Skip to main content

AraCyc: Overview of an Arabidopsis Metabolism Database and its Applications for Plant Research

  • Chapter
Plant Metabolomics

Part of the book series: Biotechnology in Agriculture and Forestry ((AGRICULTURE,volume 57))

6 Conclusions

Currently we are experiencing a rapidly increasing rate of production of large-scale data such as genome sequences, genome-wide gene expression profiles, proteomics and metabolomics data. The necessity to organize all of these data into a biological framework has been, in part, the motivation for the work described in this review. While we have created a comprehensive database that describes the metabolic network of a model plant species, Arabidopsis thaliana, the database is far from being either complete or error-free. Many of the pathways are in need of manual curation using the current literature and many more pathways, particularly those for secondary metabolism and those that include transport reactions, need to be brought into the database. As with any other database project, the content of the AraCyc database is dynamic and will continue to undergo enhancement, additions, and modifications to make it more useful.

This is a preview of subscription content, log in via an institution to check access.

Access this chapter

Chapter
USD 29.95
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
eBook
USD 169.00
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
Softcover Book
USD 219.99
Price excludes VAT (USA)
  • Compact, lightweight edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info
Hardcover Book
USD 219.99
Price excludes VAT (USA)
  • Durable hardcover edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Purchases are for personal use only

Institutional subscriptions

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

References

  • AGI (2000) Analysis of the genome sequence of the flowering plant Arabidopsis thaliana. Nature 408:796–815

    Article  Google Scholar 

  • Berardini TZ, Mundodi S, Reiser L, Huala E, Garcia-Hernandez M, Zhang P, Mueller LA, Yoon J, Doyle A, Lander G, Moseyko N, Yoo D, Xu I, Zoeckler B, Montoya M, Miller N, Weems D, Rhee SY (2004) Functional annotation of the Arabidopsis genome using controlled vocabularies. Plant Physiol 135:745–755

    Article  PubMed  CAS  Google Scholar 

  • Cook D, Fowler S, Fiehn O, Thomashow MF (2004) A prominent role for the CBF cold response pathway in configuring the low-temperature metabolome of Arabidopsis. Proc Natl Acad Sci USA 101:15243–15248

    Article  PubMed  CAS  Google Scholar 

  • Dickerson JA, Yang Y, Blom K, Reinot A, Lie J, Cruz-Neira C, Wurtele ES (2003) Using virtual reality to understand complex metabolic networks. Atlantic symposium on computational biology and genomic information systems and technology, september, pp 950–953

    Google Scholar 

  • Gilmour SJ, Fowler SG, Thomashow MF (2004) Arabidopsis transcriptional activators CBF1, CBF2, and CBF3 have matching functional activities. Plant Mol Biol 54:767–781

    Article  PubMed  CAS  Google Scholar 

  • Goff SA, Ricke D, Lan TH, Presting G, Wang R, Dunn M, Glazebrook J, Sessions A, Oeller P, Varma H, Hadley D, Hutchison D, Martin C, Katagiri F, Lange BM, Moughamer T, Xia Y, Budworth P, Zhong J, Miguel T, Paszkowski U, Zhang S, Colbert M, Sun WL, Chen L, Cooper B, Park S, Wood TC, Mao L, Quail P, Wing R, Dean R, Yu Y, Zharkikh A, Shen R, Sahasrabudhe S, Thomas A, Cannings R, Gutin A, Pruss D, Reid J, Tavtigian S, Mitchell J, Eldredge G, Scholl T, Miller RM, Bhatnagar S, Adey N, Rubano T, Tusneem N, Robinson R, Feldhaus J, Macalma T, Oliphant A, Briggs S (2002) Adraft sequence of the rice genome (Oryza sativa L. ssp. japonica). Science 296:92–100

    Article  PubMed  CAS  Google Scholar 

  • Gruber TR (1993) A translation approach to portable ontology specifications. Knowledge Acquisition 5:199–220

    Article  Google Scholar 

  • Kanehisa M (2002) The KEGG database. Novartis Found Symp 247:91–101; discussion 101–103, 119–128, 244–152

