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References
Bino RJ, Hall RD, Fiehn O, Kopka J, Saito K, Draper J, Nikolau BJ, Mendes P, Roessner-Tunali U, Beale MH, Trethewey RN, Lange BM, Wurtele ES, Sumner LW (2004) Potential of metabolomics as a functional genomics tool. Trends Plant Sci 9:418–425
Birkemeyer C, Kolasa A, Kopka J (2003) Comprehensive chemical derivatization for gas chromatography-mass spectrometry-based multi-targeted profiling of the major phytohormones. J Chromatogr A 993:89–102
Broeckling CD, Huhman DV, Farag MA, Smith JT, May GD, Mendes P, Dixon RA, Sumner LW (2005) Metabolic profiling of Medicago truncatula cell cultures reveals the effects of biotic and abiotic elicitors on metabolism. J Exp Bot 56:323–336
Chester T, Parcher JF (2001) Blurring the Boundaries. Science 291:502–503
Chester T, Pinkston J (2002) Supercritical fluid and unified chromatography. Anal Chem 74:2801–2811
Dixon RA (2001) Phytochemistry in the genomics and post-genomics eras. Phytochemistry 57:145–148
Djordjevic N, Houdiere F, Fowler P (1998) High temperature and temperature programming in capillary HPLC. Biomed Chromatogr 12:153–154
Djordjevic N, Fitzpatrick F, Houdiere F, Lerch G, Rozing G (2000) High temperature and temperature programming in capillary electrochromatography. J Chromatogr A 887:245–252
Djordjevic NM, Fowler PWJ, Houdiere F (1999) High temperature and temperature programming in high-performance liquid chromatography: Instrumental considerations. J Microcolumn Separ 11:403–413
Evans C, Jorgenson J (2004) Multidimensional LC-LC and LC-CE for high-resolution separations of biological molecules. Anal Bioanal Chem 378:1952–1961
Fiehn O, Kopka J, Dormann P, Altmann T, Trethewey RN, Willmitzer L (2000) Metabolite profiling for plant fuctional genomics. Nat Biotechnol 18:1142–1161
Guevremont R (2004) High-field asymmetric waveform ion mobility spectrometry: a new tool for mass spectrometry. J Chromatogr A 1058:3–19
Gygi SP, Rochon Y, Franza BR, Aebersold R (1999) Correlation between protein and mRNA abundance in yeast. Mol Cell Biol 19:1720–1730
Hartman T, Kutchan TM, Strack D (2005) Evolution of metabolic diversity. Phytochemistry 66:1198–1199
Kapron J, Jemal M, Duncan G, Kolakowski B, Purves R (2005) Removal of metabolite interference during liquid chromatography/tandem mass spectrometry using high-field asymmetric waveform ion mobility spectrometry. Rapid Commun Mass Spectrom 19:1979–1983
Lee Y, Hoaglund-Hyzera C, Srebalus Barnes C, Hilderbrand A, Valentine S, Clemmer D (2002) Development of high-throughput liquid chromatography injected ion mobility quadrupole time-of-flight techniques for analysis of complex peptide mixtures. J Chromatogr B Anal Technol Biomed Life Sci 782:343–351
Legido-Quigley C, Marlin N, Melin V, Manz A, Smith N (2003) Advances in capillary electrochromatography and micro-high performance liquid chromatography monolithic columns for separation science. Electrophoresis 24:917–944
Liu X, Plasencia M, Ragg S, Valentine S, Clemmer D (2004) Development of high throughput dispersive LC-ion mobility-TOFMS techniques for analysing the human plasma proteome. Brief Funct Genomic Proteomic 3:177–186
Luo Z, Xiong Y, Parcher J (2003) Chromatography with dynamically created liquid “stationary” phases: methanol and carbon dioxide. Anal Chem 75:3557–3562
MacNair J, Lewis K, Jorgenson J (1997) Ultrahigh-pressure reversed-phase liquid chromatography in packed capillary columns. Anal Chem 69:983–989
MacNair J, Patel K, Jorgenson J (1999) Ultrahigh-pressure reversed-phase capillary liquid chromatography: isocratic and gradient elution using columns packed with 1.0-micron particles. Anal Chem 71:700–708
Matz L, Dion H, Hill H (2002) Evaluation of capillary liquid chromatography-electrospray ionization ionmobility spectrometry with mass spectrometry detection. J Chromatogr A946:59–68
Mondello L, Lewis AC, Bartle KD (2002) Multidimensional Chromatography. Wiley, Chichester, UK
Oliver DJ, Nikolau B, Wurtele ES (2002) Functional genomics: high-throughput mRNA, protein, and metabolite analyses. Metab Eng 4:98–106
Patel K, Jerkovich A, Link J, Jorgenson J (2004) In-depth characterization of slurry packed capillary columns with 1.0-microm nonporous particles using reversed-phase isocratic ultrahigh-pressure liquid chromatography. Anal Chem 76:5777–5786
Que A, Novotny M (2002) Separation of neutral saccharide mixtures with capillary electrochromatography using hydrophilic monolithic columns. Anal Chem 74:5184–5191
