cancer Res 31: 1860–1861

    CAS  PubMed  Google Scholar 

  • Cicarelli O, Welch JP, Kent GG (1987) Primary malignant tumors of the small bowel: the Hartford hospital experience, 1969–1983. Am J Surg 153: 350–354

    Google Scholar 

  • Coit DG (1993) Cancer of the small bowel/Chapter 29 in Cancer: Principles & practice of oncology, 4th edn. Lippincott, Philadelphia. pp 915–926

    Google Scholar 

  • Croom RD, Newsome JF (1975) Tumors of the small intestine. The American Surgeon 41: 160–167

    PubMed  Google Scholar 

  • Cunningham JD, Aleali R, Aleali M, Brower S, Aufses AHL (1997) Malignant small bowel neoplasms: histopathological determinants of recurrence and survival. Ann Surg 225(3): 300–306

    Article  CAS  PubMed  Google Scholar 

  • Darling RC, Welch CE (1959) Tumors of the small intestine. New Engl J Med 260(9): 397–408

    CAS  PubMed  Google Scholar 

  • Delcore R, Thomas JH, Forster J, Hermreck AS (1993) Improving resectability and survival in patients with primary duodenal carcinoma. Am J Surg 166: 626–631

    CAS  PubMed  Google Scholar 

  • De Mascarenhas-Saraiva MN, Da Silva Araujo Lopes LM (2003) Small bowel tumors diagnosed by wireless capsule endoscopy: report of five cases. Endoscopy 35(10): 865–868

    PubMed  Google Scholar 

  • Demetri GD, von Mehren M, Blanke CD et al. (2002) Efficiency and safety of imatinib mesylate in advanced gastrointestinal stromal tumors. N Engl J Med 347: 472–480

    Article  CAS  PubMed  Google Scholar 

  • Dragosics B, Bauer P, Radaskiewicz T (1985) Primary gastrointestinal non-hodgkin’s-lymphomas: a retrospective clinicopathological study of 150 cases. Cancer 55(5): 1060–1073

    CAS  PubMed  Google Scholar 

  • Feyrter F (1938) Über diffuse endokrine epitheliale Organe. Zentralbl Inn Med 5: 234

    Google Scholar 

  • Flierdt E van de, Frank T, Laubenbacher C, Fink U, Bauer R, Langhammer HR, Pabst W (1998) Klinische Relevanz der I-123/I-131-MIBG-Szintigraphie bei intestinalen Karzinoiden. Nuklearmedizin 37: 129–133

    PubMed  Google Scholar 

  • Freund H, Lavi A, Pfeffermann R, Durst AL (1978) Primary neoplasms of the small bowel. Am J Surg 135(6): 757–759

    Article  CAS  PubMed  Google Scholar 

  • Godwin JD (1975) Carcinoid tumors: an analysis of 2837 cases. Cancer 36(2): 560–569

    PubMed  Google Scholar 

  • Goel IP, Didolkar MS, Elias EG (1976) Primary malignant tumors of the small intestine. Surg Gynecol Obst 143: 717–719

    CAS  Google Scholar 

  • Gupta S (1982) Primary tumors of the small bowel: a clinicopathological study of 58 cases. J Surg Onc 20: 161–167

    CAS  Google Scholar 

  • Hara AK, Leighton JA, Sharma VK, Fleischer DE (2004) Small bowel: preliminary comparison of capsule endoscopy versus barium study and CT. Radiology 230(1): 260–265

    PubMed  Google Scholar 

  • Isaacson PG, Norton AJ (1994) Extranodal lymphomas. Churchill, Livingstone

    Google Scholar 

  • Kelm C, Padberg W, Zimmermann T, Hürtgen M, Buhr J (1994) Maligne Tumoren des Dünndarms. Zentralbl Chir 119: 639–644

    CAS  PubMed  Google Scholar 

  • Likely DS, Lisa JR, Stitch MH, Stein HD (1948) Primary malignant disease of the small bowel. Arch Int Med: 206–216

