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Extracranial Stereotactic Radiation Therapy

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New Technologies in Radiation Oncology

Part of the book series: Medical Radiology ((Med Radiol Radiat Oncol))

22.5 Conclusion

Stereotactic radiation treatment of extracranial targets shows promising initial results. The techniques are getting increasingly more specialized, especially in the treatment of small lung tumors; however, many questions remain unanswered. More experimental work and clinical trials are underway which should answer these question and should strengthen this promising approach.

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References

  • Blomgren H, Lax I, Näslund I et al. (1995) Stereotactic high dose fraction radiation therapy of extracranial tumors using an accelerator. Acta Oncol 34:861–870

    PubMed  CAS  Google Scholar 

  • Blomgren H, Lax I, Göranson H et al. (1998) Radiosurgery for tumors in the body: clinical experience using a new method. J Radiosurg 1:63–74

    Google Scholar 

  • Chang SD, Main W, Martin DP et al. (2003) An analysis of the accuracy of the CyberKnife: a robotic frameless stereotactic radiosurgical system. Neurosurgery 52:140–147

    PubMed  Google Scholar 

  • Chen JC, O’Day S, Morton D et al. (1999) Stereotactic radiosurgery in the treatment of metastatic disease to the brain. Stereotact Funct Neurosurg 73:60–63

    Article  PubMed  CAS  Google Scholar 

  • Dawson LA, Brock KK, Kazanjian S et al. (2001) The reproducibility of organ position using active breathing control (ABC) during liver radiotherapy. Int J Radiat Oncol Biol Phys 51:1410–1421

    PubMed  CAS  Google Scholar 

  • Dienemann H, Hof H, Debus J et al. (2004) Lungenmetastasen. Onkologe 10:458–473

    Article  Google Scholar 

  • Dosoretz DE, Galmarini D, Rubenstein JH et al. (1993) Local control in medically inoperable lung cancer: an analysis of its importance in outcome and factors determining the probability of tumor eradication. Int J Radiat Oncol Biol Phys 27:507–516

    PubMed  CAS  Google Scholar 

  • Fuss M, Salter BJ, Rassiah P et al. (2004) Repositioning accuracy of a commercially available double-vacuum whole body immobilization system for stereotactic body radiation therapy. Technol Cancer Res Treat 3:59–67

    PubMed  Google Scholar 

  • Gerszten PC, Ozhasoglu C, Burton SA et al. (2004) CyberKnife frameless stereotactic radiosurgery for spinal lesions: clinical experience in 125 cases. Neurosurgery 55:89–99

    PubMed  Google Scholar 

  • Hamilton AJ, Lulu BA (1995) A prototype device for linear accelerator-based extracranial radiosurgery. Acta Neurochir Suppl (Wien) 63:40–43

    CAS  Google Scholar 

  • Hamilton AJ, Lulu BA, Fosmire A et al. (1995) Preliminary clinical experience with linear accelerator-based spinal stereotactic radiosurgery. Neurosurgery 36:311–319

    PubMed  CAS  Google Scholar 

  • Hamilton AJ, Lulu BA, Fosmire H et al. (1996) LINAC-based spinal stereotactic radiosurgery. Stereotact Funct Neurosurg 66:1–9

    PubMed  CAS  Google Scholar 

  • Hanley J, Debois MM, Mah D et al. (1999a) Deep inspiration breath-hold technique for lung tumors: the potential value of target immobilization and reduced lung density in dose escalation. Int J Radiat Oncol Biol Phys 45:603–611

    Article  PubMed  CAS  Google Scholar 

  • Hanley J, Debois MM, Mah M et al. (1999b) Deep inspiration breath-hold technique for lung tumors: the potential value of target immobilization and reduced lung density in dose escalation. Int J Radiat Oncol Biol Phys 45:603–611

    Article  PubMed  CAS  Google Scholar 

  • Hara R, Itami J, Kondo T et al. (2002) Stereotactic single high dose irradiation of lung tumors under resperitory gating. Radiother Oncol 63:159–163

    Article  PubMed  Google Scholar 

  • Hartmann GH, Schlegel W, Sturm V et al. (1985) Cerebral radiation surgery using moving field irradiation at a linear accelerator facility. Int J Radiat Oncol Biol Phys 11:1185–1192

    PubMed  CAS  Google Scholar 

  • Hayakawa K, Mitsuhashi N, Saito Y (1999) Limited field irradiation for medically inoperable patients with peripheral stage I non-small cell lung cancer. Lung Cancer 26:137–142

    Article  PubMed  CAS  Google Scholar 

  • Herfarth KK, Debus J (2003) Stereotactic radiation therapy of liver tumors. Radiother Oncol 68(Suppl 1):S45

    Google Scholar 

  • Herfarth KK, Debus J, Lohr F et al. (2000a) Stereotactic single dose radiation treatment of tumors in the lung. Radiology 217 (Suppl):148

    Google Scholar 

  • Herfarth KK, Debus J, Lohr F et al. (2000b) Extracranial stereotactic radiation therapy: set-up accuracy of patients treated for liver metastases. Int J Radiat Oncol Biol Phys 46:329–335

