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Measuring Disturbed Barrier Function in Atopic Eczema

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Handbook of Atopic Eczema
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References

  1. Nilsson E, Mikaelsson B, Andersson S (1985) Atopy, occupation and domestic work as risk factors for hand eczema in hospital workers. Contact Dermatitis 13:216–223

    CAS  PubMed  Google Scholar 

  2. Rystedt I. Hand eczema in patients with history of atopic manifestations in childhood. Acta Derm. Venereol (Stockh) 1985; 65:305–312

    CAS  Google Scholar 

  3. Rystedt I (1990) The role of atopy in occupational skin disease. In: Adams RM (ed) Occupational skin disease. Saunders, Philadelphia, pp 215–222

    Google Scholar 

  4. Seidenari S, Manzini BM, Danese P, Motolese A (1990) Patch and prick test study of 593 healthy subjects. Contact Dermatitis 23:162–167

    CAS  PubMed  Google Scholar 

  5. Svensson Ä (1988) Hand eczema: an evaluation of the frequency of atopic background and the difference in clinical pattern between patients with and without atopic dermatitis. Acta Derm Venereol (Stockh) 68:509–513

    CAS  Google Scholar 

  6. Meding B, Swanbeck G (1990) Predictive factors for hand eczema. Contact Dermatitis 23:154–161

    CAS  PubMed  Google Scholar 

  7. Stingeni L, Lapomarda V, Lisi P (1995) Occupational hand dermatitis in hospital environments. Contact Dermatitis 33:172–176

    CAS  PubMed  Google Scholar 

  8. Cronin E (1987) Dermatitis of the hands in caterers. Contact Dermatitis 17:265–269

    CAS  PubMed  Google Scholar 

  9. Pigatto PD, Polenghi MM, Altomare GF (1987) Occupational dermatitis in bakers: a clue for atopic contact dermatitis. Contact Dermatitis 16:263–271

    CAS  PubMed  Google Scholar 

  10. Bauer A, Bartsch R, Stadeler M, Schneider W, Grieshaber R, Wollina U, Gebhardt M (1998) Development of occupational skin diseases during vocational training in baker and confectioner apprentices: a follow-up study. Contact Dermatitis 39:307–311

    CAS  PubMed  Google Scholar 

  11. Susitaival P, Hannuksela M (1995) The 12-year prognosis of hand dermatosis in 896 Finnish farmers. Contact Dermatitis 32:233–237

    CAS  PubMed  Google Scholar 

  12. Meding B, Swanbeck G (1989) Epidemiology of different types of hand eczema in an industrial city. Acta Derm Venereol (Stockh) 69:227–233

    CAS  Google Scholar 

  13. Pinnagoda J, Tupker RA, Coenraads PJ, Nater JP (1989) Prediction of susceptibility to an irritant response by transepidermalwater loss. Contact Dermatitis 20:341–346

    CAS  PubMed  Google Scholar 

  14. Freeman S, Maibach HI (1988) Study of irritant contact dermatitis produced by repeat patch testing with sodium lauryl sulfate and assessed by visualmethods, transepidermal water loss and laser Doppler velocimetry. J Am Acad Dermatol 19:496–502

    CAS  PubMed  Google Scholar 

  15. Wilhelm KP, Maibach HI (1990) Susceptibility to irritant dermatitis induced by sodium lauryl sulfate. J Am Acad Dermatol 23:122–124

    CAS  PubMed  Google Scholar 

  16. Goh CL, Chia SE (1988) Skin irritability to sodium lauryl sulphate-as measured by skin water vapour loss-by sex and race. Clin Exp Dermatol 13:16–19

    CAS  PubMed  Google Scholar 

  17. Agner T (1991) Susceptibility of atopic dermatitis patients to irritant dermatitis caused by sodium lauryl sulphate. Acta Derm Venereol (Stockh) 71:296–300

    CAS  Google Scholar 

  18. Tupker RA, Pinnagoda J, Coenraads PJ, Nater JP (1990) Susceptibility to irritants: role of barrier function, skin dryness and history of atopic dermatitis. Br J Dermatol 123:199–205

