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Proton Therapy

  • Harald Paganetti
  • Thomas Bortfeld
Part of the Medical Radiology book series (MEDRAD)

Keywords

Proton Beam Radiat Oncol Biol Phys Proton Therapy Normal Tissue Complication Probability Proton Beam Therapy 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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References

  1. Archambeau JO, Slater JD, Slater JM, Tangeman R (1992) Role for proton beam irradiation in treatment of pediatric CNS malignancies. Int J Radiat Oncol Biol Phys 22:287–294PubMedGoogle Scholar
  2. Benk V, Liebsch NJ, Munzenrider JE, Efird J, McManus P, Suit H (1995) Base of skull and cervical spine chordomas in children treated by high-dose irradiation. Int J Radiat Oncol Biol Phys 31:577–558PubMedCrossRefGoogle Scholar
  3. Blosser H, Bailey J, Burleigh R, Johnson D, Kashy E, Kuo T, Marti F, Vincent J, Zeller A, Blosser E, Blosser G, Maughan R, Power W, Wagner J (1989) Superconducting cyclotron for medical applications. IEEE Trans Magn 25:1746–1754CrossRefGoogle Scholar
  4. Bortfeld T, Jokivarsi K, Goitein M, Kung J, Jiang SB (2002) Effects of intra-fraction motion on IMRT dose delivery: statistical analysis and simulation. Phys Med Biol 47:2303–2320CrossRefGoogle Scholar
  5. Bussiere MR, Adams JA (2003) Treatment planning for conformal proton radiation therapy. Technol Cancer Res Treat 2:389–399PubMedGoogle Scholar
  6. Chu WT, Ludewigt BA, Renner TR (1993) Instrumentation for treatment of cancer using proton and light-ion beams. Rev Sci Instrum 64:2055–2122Google Scholar
  7. Coutrakon G, Slater JM, Ghebremedhin A (1999) Design considerations for medical proton accelerators. Proc 1999 Particle Accelerator Conference, New York, pp 11–15Google Scholar
  8. Cozzi L, Fogliata A, Lomax A, Bolsi A (2001) A treatment planning comparison of 3D conformal therapy, intensity modulated photon therapy and proton therapy for treatment of advanced head and neck tumours. Radiother Oncol 61:287–297PubMedCrossRefGoogle Scholar
  9. Deasy JO, Shepard DM, Mackie TR (1997) Distal edge tracking: a proposed delivery method for conformal proton therapy using intensity modulation. In: Leavitt DD, Starkschall G (eds) XIIth International Conference on the Use of Computers in Radiation Therapy. Medical Physics Publishing, Madison, Wisconsin, pp 406–409Google Scholar
  10. Delaney TF, Smith AR, Lomax A, Adams J, Loeffler JS (2003) Proton beam radiation therapy. Cancer Prin Pract Oncol 17:1–10Google Scholar
  11. Flanz J, Durlacher S, Goitein M, Levine A, Reardon P, Smith A (1995) Overview of the MGH-Northeast Proton Therapy Center plans and progress. Nucl Instrum Methods Phys Res B 99:830–834CrossRefGoogle Scholar
  12. Fuss M, Hug EB, Schaefer RA, Nevinny-Stickel M, Miller DW, Slater JM, Slater JD (1999) Proton radiation therapy (PRT) for pediatric optic pathway gliomas: comparison with 3D planned conventional photons and a standard photon technique. Int J Radiat Oncol Biol Phys 45:1117–1126PubMedGoogle Scholar
  13. Fuss M, Poljanc K, Miller DW, Archambeau JO, Slater JM, Slater JD, Hug EB (2000) Normal tissue complication probability (NTCP) calculations as a means to compare proton and photon plans and evaluation of clinical appropriateness of calculated values. Int J Cancer 90:351–358PubMedCrossRefGoogle Scholar
  14. Goitein M, Jermann M (2003) The relative costs of proton and X-ray radiation therapy. Clin Oncol 15:S37–S50CrossRefGoogle Scholar
  15. Goitein M, Miller T (1983) Planning proton therapy of the eye. Med Phys 10:275–283PubMedGoogle Scholar
  16. Goodhead DT (1990) Radiation effects in living cells. Can J Phys 68:872–886Google Scholar