    Article  PubMed  CAS  Google Scholar 

  • Kanehisa M, Goto S, Kawashima S, Okuno Y, Hattori M (2004) The KEG Gresource for deciphering the genome. Nucleic Acids Res 32:D277–D280

    Article  PubMed  CAS  Google Scholar 

  • Karp PD (2000) An ontology for biological function based on molecular interactions. Bioinformatics 16:269–285

    Article  PubMed  CAS  Google Scholar 

  • Karp PD, Paley S, Romero P (2002) The pathway tools software. Bioinformatics 18[Suppl 1]:S225–S232

    PubMed  Google Scholar 

  • Karp PD, Paley S, Krieger CJ, Zhang P (2004) An evidence ontology for use in pathway/genome databases. Pacific Symp Biocomput 9:190–201

    Google Scholar 

  • Krieger CJ, Zhang P, Mueller LA, Wang A, Paley S, Arnaud M, Pick J, Rhee SY, Karp PD (2004) MetaCyc: a multiorganism database of metabolic pathways and enzymes. Nucleic Acids Res 32:D438–D442

    Article  PubMed  CAS  Google Scholar 

  • Maranas CD, Burgard AP (2001) Review of EcoCyc and MetaCyc databases. Metab Eng 3:98–99

    Article  CAS  Google Scholar 

  • Mueller LA, Zhang P, Rhee SY (2003) AraCyc: a biochemical pathway database for Arabidopsis. Plant Physiol 132:453–460

    Article  PubMed  CAS  Google Scholar 

  • Ogata H, Goto S, Sato K, Fujibuchi W, Bono H, Kanehisa M (1999) KEGG: Kyoto encyclopedia of genes and genomes. Nucleic Acids Res 27:29–34

    Article  PubMed  CAS  Google Scholar 

  • Paley SM, Karp PD (2002) Evaluation of computational metabolic-pathway predictions for Helicobacter pylori. Bioinformatics 18:715–724

    Article  PubMed  CAS  Google Scholar 

  • Rohde P, Hincha DK, Heyer AG (2004) Heterosis in the freezing tolerance of crosses between two Arabidopsis thaliana accessions (Columbia-0 and C24) that show differences in non-acclimated and acclimated freezing tolerance. Plant J 38:790–799

    Article  PubMed  CAS  Google Scholar 

  • Selkov E, Basmanova S, Gaasterland T, Goryanin I, Gretchkin Y, Maltsev N, Nenashev V, Overbeek R, Panyushkina E, Pronevitch L, Selkov E Jr, Yunus I (1996) The metabolic pathway collection from EMP: the enzymes and metabolic pathways database. Nucleic Acids Res 24:26–28

    Article  PubMed  CAS  Google Scholar 

  • Shinozaki K, Yamaguchi-Shinozaki K, Seki M (2003) Regulatory network of gene expression in the drought and cold stress responses. Curr Opin Plant Biol 6:410–417

    Article  PubMed  CAS  Google Scholar 

  • Stitt M, Hurry V (2002) A plant for all seasons: alterations in photosynthetic carbon metabolism during cold acclimation in Arabidopsis. Curr Opin Plant Biol 5:199–206

    Article  PubMed  CAS  Google Scholar 

  • Strand A, Hurry V, Henkes S, Huner N, Gustafsson P, Gardestrom P, Stitt M (1999) Acclimation of Arabidopsis leaves developing at low temperatures. Increasing cytoplasmic volume accompanies increased activities of enzymes in the Calvin cycle and in the sucrose-biosynthesis pathway. Plant Physiol 119:1387–1398

    Article  PubMed  CAS  Google Scholar 

  • Taji T, Ohsumi C, Iuchi S, Seki M, Kasuga M, Kobayashi M, Yamaguchi-Shinozaki K, Shinozaki K (2002) Important roles of drought-and cold-inducible genes for galactinol synthase in stress tolerance in Arabidopsis thaliana. Plant J 29:417–426

    Article  PubMed  CAS  Google Scholar 

  • Thimm O, Blasing O, Gibon Y, Nagel A, Meyer S, Kruger P, Selbig J, Muller LA, Rhee SY, Stitt M (2004) MAPMAN: a user-driven tool to display genomics data sets onto diagrams of metabolic pathways and other biological processes. Plant J 37:914–939