    CAS  PubMed  Google Scholar 

  19. Seidenari S, Giusti G (1995) Objective assessment of the skin of children affected by atopic dermatitis: a study on pH, capacitance and TEWL in eczematous and clinically uninvolved skin. Acta Derm Venereol (Stockh) 75:429–433

    CAS  Google Scholar 

  20. Giusti G, Seidenari S (1998) La barriera cutanea nei bambini con dermatite atopica: valutazione strumentale in 200 pazienti e 45 controlli. Riv Ital Pediatr 24:954–959

    Google Scholar 

  21. Conti A, Di Nardo A, Seidenari S (1996) No alteration of biophysical parameters in the skin of subjects with respiratory atopy. Dermatology 192:317–320

    CAS  PubMed  Google Scholar 

  22. Di Nardo A, Wertz P, Giannetti A, Seidenari S (1998) Ceramide and cholesterol composition of the skin of patients with atopic dermatitis. Acta Derm Venereol (Stockh) 78: 27–30

    Google Scholar 

  23. Löffler H, Effendy I (1999) Skin susceptibility of atopic individuals. Contact Dermatitis 40:239–242

    PubMed  Google Scholar 

  24. Agner T (1991) Skin susceptibility in uninvolved skin of hand eczema patients and healthy controls. Br J Dermatol 125:140–146

    CAS  PubMed  Google Scholar 

  25. Werner Y (1986) The water content of the stratum corneum in patients with atopic dermatitis. Measurement with the Corneometer CM 420. Acta Derm Venereol (Stockh) 66:281–284

    CAS  Google Scholar 

  26. Lodén M, Olsson H, Axéll T, Werner Linde Y (1992) Friction, capacitance and transepidermal water loss (TEWL) in dry atopic and normal skin. Br J Dermatol 126:137–141

    PubMed  Google Scholar 

  27. Gollhausen R (1991) The phenomenon of irritable skin in atopic eczema. In: Ruzicka T, Ring J, Przybilla B (eds) Handbook of atopic eczema. Springer-Verlag, Berlin Heidelberg New York, pp 306–318

    Google Scholar 

  28. Seidenari S (1994) Reactivity to nickel sulfate at sodium lauryl sulfate pre-treated sites is higher in atopics: an echographic evaluation by means of image analysis performed on 20 MHz B-scan recordings. Acta Derm Venereol (Stockh) 74:245–249

    CAS  Google Scholar 

  29. Berardesca E, Fideli D, Borroni G, Rabbiosi G, Maibach HI (1990) In vivo hydration and water-retention capacity of stratum corneum in clinically uninvolved skin in atopic and psoriatic patients. Acta Derm Venereol (Stockh) 70: 400–404

    CAS  Google Scholar 

  30. Tanaka M, Okada M, Zhen YX, Inamura N, Kitano T, Shirai S, Sakamoto K, Inamura T, Tagami H (1998) Decreased hydration state of the stratum corneum and reduced amino acid content of the skin surface in patients with seasonal allergic rhinitis. Br J Dermatol 139:618–621

    CAS  PubMed  Google Scholar 

  31. Tagami H, Kanamaru Y, Inoue K (1982) Water sorption-desorption test of the skin in vivo for functional assessment of the stratum corneum. J Invest Dermatol 78:425–428

    Article  CAS  PubMed  Google Scholar 

  32. Werner Y, Lindberg M, Forslind B (1981) The water-binding capacity of stratum corneum in dry non-eczematous skin of atopic eczema. Acta Derm Venereol (Stockh) 62:334–337

    Google Scholar 

  33. Pellacani G, Seidenari S (2001) Water sorption-desorption test and moisture accumulation test for functional assessment of atopic skin in children. Acta Derm Venereol (Stockh) 81:100–103

    CAS  Google Scholar 

  34. Imokawa G, Akasaki S, Minematsu Y, Kawai M (1989) Importance of intercellular lipids in water-retention properties of the stratum corneum: induction and recovery study of surfactant dry skin. Arch Dermatol Res 281:45–51

