Skip to main content

Non-Rhabdomyosarcoma Soft Tissue Sarcomas

  • Chapter

Part of the book series: Pediatric Oncology ((PEDIATRICO))

This is a preview of subscription content, log in via an institution.

Buying options

Chapter
USD   29.95
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
eBook
USD   84.99
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
Softcover Book
USD   169.99
Price excludes VAT (USA)
  • Compact, lightweight edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info
Hardcover Book
USD   109.99
Price excludes VAT (USA)
  • Durable hardcover edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Purchases are for personal use only

Learn about institutional subscriptions

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

References

  • Alekhteyar KM, Leung DH, Brennan MF, Harrison LB (1996) The effect of combined external beam radiotherapy and brachytherapy on local control and wound complications in patients with high-grade soft tissue sarcomas of the extremity with positive microscopic margin. Int J Radiat Oncol Biol Phys 36(2):321–324

    Article  PubMed  CAS  Google Scholar 

  • Alektiar KM, Hu K, Anderson L, Brennan MF, Harrison LB (2000) High-dose-rate intraoperative radiation therapy (HDR-IORT) for retroperitoneal sarcomas. Int J Radiat Oncol Biol Phys 47(1):157–163

    Article  PubMed  CAS  Google Scholar 

  • Alektiar KM, Leung D, Zelefsky MJ, Brennan MF (2002) Adjuvant radiation for stage II-B soft tissue sarcoma of the extremity. J Clin Oncol 20(6):1643–1650

    Article  PubMed  Google Scholar 

  • American Joint Committee on Cancer (2002) Chapter 22. In: Greene FL, Page DL, Fleming ID, Fritz AG, Balch CM, Haller DG, Morrow M (eds) AJCC Cancer Staging Handbook Springer, New York

    Google Scholar 

  • Artandi SE, Chang S, Lee SL et al. (2000) Telomere dysfunction promotes non-reciprocal translocations and epithelial cancers in mice. Nature 406(6796):641–645

    PubMed  CAS  Google Scholar 

  • Baldini EH, Goldberg J, Jenner C et al. (1999) Long-term outcomes after function-sparing surgery without radiotherapy for soft tissue sarcoma of the extremities and trunk. J Clin Oncol 17(10):3252–3259

    PubMed  CAS  Google Scholar 

  • Biegel JA, Tan L, Zhang F, Wainwright L, Russo P, Rorke LB (2002) Alterations of the hSNF5/INI1 gene in central nervous system atypical teratoid/rhabdoid tumors and renal and extrarenal rhabdoid tumors. Clin Cancer Res 8(11):3461–3467

    PubMed  CAS  Google Scholar 

  • Brady MS, Gaynor JJ, Brennan MF (1992) Radiation-associated sarcoma of bone and soft tissue. Arch Surg 127(12):1379–1385

    PubMed  CAS  Google Scholar 

  • Brennan MF (1997) The enigma of local recurrence. The Society of Surgical Oncology. Ann Surg Oncol 4(1):1–12

    PubMed  CAS  Google Scholar 

  • Brouns F, Stas M, De Wever I (2003) Delay in diagnosis of soft tissue sarcomas. Eur J Surg Oncol 29(5):440–445

    Article  PubMed  CAS  Google Scholar 

  • Cessna MH, Zhou H, Sanger WG et al. (2002) Expression of ALK1 and p80 in inflammatory myofibroblastic tumor and its mesenchymal mimics: a study of 135 cases. Mod Pathol 15(9):931–938

    Article  PubMed  Google Scholar 

  • Coffin CM, Patel A, Perkins S, Elenitoba-Johnson KS, Perlman E, Griffin CA (2001) ALK1 and p80 expression and chromosomal rearrangements involving 2p23 in inflammatory myofibroblastic tumor. Mod Pathol 14(6):569–576

    Article  PubMed  CAS  Google Scholar 

  • Coindre JM, Pelmus M, Hostein I, Lussan C, Bui BN, Guillou L (2003) Should molecular testing be required for diagnosing synovial sarcoma? A prospective study of 204 cases. Cancer 98(12):2700–2707