Roessner U, Wagner C, Kopka J, Trethewey RN, Willmitzer L (2000) Simultaneous analysis of metabolites in potato tuber by gas chromatography-mass spectrometry. Plant J 23:131–142
Roessner U, Luedemann A, Brust D, Fiehn O, Linke T, Willmitzer L, Fernie AR (2001) Metabolic profiling allows comprehensive phenotyping of genetically or environmentally modified plant systems. Plant Cell 13:11–29
Schauer N, Steinhauser D, Strelkov S, Schomburg D, Allison G, Moritz T, Lundgren K, Roessner-Tunali U, Forbes M, Willmitzer L, Fernie A, Kopka J (2005) GC-MS libraries for the rapid identification of metabolites in complex biological samples. FEBS Lett 579:1332–1337
Shen Y, Zhang R, Moore R, Kim J, Metz T, Hixson K, Zhao R, Livesay E, Udseth H, Smith R (2005) Automated 20 kpsi RPLC-MS and MS/MS with chromatographic peak capacities of 1000–1500 and capabilities in proteomics and metabolomics. Anal Chem 77:3090–3100
Shvartsburg A, Tang K, Smith R (2005) Optimization of the design and operation of FAIMS analyzers. J Am Soc Mass Spectrom 16:2–12
Somerville C, Dangl J (2000) Plant biology in 2010. Science 290:2077–2078
Somerville C, Somerville S (1999) Plant functional genomics. Science 285:380–383
Sumner LW, Mendes P, Dixon RA (2003) Plant metabolomics: large-scale phytochemistry in the functional genomics era. Phytochemistry 62:817–836
Takats Z, Wiseman JM, Gologan B, Cooks RG (2004) Mass spectrometry sampling under ambient conditions with desorption electrospray ionization. Science 306:471–473
Tanaka N, Kimura H, Tokuda D, Hosoya K, Ikegami T, Ishizuka N, Minakuchi H, Nakanishi K, Shintani Y, Furuno M, Cabrera K (2004) Simple and comprehensive two-dimensional reversed-phase HPLC using monolithic silica columns. Anal Chem 76:1273–1281
Tolley L, Jorgenson J, Moseley M (2001) Very high pressure gradient LC/MS/MS. Anal Chem 73:2985–2991
Tolstikov VV, Lommen A, Nakanishi K, Tanaka N, Fiehn O (2003) Monolitichic silica-based capillary reversed-phase liquid chromatography/electrospray mass spectrometry for plant metabolomics. Anal Chem 75:6737–6740
Trethewey RN (2001) Gene discovery via metabolic profiling. Curr Opin Biotechnol 12:135–138
Trethewey RN, Krotzky AJ, Willmitzer L (1999) Metabolic profiling: a rossetta stone for genomics? Curr Opin Plant Biol 2:83–85
Verbeck G, Ruotolo B, Sawyer H, Gillig K, Russell D (2002) A fundamental introduction to ion mobility mass spectrometry applied to the analysis of biomolecules. J Biomol Tech 13:56–61
Wagner C, Sefkow M, Kopka J (2003) Construction and application of a mass spectral and retention time index database generated from plant GC/EI-TOF-MS metabolite profiles. Phytochemistry 62:887–900
Washburn M, Wolters D, Yates J (2001) Large-scale analysis of the yeast proteome by multidimensional protein identification technology. Nat Biotechnol 19:242–247
Weckwerth W (2003) Metabolomics in systems biology. Annu Rev Plant Biol 54:669–689
Wells P, Zhou S, Parcher J (2002) Gas-liquid chromatography with a volatile “stationary” liquid phase. Anal Chem 74:2103–2111
Wells P, Zhou S, Parcher J (2003) Unified chromatography with CO2-based binarymobile phases. Anal Chem 75:18A–24A
Welthagen W, Shellie RA, Spranger J, Ristow M, Zimmermannn R, Fiehn O (2005) Comprehensive two-dimensional gas chromatography-time-of-flight mass spectrometry (GC×GC-TOF) for high resolution metabolomics: biomarker discovery on spleen tissue extracts of obese NZO compared to lean C57BL/6 mice. Metabolomics 1:65–73
Wilson I, Nicholson J, Castro-Perez J, Granger J, Johnson K, Smith B, Plumb R (2005) High resolution “ultra performance” liquid chromatography coupled to oa-TOFmass spectrometry as a tool for differential metabolic pathway profiling in functional genomic studies. J Proteome Res 4:591–598
Wolters D, Washburn M, Yates J (2001) An automated multidimensional protein identification technology for shotgun proteomics. Anal Chem 73:5683–5690
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Sumner, L.W. (2006). Current Status and Forward Looking Thoughts on LC/MS Metabolomics. In: Saito, K., Dixon, R.A., Willmitzer, L. (eds) Plant Metabolomics. Biotechnology in Agriculture and Forestry, vol 57. Springer, Berlin, Heidelberg. https://doi.org/10.1007/3-540-29782-0_2
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DOI: https://doi.org/10.1007/3-540-29782-0_2
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