  17. Grusell E, Montelius A, Brahme A, Rikner G, Russell K (1994) A general solution to charged particle beam flattening using an optimized dual-scattering-foil technique, with application to proton therapy beams. Phys Med Biol 39:2201–2216PubMedCrossRefGoogle Scholar
  18. Hara I, Murakami M, Kagawa K, Sugimura K, Kamidono S, Hishikawa Y, Abe M (2004) Experience with conformal proton therapy for early prostate cancer. Am J Clin Oncol 27:323–327PubMedGoogle Scholar
  19. Harsh G, Loeffler JS, Thornton A, Smith A, Bussiere M, Chapman PH (1999) Stereotactic proton radiosurgery. Neurosurg Clin North Am 10:243–256Google Scholar
  20. Hong L, Goitein M, Bucciolini M, Comiskey R, Gottschalk B, Rosenthal S, Serago C, Urie M (1996) A pencil beam algorithm for proton dose calculations. Phys Med Biol 41:1305–1330PubMedCrossRefGoogle Scholar
  21. Hug EB, Slater JD (1999) Proton radiation therapy for pediatric malignancies: status report. Strahlenther Onkol 175(Suppl) 2:89–91PubMedGoogle Scholar
  22. Hug EB, Fitzek MM, Liebsch NJ, Munzenrider JE (1995) Locally challenging osteo-and chondrogenic tumors of the axial skeleton: results of combined proton and photon radiation therapy using three-dimensional treatment planning. Int J Radiat Oncol Biol Phys 31:467–476PubMedCrossRefGoogle Scholar
  23. Hug EB, Devries A, Thornton AF, Munzenrider JE, Pardo FS, Hedley-Whyte ET, Bussiere MR, Ojemann R (2000) Management of atypical and malignant meningiomas: role of high-dose, 3D-conformal radiation therapy. J Neuro-Oncol 48:151–160CrossRefGoogle Scholar
  24. Isacsson U, Montelius A, Jung B, Glimelius B (1996) Comparative treatment planning between proton and X-ray therapy in locally advanced rectal cancer. Radiother Oncol 41:263–272PubMedCrossRefGoogle Scholar
  25. Isacsson U, Hagberg H, Johansson K-A, Montelius A, Jung B, Glimelius B (1997) Potential advantages of protons over conventional radiation beams for paraspinal tumours. Radiother Oncol 45:63–70PubMedCrossRefGoogle Scholar
  26. Isacsson U, Lennernäs B, Grusell E, Jung B, Montelius A, Glimelius B (1998) Comparative treatment planning between proton and X-ray therapy in esophageal cancer. Int J Radiat Oncol Biol Phys 41:441–450PubMedCrossRefGoogle Scholar
  27. Jiang H, Paganetti H (2004) Adaptation of GEANT4 to Monte Carlo dose calculations based on CT data. Med Phys 31:2811–2818PubMedCrossRefGoogle Scholar
  28. Kanai T, Kawachi K, Kumamoto Y, Ogawa H, Yamada T, Matsuzawa H, Inada T (1980) Spot scanning system for proton radiotherapy. Med Phys 7:365–369PubMedCrossRefGoogle Scholar
  29. Koehler AM, Schneider RJ, Sisterson JM (1975) Range modulators for protons and heavy ions. Nucl Instrum Methods 131:437–440CrossRefGoogle Scholar
  30. Koehler AM, Schneider RJ, Sisterson JM (1977) Flattening of proton dose distributions for large-field radiotherapy. Med Phys 4:297–301PubMedCrossRefGoogle Scholar
  31. Kraft G (2000) Tumortherapy with ion beams. Nucl Instrum Methods Phys Res A 454:1–10CrossRefGoogle Scholar
  32. Laitano RF, Rosetti M, Frisoni M (1996) Effects of nuclear interactions on energy and stopping power in proton beam dosimetry. Nucl Instrum Methods A 376:466–476CrossRefGoogle Scholar
  33. Lee M, Wynne C, Webb S, Nahum AE, Dearnaley D (1994) A comparison of proton and megavoltage X-ray treatment planning for prostate cancer. Radiother Oncol 33:239–253PubMedCrossRefGoogle Scholar
  34. Levin CV (1992) Potential for gain in the use of proton beam boost to the para-aortic lymph nodes in carcinoma of the cervix. Int J Radiat Oncol Biol Phys 22:355–359PubMedGoogle Scholar