    Article  PubMed  CAS  Google Scholar 

  • Herfarth KK, Pirzkall A, Lohr F et al. (2000c) Erste Erfahrungen mit einem nicht-invasiven Patientenfixierungssystem für die stereotaktische Strahlentherapie der Prostata. Strahlenther Onkol 176:217–222

    Article  PubMed  CAS  Google Scholar 

  • Herfarth KK, Debus J, Lohr F et al. (2001a) Stereotactic single dose radiation therapy of liver tumors: results of a phase I/II trial. J Clin Oncol 19:164–170

    PubMed  CAS  Google Scholar 

  • Herfarth KK, Debus J, Lohr F et al. (2001b) Stereotaktische Bestrahlung von Lebermetastasen. Radiologe 41:64–68

    Article  PubMed  CAS  Google Scholar 

  • Herfarth KK, Hof H, Bahner ML et al. (2003a) Assessment of focal liver reaction by multiphasic CT after stereotactic single-dose radiotherapy of liver tumors. Int J Radiat Oncol Biol Phys 57:444–451

    Article  PubMed  Google Scholar 

  • Herfarth KK, Münter MW, Debus J (2003b) Strahlentherapeutische Behandlung von Lebermetastasen. Chir Gastroenterol 19:359–363

    Article  Google Scholar 

  • Hof H, Herfarth KK, Munter M et al. (2003a) The use of the multislice CT for the determination of respiratory lung tumor movement in stereotactic single-dose irradiation. Strahlenther Onkol 179:542–547

    Article  PubMed  Google Scholar 

  • Hof H, Herfarth KK, Munter M et al. (2003b) Stereotactic single-dose radiotherapy of stage I non-small-cell lung cancer (NSCLC). Int J Radiat Oncol Biol Phys 56:335–341

    Article  PubMed  Google Scholar 

  • Hof H, Herfarth K, Wannenmacher M et al. (2004) Stereotaktische Bestrahlung von Lungentumoren: Erfahrungen mit einem Einzeitkonzept. Strahlenther Onkol 180(Suppl 1):17

    Google Scholar 

  • International Registry of Lung Metastases (1997) Long-term results of metastasectomy: prognostic analyses based on 5206 cases. J Thorac Cardiovasc Surg 113:37–49

    Google Scholar 

  • Koong AC, Le QT, Ho A et al. (2004) Phase I study of stereotactic radiosurgery in patients with locally advanced pancreatic cancer. Int J Radiat Oncol Biol Phys 58:1017–1021

    Article  PubMed  Google Scholar 

  • Lax I, Blomgren H, Näslund I et al. (1994) Stereotactic radiotherapy of malignancies in the abdomen. Acta Oncol 33:677–683

    PubMed  CAS  Google Scholar 

  • Leksell L (1951) The stereotactic method and radiosurgery of the brain. Acta Chir Scand 102:316–319

    PubMed  CAS  Google Scholar 

  • Lohr F, Debus J, Frank C et al. (1999) Noninvasive patient fixation for extracranial stereotactic radiotherapy. Int J Radiat Oncol Biol Phys 45:521–527

    PubMed  CAS  Google Scholar 

  • Mageras GS, Yorke E (2004) Deep inspiration breath hold and respiratory gating strategies for reducing organ motion in radiation treatment. Semin Radiat Oncol 14:65–75

    Article  PubMed  Google Scholar 

  • Milker-Zabel S, Zabel A, Thilmann C et al. (2003) Clinical results of retreatment of vertebral bone metastases by stereotactic conformal radiotherapy and intensity-modulated radiotherapy. Int J Radiat Oncol Biol Phys 55:162–167

    Article  PubMed  Google Scholar 

  • Minohara S, Kanai T, Endo M et al. (2000) Respiratory gated irradiation system for heavy-ion radiotherapy. Int J Radiat Oncol Biol Phys 47:1097–1103

    Article  PubMed  CAS  Google Scholar 

  • Nagata Y, Negoro Y, Aoki T et al. (2002) Clinical outcomes of 3D conformal hypofractionated single high-dose radiotherapy for one or two lung tumors using a stereotactic body frame. Int J Radiat Oncol Biol Phys 52:1041–1046

    Article  PubMed  Google Scholar 

  • Nakagawa K, Aoki Y, Tago M et al. (2000) Megavoltage CT-assisted stereotactic radiosurgery for thoracic tumors: original reseach in the treatment of thoracic neoplasms. Int J Radiat Oncol Biol Phys 48:449–457

    PubMed  CAS  Google Scholar 

  • Onishi H, Kuriyama K, Komiyama T et al. (2003) CT evaluation of patient deep inspiration self-breath-holding: How precisely can patients reproduce the tumor position in the absence of respiratory monitoring devices? Med Phys 30:1183–1187

    Article  PubMed  Google Scholar 

  • Onishi H, Araki T, Shirato H et al. (2004a) Stereotactic hypofractionated high-dose irradiation for stage I nonsmall cell lung carcinoma: clinical outcomes in 245 subjects in a Japanese multiinstitutional study. Cancer 101:1623–1631

