Post-translational Modification of Delta Antigen of Hepatitis D Virus

Part of the Current Topics in Microbiology and Immunology book series (CT MICROBIOLOGY, volume 307)


The hepatitis delta virus (HDV) genome has only one open reading frame, which encodes the viral small delta antigen. After RNA editing, the same open reading frame is extended 19 amino acids at the carboxyl terminus and encodes the large delta antigen. These two viral proteins escort the HDV genome through different cellular compartments for the complicated phases of replication, transcription and, eventually, the formation of progeny virions. To orchestrate these events, the delta antigens have to take distinct cues to traffic to the right compartments and make correct molecular contacts. In eukaryotes, post-translational modification (PTM) is a major mechanism of dictating the multiple functions of a single protein. Multiple PTMs, including phosphorylation, isoprenylation, acetylation, and methylation, have been identified on hepatitis delta antigens. In this chapter we review these PTMs and discuss their functions in regulating and coordinating the life cycle of HDV.


K72R Mutant Nuclear Speckle Arginine Methylation Acetylation Site Delta Antigen 
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© Springer-Verlag Berlin Heidelberg 2006

Authors and Affiliations

  1. 1.Graduate Institute of Clinical Medicine, College of MedicineNational Taiwan UniversityTaipeiTaiwan
  2. 2.Hepatitis Research CenterNational Taiwan University HospitalTaipeiTaiwan

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