Keywords
- Septic Shock
- Severe Sepsis
- Acute Respiratory Distress Syndrome
- Lower Tidal Volume
- Survive Sepsis Campaign Guideline
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.
This is a preview of subscription content, log in via an institution.
Buying options
Tax calculation will be finalised at checkout
Purchases are for personal use only
Learn about institutional subscriptionsPreview
Unable to display preview. Download preview PDF.
References
Armstrong GL, Conn LA, Pinner RW (1999) Trends in infectious disease mortality in the United States during the 20th century. JAMA 281:61–66
Padkin A, Goldfrad C, Brady AR, Young D, Black N, Rowan K (2003) Epidemiology of severe sepsis occurring in the first 24 hrs in intensive care units in England, Wales, and Northern Ireland. Crit Care Med 31:2332–2338
Hebert PC, Wells G, Blajchman MA, et al (1999) A multicenter, randomized, controlled clinical trial of transfusion requirements in critical care. Transfusion Requirements in Critical Care Investigators, Canadian Critical Care Trials Group. N Engl J Med 340:409–417
The Acute Respiratory Distress Syndrome Network (2000) Ventilation with lower tidal volumes as compared with traditional tidal volumes for acute lung injury and the acute respiratory distress syndrome. N Engl J Med 342:1301–1308
Singer M, De Santis V, Vitale D, Jeffcoate W (2004) Multiorgan failure is an adaptive, endocrine-mediated, metabolic response to overwhelming systemic inflammation. Lancet. 364:545–548
De Backer D, Creteur J, Preiser JC, Dubois MJ, Vincent JL (2002) Microvascular blood flow is altered in patients with sepsis. Am J Respir Crit Care Med 166:98–104
Vandermeer TJ, Wang H, Fink MP (1995) Endotoxemia causes ileal mucosal acidosis in the absence of mucosal hypoxia in a normodynamic porcine model of septic shock. Crit Care Med 23:1217–1226
Rosser DM, Stidwill RP, Jacobson D, Singer M (1995) Oxygen tension in the bladder epithelium increases in both high and low output endotoxemic sepsis. J Appl Physiol 79:1878–1882
Boekstegers P, Weidenhofer S, Kapsner T, Werdan K (1994) Skeletal muscle partial pressure of oxygen in patients with sepsis. Crit Care Med 22:640–650
Hotchkiss RS, Swanson PE, Freeman BD, et al (1999) Apoptotic cell death in patients with sepsis, shock, and multiple organ dysfunction. Crit Care Med 27:1230–1251
Brealey D, Karyampudi S, Jacques TS, et al (2004) Mitochondrial dysfunction in a long-term rodent model of sepsis and organ failure. Am J Physiol Regul Integr Comp Physiol 286:R491–R497
Brealey D, Brand M, Hargreaves I, et al (2002) Association between mitochondrial dysfunction and severity and outcome of septic shock. Lancet 360:219–223
Singer M, Brealey D (1999) Mitochondrial dysfunction in sepsis. Biochem Soc Symp 66:149–166
Vanhorebeek I, De Vos R, Mesotten D, Wouters PJ, De Wolf-Peeters C, Van den Berghe G (2005) Protection of hepatocyte mitochondrial ultrastructure and function by strict blood glucose control with insulin in critically ill patients. Lancet 365:53–59
Beltran B, Mathur A, Duchen MR, Erusalimsky JD, Moncada S (2000) The effect of nitric oxide on cell respiration: A key to understanding its role in cell survival or death. Proc Natl Acad Sci USA 97:14602–14607
Annane D, Sebille V, Troche G, Raphael JC, Gajdos P, Bellissant E (2000) A 3-level prognostic classification in septic shock based on cortisol levels and cortisol response to corticotropin. JAMA 283:1038–1045
Bornstein SR, Licinio J, Tauchnitz R, et al (1998) Plasma leptin levels are increased in survivors of acute sepsis: associated loss of diurnal rhythm, in cortisol and leptin secretion. J Clin Endocrinol Metab 83:280–283
Joosten KF, de Kleijn ED, Westerterp M, et al (2000) Endocrine and metabolic responses in children with meningoccocal sepsis: striking differences between survivors and nonsurvivors. J Clin Endocrinol Metab 85:3746–3753
Rivers E, Nguyen B, Havstad S, et al (2001) Early Goal-Directed Therapy Collaborative Group. Early goal-directed therapy in the treatment of severe sepsis and septic shock. N Engl J Med 345:1368–1377
Hayes MA, Timmins AC, Yau EHS, Palazzo M, Hinds CJ, Watson D (1994) Elevation of systemic oxygen delivery in the treatment of critically ill patients. N Engl J Med 330:1717–1722
Gattinoni L, Brazzi L, Pelosi P, et al (1995) A trial of goal-oriented hemodynamic therapy in critically ill patients. N Engl J Med 333:1025–1032
Noble JS, MacKirdy FN, Donaldson SI, Howie JC (2001) Renal and respiratory failure in Scottish ICUs. Anaesthesia 56:124–129