    Article  PubMed  Google Scholar 

  • DeLaney TF, Spiro IJ, Suit HD et al. (2003) Neoadjuvant chemotherapy and radiotherapy for large extremity soft-tissue sarcomas. Int J Radiat Oncol Biol Phys 56(4):1117–1127

    Article  PubMed  Google Scholar 

  • Demetri GD (2002) ET-743: the US experience in sarcomas of soft tissues. Anticancer Drugs 13 Suppl 1:S7–9

    PubMed  CAS  Google Scholar 

  • Demetri GD, Elias AD (1995) Results of single-agent and combination chemotherapy for advanced soft tissue sarcomas. Implications for decision making in the clinic. Hematol Oncol Clin North Am 9(4):765–785

    CAS  Google Scholar 

  • Dich J, Zahm SH, Hanberg A, Adami HO (1997) Pesticides and cancer. Cancer Causes Control 8(3):420–443

    Article  PubMed  CAS  Google Scholar 

  • Donaldson SS, Torrey M, Link MP et al. (1998) A multidisciplinary study investigating radiotherapy in Ewing’s sarcoma: end results of POG #8346. Pediatric Oncology Group. Int J Radiat Oncol Biol Phys 42(1):125–135

    Article  PubMed  CAS  Google Scholar 

  • Duyster J, Bai RY, Morris SW (2001) Translocations involving anaplastic lymphoma kinase (ALK). Oncogene 20(40):5623–5637

    Article  PubMed  CAS  Google Scholar 

  • Eisenberg BL, Judson I (2004) Surgery and imatinib in the management of GIST: emerging approaches to adjuvant and neoadjuvant therapy. Ann Surg Oncol 11(5):465–475

    Article  PubMed  Google Scholar 

  • Elias A, Ryan L, Sulkes A, Collins J, Aisner J, Antman KH (1989) Response to mesna, doxorubicin, ifosfamide, and dacarbazine in 108 patients with metastatic or unresectable sarcoma and no prior chemotherapy. J Clin Oncol 7(9):1208–1216

    PubMed  CAS  Google Scholar 

  • Enneking WF, Spanier SS, Goodman MA (1980) A system for the surgical staging of musculoskeletal sarcoma. Clin Orthop 153:106–120

    PubMed  Google Scholar 

  • Espat NJ, Bilsky M, Lewis JJ, Leung D, Brennan MF (2002) Soft tissue sarcoma brain metastases. Prevalence in a cohort of 3829 patients. Cancer 94(10):2706–2711

    Article  PubMed  Google Scholar 

  • Falk H, Herbert J, Crowley S et al. (1981) Epidemiology of hepatic angiosarcoma in the United States: 1964-1974. Environ Health Perspect 41:107–113

    PubMed  CAS  Google Scholar 

  • Fleming JB, Cantor SB, Varma DG et al. (2001) Utility of chest computed tomography for staging in patients with T1 extremity soft tissue sarcomas. Cancer 92(4):863–868

    Article  PubMed  CAS  Google Scholar 

  • Fong Y, Coit DG, Woodruff JM, Brennan MF (1993) Lymph node metastasis from soft tissue sarcoma in adults. Analysis of data from a prospective database of 1772 sarcoma patients. Ann Surg 217(1):72–77

    PubMed  CAS  Google Scholar 

  • Frustaci S, Gherlinzoni F, De Paoli A et al. (2001) Adjuvant chemotherapy for adult soft tissue sarcomas of the extremities and girdles: results of the Italian randomized cooperative trial. J Clin Oncol 19(5):1238–1247

    PubMed  CAS  Google Scholar 

  • Gerald WL, Ladanyi M, de Alava E et al. (1998) Clinical, pathologic, and molecular spectrum of tumors associated with t(11;22)(p13;q12): desmoplastic small round-cell tumor and its variants. J Clin Oncol 16(9):3028–3036

    PubMed  CAS  Google Scholar 

  • Girard P, Spaggiari L, Baldeyrou P et al. (1997) Should the number of pulmonary metastases influence the surgical decision? Eur J Cardiothorac Surg 12(3):385–391; discussion 392