    Google Scholar 

  • Lowenfels AB (1973) Why are small bowel tumors so rare? Lancet: 24–25

    Google Scholar 

  • Manier JW (1985) Duodenal neoplasms. In: Berk JE (ed) Bockus gastroenterology, 4th edn. Saunders, Philadelphia, pp 1428–1438

    Google Scholar 

  • Martin GM (1986) Malignant tumors of the small intestine. Surg Clin North Am 6(4): 779–785

    Google Scholar 

  • Miles RM, Crawford D, Duras S (1978) The small bowel tumor problem: an assessment based on 20 year experience with 116 cases. Ann Surg 189(6): 732–740

    Google Scholar 

  • Mittal VK, Bodzin JH (1980) Primary malignant tumors of the small bowel. Am J Surg 140: 396–399

    Article  CAS  PubMed  Google Scholar 

  • Naef M, Bühlmann M, Baer HU (1999) Small bowel tumors: diagnosis, therapy and prognostic factors. Langenbeck’s Arch Surg 384: 176–180

    CAS  Google Scholar 

  • Ouriel K, Adams J (1984) Adenocarcinoma of the small intestine. Am J Surg 147: 66–71

    Article  CAS  PubMed  Google Scholar 

  • Peck JJ, Shields AB, Boyden AM, Dworkin LA, Nadal JW (1983) Carcinoid tumors of the ileum. Am J Surg 146: 124–132

    Article  CAS  PubMed  Google Scholar 

  • Rochlin DB, Longmire jr WP (1961) Primary tumors of the small intestine. Surgery 50(4): 586–592

    CAS  PubMed  Google Scholar 

  • Ross RK, Hartnett NM, Bernstein L, Henderson BE (1991) Epidemiology of adenocarcinomas of the small intestine: is bile a small bowel carcinogen? Br J Cancer 63: 143–145

    CAS  PubMed  Google Scholar 

  • Singer S, Rubin BP, Lux ML et al. (2002) Prognostic value of KIT mutation type, mitotic activity and histologic subtype in gastrointestinal stromal tumors. J Clin Oncol 20: 2898–3905

    Article  Google Scholar 

  • Statistisches Bundesamt Wiesbaden (1996)

    Google Scholar 

  • UICC (2002) Sobin L, Wittekind C (Hrsg) TNM-Klassifikation maligner Tumoren, 6. Aufl. Springer, Berlin Heidelberg New York Tokio

    Google Scholar 

  • WHO (1989) Jass J, Sobin L (eds) International histological classification of tumors. Histological typing of intestinal tumors. Springer, Berlin Heidelberg New York Tokyo

    Google Scholar 

  • Zeitels J, Naunheim K, Kaplan EL, Strauss F (1982) Carcinoid tumors: a 37 year experience. Arch Surg 117: 732–737

    CAS  PubMed  Google Scholar 

  • Zollinger RM, Sternfeld WC, Schreiber H (1986) Primary neoplasms of the small intestine. Am J Surg 151: 654–658

    Article  PubMed  Google Scholar 

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Authors
  1. B. L. D. M. Brücher
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Editors and Affiliations

  1. Chirurgische Klinik und Poliklinik, Technische Universität München Klinikum rechts der Isar, Ismaninger Str. 22, 81657, München, Germany

    Jörg Rüdiger Siewert

  2. Zentrum für Operative Medizin I, Klinikum der Philipps-Universität, Baldinger Straße, 35043, Marburg, Germany

    Matthias Rothmund

  3. Medizinische Fakultät der RWTH, Universitätsklinik und Poliklinik, Pauwelsstr. 30, 52057, Aachen, Germany

    Volker Schumpelick

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© 2006 Springer Medizin Verlag Heidelberg

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Brücher, B.L.D.M. (2006). Maligne Dünndarmtumoren. In: Siewert, J.R., Rothmund, M., Schumpelick, V. (eds) Praxis der Viszeralchirurgie. Springer, Berlin, Heidelberg. https://doi.org/10.1007/3-540-30036-8_45

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  • DOI: https://doi.org/10.1007/3-540-30036-8_45

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-540-21914-9

  • Online ISBN: 978-3-540-30036-6

  • eBook Packages: Medicine (German Language)

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