  35. Lin R, Hug EB, Schaefer RA, Miller DW, Slater JM, Slater JD (2000) Conformal proton radiation therapy of the posterior fossa: a study comparing protons with three-dimensional planned photons in limiting dose to auditory structures. Int J Radiat Oncol Biol Phys 48:1219–1226PubMedGoogle Scholar
  36. Lomax A (1999) Intensity modulation methods for proton radiotherapy. Phys Med Biol 44:185–205PubMedCrossRefGoogle Scholar
  37. Lomax AJ, Bortfeld T, Goitein G, Debus J, Dykstra C, Tercier P-A, Coucke PA, Mirimanoff RO (1999) A treatment planning inter-comparison of proton and intensity modulated photon radiotherapy. Radiother Oncol 51:257–271PubMedCrossRefGoogle Scholar
  38. Lomax AJ, Boehringer T, Coray A, Egger E, Goitein G, Grossmann M, Juelke P, Lin S, Pedroni E, Rohrer B, Roser W, Rossi B, Siegenthaler B, Stadelmann O, Stauble H, Vetter C, Wisser L (2001) Intensity modulated proton therapy: a clinical example. Med Phys 28:317–324PubMedCrossRefGoogle Scholar
  39. Lomax AJ, Cella L, Weber D, Kurtz JM, Miralbell R (2003a) Potential role of intensity-modulated photons and protons in the treatment of the breast and regional nodes. Int J Radiat Oncol Biol Phys 55:785–792PubMedGoogle Scholar
  40. Lomax AJ, Goitein M, Adams J (2003b) Intensity modulation in radiotherapy: photons versus protons in the paranasal sinus. Radiother Oncol 66:11–18PubMedCrossRefGoogle Scholar
  41. McAllister B, Archambeau JO, Nguyen MC, Slater JD, Loredo L, Schulte R, Alvarez O, Bedros AA, Kaleita T, Moyers M, Miller D, Slater JM (1997) Proton therapy for pediatric cranial tumors: preliminary report on treatment and disease-related morbidities. Int J Radiat Oncol Biol Phys 39:455–460PubMedCrossRefGoogle Scholar
  42. Medin J, Andreo P (1997) Monte Carlo calculated stoppingpower ratios, water/air, for clinical proton dosimetry (50–250 MeV). Phys Med Biol 42:89–105PubMedCrossRefGoogle Scholar
  43. Minohara S, Kanai T, Endo M, Noda K, Kanazawa M (2000) Respiratory gated irradiation system for heavy-ion radiotherapy. Int J Radiat Oncol Biol Phys 47:1097–1103PubMedCrossRefGoogle Scholar
  44. Miralbell R, Crowell C, Suit HD (1992) Potential improvement of three dimension treatment planning and proton therapy in the outcome of maxillary sinus cancer. Int J Radiat Oncol Biol Phys 22:305–310PubMedGoogle Scholar
  45. Miralbell R, Lomax A, Russo M (1997) Potential role of proton therapy in the treatment of pediatric medulloblastoma/ primitive neuro-ectodermal tumors: spinal theca irradiation. Int J Radiat Oncol Biol Phys 38:805–811PubMedGoogle Scholar
  46. Moyers MF, Miller DW, Bush DA, Slater JD (2001) Methodologies and tools for proton beam design for lung tumors. Int J Radiat Oncol Biol Phys 49:1429–1438PubMedCrossRefGoogle Scholar
  47. Niemierko A, Urie M, Goitein M (1992) Optimization of 3D radiation therapy with both physical and biological end points and constraints. Int J Radiat Oncol Biol Phys 23:99–108PubMedGoogle Scholar
  48. Nowakowski VA, Castro JR, Petti PL, Collier JM, Daftari I, Ahn D, Gauger G, Gutin P, Linstadt DE, Phillips TL (1992) Charged particle radiotherapy of paraspinal tumors. Int J Radiat Oncol Biol Phys 22:295–303PubMedGoogle Scholar
  49. Oelfke U, Bortfeld T (2001) Inverse planning for photon and proton beams. Med Dosim 26:113–124PubMedCrossRefGoogle Scholar
  50. Paganetti H (1998) Calculation of the spatial variation of relative biological effectiveness in a therapeutic proton field for eye treatment. Phys Med Biol 43:2147–2157PubMedCrossRefGoogle Scholar
  51. Paganetti H (2002) Nuclear interactions in proton therapy: dose and relative biological effect distributions originating from primary and secondary particles. Phys Med Biol 47:747–764PubMedCrossRefGoogle Scholar