    Article  PubMed  CAS  Google Scholar 

  • Gortzak E, Azzarelli A, Buesa J et al. (2001) A randomised phase II study on neo-adjuvant chemotherapy for ‘high-risk’ adult soft-tissue sarcoma. Eur J Cancer 37(9):1096–1103

    Article  PubMed  CAS  Google Scholar 

  • Haimi M, Peretz Nahum M, Ben Arush MW (2004) Delay in diagnosis of children with cancer: a retrospective study of 315 children. Pediatr Hematol Oncol 21(1):37–48

    Article  PubMed  CAS  Google Scholar 

  • Hajdu SI, Shiu MH, Brennan MF (1988) The role of the pathologist in the management of soft tissue sarcomas. World J Surg 12(3):326–331

    Article  PubMed  CAS  Google Scholar 

  • Hanahan D, Weinberg RA (2000) The hallmarks of cancer. Cell 100(1):57–70

    Article  PubMed  CAS  Google Scholar 

  • Hawkins MM, Wilson LM et al. (1996) Radiotherapy, alkylating agents, and risk of bone cancer after childhood cancer. J Nat Cancer Inst 88(5):270–278

    PubMed  CAS  Google Scholar 

  • Heinrich MC, Corless CL, Duensing A et al. (2003) PDGFRA activating mutations in gastrointestinal stromal tumors. Science 299(5607):708–710

    Article  PubMed  CAS  Google Scholar 

  • Helman LJ, Meltzer P (2003) Mechanisms of sarcoma development. Nat Rev Cancer 3(9):685–694

    Article  PubMed  CAS  Google Scholar 

  • Heslin MJ, Lewis JJ, Woodruff JM, Brennan MF (1997) Core needle biopsy for diagnosis of extremity soft tissue sarcoma. Ann Surg Oncol 4(5):425–431

    PubMed  CAS  Google Scholar 

  • Hill DA, Riedley SE, Patel AR et al. (2003) Real-time polymerase chain reaction as an aid for the detection of SYT-SSX1 and SYT-SSX2 transcripts in fresh and archival pediatric synovial sarcoma specimens: report of 25 cases from St. Jude Children’s Research Hospital. Pediatr Dev Pathol 6(1):24–34

    Article  PubMed  CAS  Google Scholar 

  • Hirota S, Isozaki K, Moriyama Y et al. (1998) Gain-of-function mutations of c-kit in human gastrointestinal stromal tumors. Science 279(5350):577–580

    Article  PubMed  CAS  Google Scholar 

  • Hudson MM, Tyc VL, Cremer LK et al. (1998) Patient satisfaction after limb-sparing surgery and amputation for pediatric malignant bone tumors. J Pediatr Oncol Nurs 15(2):60–69; discussion 70-61

    PubMed  CAS  Google Scholar 

  • Ioannidis JP, Lau J (2003) 18F-FDG PET for the diagnosis and grading of soft-tissue sarcoma: a meta-analysis. J Nucl Med 44(5):717–724

    PubMed  Google Scholar 

  • Jager PL, Hoekstra HJ, Leeuw J, van Der Graaf WT, de Vries EG, Piers D (2000) Routine bone scintigraphy in primary staging of soft tissue sarcoma. Is it worthwhile? Cancer 89(8):1726–1731

    Article  PubMed  CAS  Google Scholar 

  • Judkins AR, Mauger J, Ht A, Rorke LB, Biegel JA (2004) Immunohistochemical analysis of hSNF5/INI1 in pediatric CNS neoplasms. Am J Surg Pathol 28(5):644–650

    PubMed  Google Scholar 

  • Kawai A, Woodruff J, Healey JH, Brennan MF, Antonescu CR, Ladanyi M (1998) SYT-SSX gene fusion as a determinant of morphology and prognosis in synovial sarcoma. N Engl J Med 338(3):153–160

    Article  PubMed  CAS  Google Scholar 

  • Kuttesch JF Jr, Wexler LH, Marcus RB et al. (1996) Second malignancies after Ewing’s sarcoma: radiation dose-dependency of secondary sarcomas. J Clin Oncol (10):2818–2825

