The Woodchuck Model of HDV Infection

Part of the Current Topics in Microbiology and Immunology book series (CT MICROBIOLOGY, volume 307)


The Eastern woodchuck, Marmota monax, has been a useful model system for the study of the natural history of hepadnavirus infection and for the development and preclinical testing of antiviral therapies. The model has also been used for hepatitis delta virus (HDV). In this chapter several new applications of the woodchuck model of HDV infection are presented and discussed. The development of a woodchuck HDV inoculum derived from a molecular clone has facilitated the analysis of viral genetic changes occurring during acute and chronic infection. This analysis has provided insights into one of the more important aspects of the natural history of HDV infection—whether a superinfection becomes chronic. These results could renew interest in further vaccine development. An effective therapy for chronic HDV infection remains an important clinical goal for this agent, particularly because of the severity of the disease and the inability of current hepadnaviral therapies to ameliorate it. The recent application of the woodchuck model of chronic HDV infection to therapeutic development has yielded promising results which indicate that targeting the hepadnavirus surface protein may be a successful therapeutic strategy for HDV.


Hepatitis Delta Virus HBsAg Level Woolly Monkey Woodchuck Hepatitis Virus Hepatitis Delta Virus Infection 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


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Copyright information

© Springer-Verlag Berlin Heidelberg 2006

Authors and Affiliations

  1. 1.Department of Microbiology and ImmunologyGeorgetown University Medical CenterWashington, DCUSA
  2. 2.Department of Microbiology and Immunology and Division of Molecular Virology and ImmunologyGeorgetown University Medical CenterWashington, DCUSA

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