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Hepatitis Delta Virus pp 151–171Cite as

Hepatitis Delta Virus Genetic Variability: From Genotypes I, II, III to Eight Major Clades?

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Part of the book series: Current Topics in Microbiology and Immunology ((CT MICROBIOLOGY,volume 307))

Abstract

Hepatitis D virus (HDV) is a satellite of hepatitis B virus (HBV) for transmission and propagation, and infects nearly 20 million people worldwide. The HDV genome is composed of a compact circular single-stranded negative RNA genome with extensive intramolecular complementarity. Along with epidemiological, geographic distribution and pathological patterns, the variability of HDV has been limited to three genotypes and two subtypes that have been characterized to date. Recently, extensive phylogenetic reconstructions based on the delta antigen gene and full-length genome sequence data, have shown a wide and probably ancient radiation of African lineages, suggesting that the genetic variability of HDV is much more complex than previously thought. Indeed, sequences previously affiliated with genotype IIb should now be considered as belonging to clade 4 (HDV-4) and African HDV sequences segregate within four additional clades: HDV-5, HDV-6, HDV-7 and HDV-8. These results bring the geographic distribution of HDV closer to the genetic variability of its helper HBV.

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Authors and Affiliations

  1. Service de Bactériologie, Virologie, Hygiène, Laboratoire Associé au Centre National de Référence des hépatites B et C, Hôpital Avicenne, Assistance Publique — Hôpitaux de Paris, Université Paris 13, EA3406, 93009, Bobigny Cedex, France

    P. Dény

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  1. Department of Microbiology and Immunology, Georgetown University, 3900 Reservoir Road, NW, Washington, DC, 20007, USA

    John L. Casey Ph.D.

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Dény, P. (2006). Hepatitis Delta Virus Genetic Variability: From Genotypes I, II, III to Eight Major Clades?. In: Casey, J.L. (eds) Hepatitis Delta Virus. Current Topics in Microbiology and Immunology, vol 307. Springer, Berlin, Heidelberg . https://doi.org/10.1007/3-540-29802-9_8

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