Zusammenfassung
Bei der Immun- und der Gentherapie handelt es sich um neuartige, noch experimentelle Therapieformen. Schwerpunkte der Forschung sind z. Z. noch die Weiterentwicklung der Methoden und die Charakterisierung geeigneter molekularer Zielstrukturen. Daher sind der endgültige Stellenwert dieser Verfahren und ihre jeweiligen Anwendungsbereiche gegenwärtig noch nicht abzusehen. Nachfolgend sollen exemplarisch immun- und gentherapeutische Strategien zur Behandlung maligner Tumoren dargestellt werden.
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Literatur
Allay JA, Persons DA, Galipeau J, Riberdy JM, Ashmun RA, Blakley RL, Sorrentino BP (1998) In vivo selection of retrovirally transduced hematopoietic stem cells. Nat Med 4: 1136–1143
Åman P (1999) Fusion genes in solid tumors. Sem Cancer Biol 9: 303–318
Baselga J, Tripathy D, Mendelsohn J et al. (1996) Phase II study of weekly intravenous recombinant humanized anti-p185HER2 monoclonal antibody in patients with HER2/neu-overexpressing metastatic breast cancer. J Clin Oncol 14: 737–744
Bernhard H, Meyerzum Büschenfelde C, Peschel C (2001) Adoptiver Transfer von tumorreaktiven T-Zellen. Onkologe 11: 1196–1201
Blattman JN, Greenberg PD (2004) Cancer immunotherapy: a treatment for the masses. Science 305: 200–205
Bonini C, Ferrari G, Verzeletti S et al. (1997) HSV-TK gene transfer into donor lymphocytes for control of allogeneic graft-versus-leukemia. Science 276: 1719–1724
Bouvet M, Ellis LM, Nishizaki M et al. (1998) Adenovirus-mediated wild-type p53 gene transfer down-regulates vascular endothelial growth factor expression and inhibits angiogenesis in human colon cancer. Cancer Res. 58: 2288–2292
Brenner MK, DR Rill, RC Moen, RA Krance, J Mirro Jr, WF Anderson, JN Ihle (1993) Gene-marking to trace origin of relapse after autologous bone-marrow transplantation. Lancet 341: 85–86
Clayman GL, el-Naggar AK, Lippman SM et al. (1998) Adenovirus-mediated p53 gene transfer in patients with advanced recurrent head and neck squamous cell carcinoma. J Clin Oncol 16: 2221–2232
Deisseroth AB, Zu Z, Claxton D et al. (1994) Genetic marking shows that Ph+ cells present in autologous transplants of chronic myelogenous leukemia (CML) contribute to relapse after autologous bone marrow in CML. Blood 83: 3068–3076
Donk van de NW, de Weerdt O, Veth G et al. (2004) G3139, a Bcl-2 antisense oligodeoxynucleotide, induces clinical responses in VAD refractory myeloma. Leukemia 18: 1078–1084
Dunn GP, Old LJ, Schreiber RD (2004) The immunobiology of cancer immunosurveillance and immunoediting. Immunity 21: 137–148
Finn OJ (2003) Cancer vaccines: between the idea and the reality. Nat Rev Immunol 3: 630–641
Freytag SO, Khil M, Stricker H et al. (2002) Phase I study of replication-competent adenovirus-mediated double suicide gene therapy for the treatment of locally recurrent prostate cancer. Cancer Res 62: 4968–4976
Hacein-Bey-Abina S, Von Kalle C, Schmidt M et al. (2002) LMO2-associated clonal T cell proliferation in two patients after gene therapy for SCID-X1. Science 302: 415–419
Heise C, Sampson-Johannes A, Williams A, McCormick F, Von Hoff DD, Kirn DH (1997) ONYX-015, an E1B gene-attenuated adenovirus, causes tumor-specific cytolysis and antitumoral efficacy that can be augmented by standard chemotherapeutic agents. Nat Med 3: 639–645
Holmgren L, Jackson G, Arbiser J (1998) p53 induces angiogenesis-restricted dormancy in a mouse fibrosarcoma. Oncogene 17: 819–824
Khuri FR, Nemunaitis J, Ganly I et al. (2000) A controlled trial of intratumoral ONYX-015, a selectively-replicating adenovirus, in combination with cisplatin and 5-fluorouracil in patients with recurrent head and neck cancer. Nat Med 6: 879–885
Licht T, Hafkemeyer P (1999) Aktuelle Aspekte der somatischen Gentherapie. Dtsch Med Wochenschr 124: 700–706
Licht T, Haskins M, Henthorn P et al. (2002) Drug selection with paclitaxel restores expression of linked IL-2 receptor gamma-chain and multidrug resistance (MDR1) transgenes in canine bone marrow. Proc Natl Acad Sci USA. 99: 3123–3128