Docke WD, Randow F, Syrbe U, et al (1997) Monocyte deactivation in septic patients: restoration by IFN-gamma treatment. Nat Med 3:678–681
Van den Berghe G, de Zegher F, Bouillon R (1998) Acute and prolonged critical illness as different neuroendocrine paradigms. J Clin Endocrinol Metab 83:1827–1834
Kreymann G, Grosser S, Buggisch P, Gottschall C, Matthaei S, Greten H (1993) Oxygen consumption and resting metabolic rate in sepsis, sepsis syndrome, and septic shock. Crit Care Med 21:1012–1019
Dellinger RP, Carlet JM, Masur H, et al (2004) for the Surviving Sepsis Campaign Management Guidelines Committee. Surviving Sepsis Campaign guidelines for management of severe sepsis and septic shock. Crit Care Med 32:858–873
Cuffe MS, Califf RM, Adams KF Jr, et al (2002) Outcomes of a Prospective Trial of Intravenous Milrinone for Exacerbations of Chronic Heart Failure (OPTIME-CHF) Investigators. Short-term intravenous milrinone for acute exacerbation of chronic heart failure: a randomized controlled trial. JAMA 287:1541–1547
Cleland JG, Ghosh J, Freemantle N, et al (2004) Clinical trials update and cumulative meta-analyses from the American College of Cardiology: WATCH, SCD-HeFT, DINAMIT, CASINO, INSPIRE, STRATUS-US, RIO-Lipids and cardiac resynchronisation therapy in heart failure. Eur J Heart Fail 6:501–508
Lyte M, Freestone PPE, Neal CP, et al (2003) Stimulation of Staphylococcus epidermidis growth and biofilm formation by catecholamine inotropes. Lancet 361:130–135
Lyte M, Ernst S (1992) Catecholamine induced growth of Gram negative bacteria. Life Sci 50:203–212
Bailey AR, Burchett KR (1997) Effect of low-dose dopamine on serum concentrations of prolactin in critically ill patients. Br J Anaesth 78:97–99
Brand JM, Frohn C, Luhm J, Kirchner H, Schmucker P (2003) Early alterations in the number of circulating lymphocyte subpopulations and enhanced proinflammatory immune response during opioid-based general anesthesia. Shock 20:213–217
Helmy SA, Al-Attiyah RJ (2001) The immunomodulatory effects of prolonged intravenous infusion of propofol versus midazolam in critically ill surgical patients. Anaesthesia 56:4–8
Kelbel I, Koch T, Weber A, Schiefer HG, van Ackern K, Neuhof H (1999) Alterations of bacterial clearance induced by propofol. Acta Anaesthesiol Scand 43:71–76
Absalom A, Pledger D, Kong A (1999) Adrenocortical function in critically ill patients 24 h after a single dose of etomidate. Anaesthesia 54:861–867
Stevanato R, Momo F, Marian M, et al (2002) Effects of nitrosopropofol on mitochondrial energy-converting system. Biochem Pharmacol 64:1133–1138
Tune BM, Hsu CY (1990) The renal mitochondrial toxicity of beta-lactam antibiotics: in vitro effects of cephaloglycin and imipenem. J Am Soc Nephrol 1:815–821
Wilkie D (1977) Mitochondrial biogenesis: inhibitors of mitochondrial protein synthesis. Mol Cell Biochem 14:97–100
Rao SV, Jollis JG, Harrington RA, et al (2004) Relationship of blood transfusion and clinical outcomes in patients with acute coronary syndromes. JAMA 292:1555–1562
Hebert PC, Fergusson D, Blajchman MA, (2003) Clinical outcomes following institution of the Canadian universal leukoreduction program for red blood cell transfusions. JAMA 289:1941–1949
Ranieri VM, Suter PM, Tortorella C, et al (1999) Effect of mechanical ventilation on inflammatory mediators in patients with acute respiratory distress syndrome: a randomized controlled trial. JAMA 282:54–61
Heyland DK, Samis A (2003) Does immunonutrition in patients with sepsis do more harm than good? Intensive Care Med 29:669–671
Bertolini G, Iapichino G, Radrizzani D, et al (2003) Early enteral immunonutrition in patients with severe sepsis: results of an interim analysis of a randomized multicentre clinical trial. Intensive Care Med 29:834–840
Author information
Authors and Affiliations
Editor information
Editors and Affiliations
Rights and permissions
Copyright information
© 2006 Springer-Verlag Berlin Heidelberg
About this paper
Cite this paper
Singer, M. (2006). Improving Organ Function. In: Fink, M.P., Suter, P.M., Sibbald, W.J. (eds) Intensive Care Medicine in 10 Years. Update in Intensive Care and Emergency Medicine, vol 43. Springer, Berlin, Heidelberg. https://doi.org/10.1007/3-540-29730-8_15
Download citation
DOI: https://doi.org/10.1007/3-540-29730-8_15
Publisher Name: Springer, Berlin, Heidelberg
Print ISBN: 978-3-540-26092-9
Online ISBN: 978-3-540-29730-7
eBook Packages: MedicineMedicine (R0)