  52. Paganetti H (2003) Significance and implementation of RBE variations in proton beam therapy. Technol Cancer Res Treatment 2:413–426Google Scholar
  53. Paganetti H, Goitein M (2000) Radiobiological significance of beam line dependent proton energy distributions in a spread-out Bragg peak. Med Phys 27:1119–1126PubMedCrossRefGoogle Scholar
  54. Paganetti H, Goitein M (2001) Biophysical modeling of proton radiation effects based on amorphous track models. Int J Radiat Biol 77:911–928PubMedCrossRefGoogle Scholar
  55. Paganetti H, Olko P, Kobus H, Becker R, Schmitz T, Waligorski MPR, Filges D, Mueller-Gaertner HW (1997) Calculation of RBE for proton beams using biological weighting functions. Int J Radiat Oncol Biol Phys 37:719–729PubMedCrossRefGoogle Scholar
  56. Paganetti H, Niemierko A, Ancukiewicz M, Gerweck LE, Loeffler JS, Goitein M, Suit HD (2002) Relative biological effectiveness (RBE) values for proton beam therapy. Int J Radiat Oncol Biol Phys 53:407–421PubMedCrossRefGoogle Scholar
  57. Paganetti H, Jiang H, Adams JA, Chen GT, Rietzel E (2004a) Monte Carlo simulations with time-dependent geometries to investigate organ motion with high temporal resolution. Int J Radiat Oncol Biol Phys 60:942–950PubMedCrossRefGoogle Scholar
  58. Paganetti H, Jiang H, Lee S-Y, Kooy H (2004b) Accurate Monte Carlo for nozzle design, commissioning, and quality assurance in proton therapy. Med Phys 31:2107–2118PubMedCrossRefGoogle Scholar
  59. Pawlicki T, Ma C-MC (2001) Monte Carlo simulation for MLC-based intensity-modulated radiotherapy. Med Dosim 26:157–168PubMedCrossRefGoogle Scholar
  60. Pedroni E, Bacher R, Blattmann H, Boehringer T, Coray A, Lomax A, Lin S, Munkel G, Scheib S, Schneider U, Tourovsky A (1995) The 200-MeV proton therapy project at the Paul Scherrer Institute: conceptual design and practical realization. Med Phys 22:37–53PubMedCrossRefGoogle Scholar
  61. Phillips MH, Pedroni E, Blattmann H, Boehringer T, Coray A, Scheib S (1992) Effects of respiratory motion on dose uniformity with a charged particle scanning method. Phys Med Biol 37:223–234PubMedCrossRefGoogle Scholar
  62. Phillips BL, Jiroutek MR, Tracton G, Elfervig M, Muller KE, Chaney EL (2002) Thresholds for human detection of patient setup errors in digitally reconstructed portal images of prostate fields. Int J Radiat Oncol Biol Phys 54:270–277PubMedCrossRefGoogle Scholar
  63. Robertson JB, Williams JR, Schmidt RA, Little JB, Flynn DF, Suit HD (1975) Radiobiological studies of a high-energy modulated proton beam utilizing cultured mammalian cells. Cancer 35:1664–1677PubMedGoogle Scholar
  64. Rosenberg AE, Nielsen GP, Keel SB, Renard LG, Fitzek MM, Munzenrider JE, Liebsch NJ (1999) Chondrosarcoma of the base of the skull: a clinicopathologic study of 200 cases with emphasis on its distinction from chordoma. Am J Surg Pathol 23:1370–1378PubMedCrossRefGoogle Scholar
  65. Shioyama Y, Tokuuye K, Okumura T, Kagei K, Sugahara S, Ohara K, Akine Y, Ishikawa S, Satoh H, Sekizawa K (2003) Clinical evaluation of proton radiotherapy for non-smallcell lung cancer. Int J Radiat Oncol Biol Phys 56:7–13PubMedCrossRefGoogle Scholar
  66. Sisterson JM (2004) Particles Newsletter. http://ptcog.mgh. harvard.eduGoogle Scholar
  67. Sisterson JM, Urie MM, Koehler AM, Goitein M (1989) Distal penetration of proton beams: the effects of air gaps between compensating bolus and patient. Phys Med Biol 34:1309–1315PubMedCrossRefGoogle Scholar
  68. Slater JD, Slater JM, Wahlen S (1992a) The potential for proton beam therapy in locally advanced carcinoma of the cervix. Int J Radiat Oncol Biol Phys 22:343–347PubMedGoogle Scholar