McLaughlin P, Grillo-Lopez A, Link B et al. (1998) Rituximab chimeric anti-CD20 monoclonal antibody therapy for relapsed indolent lymphoma: Half of patients respond to a four-dose treatment program. J Clin Oncol 16: 2825–2833
Mickisch GH, Licht T, Merlino GT, Gottesman MM, Pastan I (1991) Chemotherapy and chemosensitization of transgenic mice which express the human multidrug resistance gene in bone marrow: Efficacy, potency and toxicity. Cancer Res 51: 5417–5424
Moscow JA, Huang H, Carter C et al. (1999) Engraftment of MDR1 and NeoR gene-transduced hematopoietic cells after breast cancer chemotherapy. Blood 94: 52–61
Pandha HS, Martin LA, Rigg A, Hurst HC, Stamp GW, Sikora K, Lemoine NR (1999) Genetic prodrug activation therapy for breast cancer: A Phase I clinical trial of erbB-2-directed suicide gene expression. J Clin Oncol 17: 2180–2189
Rabbits T (1994) Chromosomal translocations in human cancer. Nature 372: 143–149
Rainov NG (2000) A phase III clinical evaluation of herpes simplex virus type 1 thymidine kinase and ganciclovir gene therapy as an adjuvant to surgical resection and radiation in adults with previously untreated glioblastoma multiforme. Hum Gene Ther 11: 2389–2401
Ram Z, Culver KW, Oshiro EM et al. (1997) Therapy of malignant brain tumors by intratumoral implantation of retroviral vector-producing cells. Nat Med 3: 1354–136
Rehwald, U., Diehl, V., Engert, A (2001) Antikörper, Immuntoxine, Radioimmunkonjugate. Onkologe 11: 1206–1219
Rooney CM, Smith CA, Ng CY et al. (1998) Infusion of cytotoxic T cells for the prevention and treatment of Epstein-Barr virus-induced lymphoma in allogeneic transplant recipients. Blood 92: 1549–1555
Roth JA, Nguyen D, Lawrence DD et al. (1996) Retrovirus-mediated wildtype p53 gene transfer to tumors of patients with lung cancer. Nat Med 2: 985–991
Saltz LB, Meropol NJ, Loehrer PJ Sr, Needle MN, Kopit J, Mayer RJ (2004) Phase II trial of cetuximab in patients with refractory colorectal cancer that expresses the epidermal growth factor receptor. J Clin Oncol 22: 1201–1208
Schuler M, Rochlitz C, Horowitz JA et al. (1998) A phase I study of adenovirus-mediated wild-type p53 gene transfer in patients with advanced non-small cell lung cancer. Hum Gene Ther 9: 2075–2082
Schuler G, Schuler-Thurner B, Steinman RM (2003) The use of dendritic cells in cancer immunotherapy. Curr Opin Immunol 15: 138–147
Sosman JA, Unger JM, Liu PY et al., Southwest Oncology Group (2002) Adjuvant immunotherapy of resected, intermediate-thickness, node-negative melanoma with an allogeneic tumor vaccine: impact of HLA class I antigen expression on outcome. J Clin Oncol 15: 2067–2075
Steiner MS, Anthony CT, Lu Y, Holt JT (1998) Antisense c-myc retroviral vector suppresses established human prostate cancer. Hum Gene Ther 9: 747–755
Suto R, Tominaga K, Mizuguchi H et al. (2004) Dominant-negative mutant of c-Jun gene transfer: a novel therapeutic strategy for colorectal cancer. Gene Ther 11: 187–193
Swisher SG, Roth JA, Nemunaitis J et al. (1999) Adenovirus-mediated p53 gene transfer in advanced non-small-cell lung cancer. J Natl Cancer Inst 91: 763–771
Tanaka K, Iwakuma T, Harimaya K, Sato H, Iwamoto Y (1997) EWS-Fli1 antisense oligodeoxynucleotide inhibits proliferation of human Ewing’s sarcoma and primitive neuroectodermal tumor cells. J Clin Invest 99: 239–247
Webb A, Cunningham D, Cotter F et al. (1997) BCL-2 antisense therapy in patients with non-Hodgkin lymphoma. Lancet 349: 1137–1141
Wei J, Blum S, Unger M et al. (2004) Embryonic endothelial progenitor cells armed with a suicide gene target hypoxic lung metastases after intravenous delivery. Cancer Cell 477–488
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Bernhard, H., Licht, T., Peschel, C. (2006). Immun- und Gentherapie bei malignen Erkrankungen. In: Siewert, J.R., Rothmund, M., Schumpelick, V. (eds) Praxis der Viszeralchirurgie. Springer, Berlin, Heidelberg. https://doi.org/10.1007/3-540-30036-8_25
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