    Article  CAS  PubMed  Google Scholar 

  35. Elias PM, Menon GK (1991) Structural and lipid biochemical correlates of the epidermal permeability barrier. Adv Lipid Res 24:1–26

    CAS  PubMed  Google Scholar 

  36. Grubauer G, Elias PM, Feingold KR (1989) Transepidermal water loss: the signal for recovery of barrier structure and function. J Lipid Res 30:323–333

    CAS  PubMed  Google Scholar 

  37. Melnik B, Hollmann J, Hofmann U, Yuh MS, Plewig G (1990) Lipid composition of outer stratum corneum and nails in atopic and control subjects. Arch Dermatol Res 282:549–551

    Article  CAS  PubMed  Google Scholar 

  38. Yamamoto A, Serizawa S, Ito M, Sato Y (1991) Stratum corneum lipid abnormalities in atopic dermatitis. Arch Dermatol Res 283:219–223

    Article  CAS  PubMed  Google Scholar 

  39. Schäfer L, Kragballe K (1991) Abnormalities in epidermal lipid metabolism in patients with atopic dermatitis. J Invest Dermatol 96:10–15

    PubMed  Google Scholar 

  40. Imokawa G, Abe A, Jin K, Higaki Y, Kawashima M, Hidano A (1991) Decreased level of ceramides in stratum corneum of atopic dermatitis: an etiologic factor in atopic dry skin? J Invest Dermatol 96:523–526

    CAS  PubMed  Google Scholar 

  41. Werner Y, Lindberg M, Forslind B (1987) Membrane-coating granules in “dry” non-eczematous skin of patients with atopic dermatitis. Acta Derm Venereol (Stockh) 67:385–390

    CAS  Google Scholar 

  42. Jin K, Higaki Y, Takagi Y, Higuchi K, Yada Y, Kawashima M (1994) Analysis of beta-glucocerebridase and ceramidase activities in atopic and aged dry skin. Acta Derm Venereol (Stockh) 74:337–340

    CAS  Google Scholar 

  43. Murata Y, Ogata J, Higaki Y, Kawashima M, Yada Y, Higuki K (1996) Abnormal expression of sphingomyelin acylase in atopic dermatitis: an etiologic factor for ceramide deficiency? J Invest Dermatol 106:1242–1249

    Article  CAS  PubMed  Google Scholar 

  44. Tanaka M, Zhen YX, Tagami H (1997) Normal recovery of the stratum corneum barrier function following damage induced by tape stripping in patients with atopic dermatitis. Br J Dermatol 136:966–967

    Article  CAS  PubMed  Google Scholar 

  45. Gfesser M, Abeck D, Rügemer J, Schreiner V, Stäb F, Disch R, Ring J (1997) The early phase of epidermal barrier regeneration is faster in patients with atopic eczema. Dermatology 195:332–336

    CAS  PubMed  Google Scholar 

  46. Di Nardo A, Sugino K, Ademola J, Wertz PW, Maibach HI (1996) Sodium lauryl sulfate induced irritant contact dermatitis: a correlation study between ceramides and in vivo parameters of irritation. Contact Dermatitis 35:86–91

    PubMed  Google Scholar 

  47. Di Nardo A, Sugino K, Ademola J, Wertz PW, Maibach HI (1996) Role of ceramides in proclivity to toluene and xylene-induced irritation in man. Derm Beruf Umwelt 44:119–125

    Google Scholar 

  48. Stolz R, Hinnen U, Elsner P (1997) An evaluation of the relationship between ‘atopic skin’ and skin irritability in metalworkers trainees. Contact Dermatitis 36:281–284

    CAS  PubMed  Google Scholar 

  49. Basketter DA, Miettinen J, Lahti A (1998) Acute irritant reactivity to sodium lauryl sulfate in atopics and nonatopics. Contact Dermatitis 38:253–257