  69. Slater JM, Slater JD, Archambeau JO (1992b) Carcinoma of the tonsillar region: potential for use of proton beam therapy. Int J Radiat Oncol Biol Phys 22:311–319PubMedGoogle Scholar
  70. Slater JD, Rossi CJJ, Yonemoto LT, Bush DA, Jabola BR, Levy RP, Grove RI, Preston W, Slater JM (2004) Proton therapy for prostate cancer: the initial Loma Linda University experience. Int J Radiat Oncol Biol Phys 59:348–352PubMedCrossRefGoogle Scholar
  71. Smit BM (1992) Prospects for proton therapy in carcinoma of the cervix. Int J Radiat Oncol Biol Phys 22:349–353PubMedGoogle Scholar
  72. Tatsuzaki H, Urie MM, Linggood R (1992a) Comparative treatment planning: proton vs X-ray beams against glioblastoma multiforme. Int J Radiat Oncol Biol Phys 22:265–273PubMedGoogle Scholar
  73. Tatsuzaki H, Urie MM, Willett CG (1992b) 3-D comparative study of proton vs X-ray radiation therapy for rectal cancer. Int J Radiat Oncol Biol Phys 22:369–374PubMedGoogle Scholar
  74. Terahara A, Niemierko A, Goitein M, Finkelstein D, Hug E, Liebsch N, O’Farrell D, Lyons S, Munzenrider J (1999) Analysis of the relationship between tumor dose inhomogeneity and local control in patients with skull base chordoma. Int J Radiat Oncol Biol Phys 45:351–358PubMedCrossRefGoogle Scholar
  75. Thornton A, Fitzek M, Varvares M, Adams J, Rosenthal S, Pollock S, Jackson M, Pilch B, Joseph M (1998) Accelerated hyperfractionated proton/photon irradiation for advanced paranasal sinus cancer. Results of a perspective phase I-II study. Int J Radiat Oncol Biol Phys 42 (Suppl):222Google Scholar
  76. Tobias CA, Lawrence JH, Born JL, McCombs R, Roberts JE, Anger HO, Low-Beer BVA, Huggins C (1958) Pituitary irradiation with high energy proton beams: a preliminary report. Cancer Res 18:121–134PubMedGoogle Scholar
  77. Trofimov A, Bortfeld T (2003) Optimization of beam parameters and treatment planning for intensity modulated proton therapy. Technol Cancer Res Treatment 2:437–444Google Scholar
  78. Wambersie A, Gregoire V, Brucher J-M (1992) Potential clinical gain of proton (and heavy ion) beams for brain tumors in children. Int J Radiat Oncol Biol Phys 22:275–286PubMedGoogle Scholar
  79. Weber DC, Trofimov AV, Delaney TF, Bortfeld T (2004) A treatment plan comparison of intensity modulated photon and proton therapy for paraspinal sarcomas. Int J Radiat Oncol Biol Phys 58:1596–1606PubMedCrossRefGoogle Scholar
  80. Wenkel E, Thornton AF, Finkelstein D, Adams J, Lyons S, Monte S de la, Ojeman RG, Munzenrider JE (2000) Benign meningioma: partially resected, biopsied, and recurrent intracranial tumors treated with combined proton and photon radiotherapy. Int J Radiat Oncol Biol Phys 48:1363–1370PubMedCrossRefGoogle Scholar
  81. Wilkens JJ, Oelfke U (2004) A phenomenological model for the relative biological effectiveness in therapeutic proton beams. Phys Med Biol 49:2811–2825PubMedCrossRefGoogle Scholar
  82. Wilson RR (1946) Radiological use of fast protons. Radiology 47:487–491Google Scholar
  83. Wouters BG, Lam GKY, Oelfke U, Gardey K, Durand RE, Skarsgard LD (1996) RBE Measurement on the 70 MeV Proton Beam at TRIUMF using V79 cells and the high precision cell sorter assay. Radiat Res 146:159–170PubMedGoogle Scholar
  84. Yeboah C, Sandison GA (2002) Optimized treatment planning for prostate cancer comparing IMPT, VHEET and 15 mV IMXT. Phys Med Biol 47:2247–2261PubMedGoogle Scholar

Copyright information

© Springer-Verlag Berlin Heidelberg 2006

Authors and Affiliations

  • Harald Paganetti
    • 1
  • Thomas Bortfeld
    • 1
  1. 1.Massachusetts General HospitalHarvard Medical SchoolBostonUSA

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