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B Cell Development and Its Deregulation to Transformed States at the Pre-B Cell Receptor-Expressing Pre-BII Cell Stage

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Chronic Lymphocytic Leukemia

Part of the book series: Current Topics in Microbiology and Immunology ((CT MICROBIOLOGY,volume 294))

Abstract

This chapter will review the scenario of normal B cell development—from the decision of a lymphoid progenitor to enter the B-lineage, over the stages of the generation of the repertoires of antigen-receptor (immunoglobulin)-expressing cells, to the response of mature B cells to develop memory and plasma cells—highlighting some of the cellular stages and the molecular mechanisms that can generate and select transformed states of cells. The scenarios for pre-B lymphoma (lymphocytic leukaemia) development are discussed in more detail.

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Authors and Affiliations

  1. Department of Cell Biology, Biozentrum of the University of Basel, Klingelbergstrasse 50-70, 4056, Basel, Switzerland

    F. Melchers

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  1. F. Melchers
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© 2005 Springer-Verlag Berlin Heidelberg

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Melchers, F. (2005). B Cell Development and Its Deregulation to Transformed States at the Pre-B Cell Receptor-Expressing Pre-BII Cell Stage. In: Chronic Lymphocytic Leukemia. Current Topics in Microbiology and Immunology, vol 294. Springer, Berlin, Heidelberg. https://doi.org/10.1007/3-540-29933-5_1

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