Hepatitis Delta Virus Genetic Variability: From Genotypes I, II, III to Eight Major Clades?

Part of the Current Topics in Microbiology and Immunology book series (CT MICROBIOLOGY, volume 307)


Hepatitis D virus (HDV) is a satellite of hepatitis B virus (HBV) for transmission and propagation, and infects nearly 20 million people worldwide. The HDV genome is composed of a compact circular single-stranded negative RNA genome with extensive intramolecular complementarity. Along with epidemiological, geographic distribution and pathological patterns, the variability of HDV has been limited to three genotypes and two subtypes that have been characterized to date. Recently, extensive phylogenetic reconstructions based on the delta antigen gene and full-length genome sequence data, have shown a wide and probably ancient radiation of African lineages, suggesting that the genetic variability of HDV is much more complex than previously thought. Indeed, sequences previously affiliated with genotype IIb should now be considered as belonging to clade 4 (HDV-4) and African HDV sequences segregate within four additional clades: HDV-5, HDV-6, HDV-7 and HDV-8. These results bring the geographic distribution of HDV closer to the genetic variability of its helper HBV.


Neighbour Join Editing Site Hepatitis Delta Virus Hepatitis Delta Virus Hepatitis Delta Virus Infection 
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© Springer-Verlag Berlin Heidelberg 2006

Authors and Affiliations

  1. 1.Service de Bactériologie, Virologie, Hygiène, Laboratoire Associé au Centre National de Référence des hépatites B et C, Hôpital Avicenne, Assistance Publique — Hôpitaux de ParisUniversité Paris 13, EA3406Bobigny CedexFrance

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