    Article  PubMed  CAS  Google Scholar 

  • Thomashow MF (1999) Plant cold acclimation: freezing tolerance genes and regulatory mechanisms. Annu Rev Plant Physiol Plant Mol Biol 50:571–599

    Article  PubMed  CAS  Google Scholar 

  • Uemura M, Warren G, Steponkus PL (2003) Freezing sensitivity in the sfr4mutant of Arabidopsis is due to low sugar content and is manifested by loss of osmotic responsiveness. Plant Physiol 131:1800–1807

    Article  PubMed  CAS  Google Scholar 

  • Vogel JT, Zarka DG, Van Buskirk HA, Fowler SG, Thomashow MF (2005) Roles of the CBF2 and ZAT12 transcription factors in configuring the low temperature transcriptome of Arabidopsis. Plant J 41:195–211

    Article  PubMed  CAS  Google Scholar 

  • Weckwerth W, Wenzel K, Fiehn O (2004) Process for the integrated extraction, identification and quantification of metabolites, proteins and RNA to reveal their co-regulation in biochemical networks. Proteomics 4:78–83

    Article  PubMed  CAS  Google Scholar 

  • Wurtele ES, Li J, Diao L, Zhang H, Foster CM, Fatland B, Dickerson JA, Brown A, Cox Z, Cook D, Lee E-K, Hofmann H (2003) MetNet: Software to build and model the biogenetic lattice of Arabidopsis. Comp Funct Genom 4:239–245

    Article  CAS  Google Scholar 

  • Yu J, Hu S, Wang J, Wong GK, Li S, Liu B, Deng Y, Dai L, Zhou Y, Zhang X, Cao M, Liu J, Sun J, Tang J, Chen Y, Huang X, Lin W, Ye C, Tong W, Cong L, Geng J, Han Y, Li L, Li W, Hu G, Li J, Liu Z, Qi Q, Li T, Wang X, Lu H, Wu T, Zhu M, Ni P, Han H, Dong W, Ren X, Feng X, Cui P, Li X, Wang H, Xu X, Zhai W, Xu Z, Zhang J, He S, Xu J, Zhang K, Zheng X, Dong J, Zeng W, Tao L, Ye J, Tan J, Chen X, He J, Liu D, Tian W, Tian C, Xia H, Bao Q, Li G, Gao H, Cao T, Zhao W, Li P, Chen W, Zhang Y, Hu J, Liu S, Yang J, Zhang G, Xiong Y, Li Z, Mao L, Zhou C, Zhu Z, Chen R, Hao B, Zheng W, Chen S, Guo W, Tao M, Zhu L, Yuan L, Yang H (2002) A draft sequence of the rice genome (Oryza sativa L. ssp. indica). Science 296:79–92

    Article  PubMed  CAS  Google Scholar 

  • Zhang P, Foerster H, Tissier CP, Mueller LA, Paley S, Karp PD, Rhee SY (2005) MetaCyc and AraCyc: metabolic pathway databases for plant research. Plant Physiol 138:27–37

    Article  PubMed  CAS  Google Scholar 

  • Zuther E, Buchel K, Hundertmark M, Stitt M, Hincha DK, Heyer AG (2004) The role of raffinose in the cold acclimation response of Arabidopsis thaliana. FEBS Lett 576:169–173

    Article  PubMed  CAS  Google Scholar 

Download references

Author information

Authors and Affiliations

Authors

Editor information

Editors and Affiliations

Rights and permissions

Reprints and permissions

Copyright information

© 2006 Springer-Verlag Berlin Heidelberg

About this chapter

Cite this chapter

Rhee, S.Y., Zhang, P., Foerster, H., Tissier, C. (2006). AraCyc: Overview of an Arabidopsis Metabolism Database and its Applications for Plant Research. In: Saito, K., Dixon, R.A., Willmitzer, L. (eds) Plant Metabolomics. Biotechnology in Agriculture and Forestry, vol 57. Springer, Berlin, Heidelberg. https://doi.org/10.1007/3-540-29782-0_11

Download citation

Publish with us

Policies and ethics