    Article  PubMed  Google Scholar 

  • Onishi H, Kuriyama K, Komiyama T et al. (2004b) Clinical outcomes of stereotactic radiotherapy for stage I non-small cell lung cancer using a novel irradiation technique: patient self-controlled breath-hold and beam switching using a combination of linear accelerator and CT scanner. Lung Cancer 45:45–55

    Article  PubMed  Google Scholar 

  • Pirzkall A, Debus J, Lohr F et al. (1998) Radiosurgery alone or in combination with whole-brain radiotherapy for brain metastases. J Clin Oncol 16:3563–3569

    PubMed  CAS  Google Scholar 

  • Rosenzweig KE, Hanley J, Mah D et al. (2000) The deep inspiration breath-hold technique in the treatment of inoperable non-small-cell lung cancer. Int J Radiat Oncol Biol Phys 48:81–87

    PubMed  CAS  Google Scholar 

  • Ryu S, Fang Yin F, Rock J et al. (2003) Image-guided and intensity-modulated radiosurgery for patients with spinal metastasis. Cancer 97:2013–2018

    Article  PubMed  Google Scholar 

  • Starkschall G, Forster KM, Kitamura K et al. (2004) Correlation of gross tumor volume excursion with potential benefits of respiratory gating. Int J Radiat Oncol Biol Phys 60:1291–1297

    Article  PubMed  Google Scholar 

  • Takeda T, Takeda A, Kunieda E et al. (2004) Radiation injury after hypofractionated stereotactic radiotherapy for peripheral small lung tumors: serial changes on CT. Am J Roentgenol 182:1123–1128

    Google Scholar 

  • Thilmann C, Schulz-Ertner D, Zabel A et al. (2002) Intensitymodulated radiotherapy of sacral chordoma: a case report and a comparison with stereotactic conformal radiotherapy. Acta Oncol 41:395–399

    Article  PubMed  Google Scholar 

  • Timmerman R, Papiez L, McGarry R et al. (2003) Extracranial stereotactic radioablation: results of a phase I study in medically inoperable stage I non-small cell lung cancer. Chest 124:1946–1955

    Article  PubMed  Google Scholar 

  • Uematsu M, Shioda A, Tahara K et al. (1998) Focal, high dose, and fractionated modified stereotactic radiation therapy for lung carcinoma patients. Cancer 82:1062–1070

    Article  PubMed  CAS  Google Scholar 

  • Warner MA, Warner ME, Buck CF et al. (1988) Clinical efficacy of high frequency jet ventilation during extracorporal shock wave lithotripsy of renal and ureteral calculi: a comparison with conventional mechanical ventilation. J Urol 139:486–487

    PubMed  CAS  Google Scholar 

  • Willemart S, Nicaise N, Struyven J et al. (2000) Acute radiationinduced hepatic injury: evaluation by triphasic contrast enhanced helical CT. Br J Radiol 73:544–546

    PubMed  CAS  Google Scholar 

  • Wong J, Sharpe M, Jaffray D et al. (1999) The use of active breathing control (ABC) to reduce margin for breathing motion. Int J Radiat Oncol Biol Phys 44:911–919

    PubMed  CAS  Google Scholar 

  • Wulf J, Hädinger U, Oppitz U et al. (2000) Stereotactic radiotherapy of extracranial targets: CT-simulation and accuracy of treatment in the stereotactic body frame. Radiother Oncol 57:225–236

    Article  PubMed  CAS  Google Scholar 

  • Wulf J, Hädinger U, Oppitz U et al. (2001) Stereotactic radiotherapy of targets in the lung and liver. Strahlenther Onkol 177:645–655

    PubMed  CAS  Google Scholar 

  • Wulf J, Haedinger U, Oppitz U et al. (2004) Stereotactic radiotherapy of primary lung cancer and pulmonary metastases: a non-invasive treatment approach in medically inoperable patients. Int J Radiat Oncol Biol Phys 60:186–196

    Article  PubMed  Google Scholar 

  • Yin F, Kim JG, Haughton C et al. (2001) Extracranial radiosurgery: immobilizing liver motion in dogs using high-frequency jet ventilation and total intravenous anesthesia. Int J Radiat Oncol Biol Phys 49:211–216

    Article  PubMed  CAS  Google Scholar 

  • Zierhut D, Bettscheider C, Schubert K et al. (2001) Radiation therapy of stage I and II non-small cell lung cancer (NSCLC). Lung Cancer 34(Suppl) 3:S39–S43

    PubMed  Google Scholar 

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© 2006 Springer-Verlag Berlin Heidelberg

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Herfarth, K.K. (2006). Extracranial Stereotactic Radiation Therapy. In: Schlegel, W., Bortfeld, T., Grosu, AL. (eds) New Technologies in Radiation Oncology. Medical Radiology. Springer, Berlin, Heidelberg. https://doi.org/10.1007/3-540-29999-8_22

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  • DOI: https://doi.org/10.1007/3-540-29999-8_22

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-540-00321-2

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