    CAS  PubMed  Google Scholar 

  50. Hannuksela A, Hannuksela M (1996) Irritant effects of a detergent in wash, chamber and repeated open application tests. Contact Dermatitis 34:134–137

    CAS  PubMed  Google Scholar 

  51. Van der Valk PGM, Nater JP, Bleumink E (1985) Vulnerability of the skin to surfactants in different groups of eczema patients and controls as measured by water vapour loss. Clin Exp Dermatol 10:98–102

    PubMed  Google Scholar 

  52. Cowley NC, Farr PM (1992) A dose-response study of irritant reactions to sodium lauryl sulphate in patients with seborrhoeic dermatitis and atopic eczema. Acta Derm Venereol (Stockh) 72:432–435

    CAS  Google Scholar 

  53. Seidenari S, Belletti B, Schiavi ME (1996) Skin reactivity to sodium lauryl sulfate in patients with respiratory atopy. J Am Acad Dermatol 35:47–52

    Article  CAS  PubMed  Google Scholar 

  54. Seidenari S (1996) Skin sensitivity, interindividual factors: atopy. In: Van der Valk PG, Maibach HI (eds) The irritant contact dermatitis syndrome. CRC press, Boca Raton, pp 267–277

    Google Scholar 

  55. Seidenari S, Di Nardo A (1992) B-scanning evaluation of irritant reactions with binary transformation and image analysis. Acta Derm Venereol (Stockh) 175:9–13

    CAS  Google Scholar 

  56. Funke U, Diepgen TL, Fartash M (1996) Risk-group-related prevention of hand eczema at the workplace. Curr Probl Dermatol 25:123–132

    CAS  PubMed  Google Scholar 

  57. Conti A, Seidenari S (2000) No increased skin reactivity in subjects with allergic rhinitis during the active phase of the disease. Acta Derm Venereol 80:192–195

    CAS  PubMed  Google Scholar 

  58. Nassif A, Chang SC, Storrs SJ, Hanifin JM(1994) Abnormal skin irritancy in atopic dermatitis and atopy without dermatitis. Arch Dermatol 130:1401–1407

    Article  Google Scholar 

  59. Aalto-Korte K (1995) Improvement of skin barrier function during treatment of atopic dermatitis. J Am Acad Dermatol 33:969–972

    CAS  PubMed  Google Scholar 

  60. Loden M (1997) Barrier recovery and influence of irritant stimuli in skin treated with a moisturising cream. Contact Dermatitis 36:256–260

    CAS  PubMed  Google Scholar 

  61. Held E, Sveinsdottir A, Agner T (1999) Effect of long-term use of a moisturiser on skin hydration, barrier function and susceptibility to irritants. Acta Derm Venereol (Stockh) 79:49–51

    CAS  Google Scholar 

  62. Loden M, Andersson AC, Lindberg M (1999) Improvement in skin barrier function in patients with atopic dermatitis after treatment with a moisturizing cream (Canoderm®). Br J Dermatol 140:264–267

    Article  CAS  PubMed  Google Scholar 

  63. Loden M, Andersson AC, Andersson C, Frödin T, Öman H, Lindberg M (2001) Instrumental and dermatological evaluation of the effect of glycerin and urea on dry skin in atopic dermatitis. Skin Res Technol 7:209–213

    Article  CAS  PubMed  Google Scholar 

  64. Chamlin SL, Kao J, Frieden IJ, Sheu MY, Fowler AJ, Fluhr JW, Williams ML, Elias PM (2002) Ceramide-dominant barrier repair lipids alleviate childhood atopic dermatitis: changes in barrier function provide a sensitive indicator of disease activity. J Am Acad Dermatol 47:198–208

    Article  PubMed  Google Scholar 

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Seidenari, S., Giusti, F. (2006). Measuring Disturbed Barrier Function in Atopic Eczema. In: Ring, J., Przybilla, B., Ruzicka, T. (eds) Handbook of Atopic Eczema. Springer, Berlin, Heidelberg. https://doi.org/10.1007/3-540-29856-8_49

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