    Google Scholar 

  • Ladanyi M, Antonescu CR, Leung DH et al. (2002) Impact of SYT-SSX fusion type on the clinical behavior of synovial sarcoma: a multi-institutional retrospective study of 243 patients. Cancer Res 62(1):135–140

    PubMed  CAS  Google Scholar 

  • Leu KM, Ostruszka LJ, Shewach D et al. (2004) Laboratory and clinical evidence of synergistic cytotoxicity of sequential treatment with gemcitabine followed by docetaxel in the treatment of sarcoma. J Clin Oncol 22(9):1706–1712

    Article  PubMed  CAS  Google Scholar 

  • Lewis JJ, Leung D, Woodruff JM, Brennan MF (1998) Retroperitoneal soft-tissue sarcoma: analysis of 500 patients treated and followed at a single institution. Ann Surg 228(3):355–365

    Article  PubMed  CAS  Google Scholar 

  • Li FP, Fraumeni JF Jr, Mulvihill JJ et al. (1988) A cancer family syndrome in twenty-four kindreds. Cancer Res 48(18):5358–5362

    PubMed  CAS  Google Scholar 

  • Li XQ, Hisaoka M, Shi DR, Zhu XZ, Hashimoto H (2004) Expression of anaplastic lymphoma kinase in soft tissue tumors: an immunohistochemical and molecular study of 249 cases. Hum Pathol 35(6):711–721

    Article  PubMed  CAS  Google Scholar 

  • Malkin D, Li FP, Strong LC et al. (1990) Germ line p53 mutations in a familial syndrome of breast cancer, sarcomas, and other neoplasms. Science 250(4985):1233–1238

    PubMed  CAS  Google Scholar 

  • Marcus KC, Grier HE, Shamberger RC et al. (1997) Childhood soft tissue sarcoma: a 20-year experience. J Pediatr 131(4):603–607

    PubMed  CAS  Google Scholar 

  • Maurer HM, Beltangady M, Gehan EA et al. (1988) The Intergroup Rhabdomyosarcoma Study-I. A final report. Cancer 61(2):209–220

    PubMed  CAS  Google Scholar 

  • McClain KL, Leach CT, Jenson HB et al. (1995) Association of Epstein-Barr virus with leiomyosarcomas in children with AIDS. N Engl J Med 332(1):12–18

    Article  PubMed  CAS  Google Scholar 

  • Meric F, Milas M, Hunt KK et al. (2000) Impact of neoadjuvant chemotherapy on postoperative morbidity in soft tissue sarcomas. J Clin Oncol 18(19):3378–3383

    PubMed  CAS  Google Scholar 

  • Miettinen M (1991) Keratin subsets in spindle cell sarcomas. Keratins are widespread but synovial sarcoma contains a distinctive keratin polypeptide pattern and desmoplakins. Am J Pathol 138(2):505–513

    PubMed  CAS  Google Scholar 

  • Miralles TG, Gosalbez F, Menendez P, Astudillo A, Torre C, Buesa J (1986) Fine needle aspiration cytology of soft-tissue lesions. Acta Cytol 30(6):671–678

    PubMed  CAS  Google Scholar 

  • Oliveira AM, Nascimento AG (2001) Grading in soft tissue tumors: principles and problems. Skeletal Radiol 30(10):543–559

    PubMed  CAS  Google Scholar 

  • O’Sullivan B, Davis AM, Turcotte R et al. (2002) Preoperative versus postoperative radiotherapy in soft-tissue sarcoma of the limbs: a randomised trial. Lancet 359(9325):2235–2241

    PubMed  Google Scholar 

  • Paganelli G, De Cicco C, Chinol M (2000) Sentinel node localization by lymphoscintigraphy: a reliable technique with widespread applications. Recent Results Cancer Res 157:121–129

    PubMed  CAS  Google Scholar 

  • Panagopoulos I, Mertens F, Isaksson M et al. (2001) Clinical impact of molecular and cytogenetic findings in synovial sarcoma. Genes Chromosomes Cancer 31(4):362–372

    Article  PubMed  CAS  Google Scholar 

  • Pappo AS, Rao BN, Jenkins JJ et al. (1999) Metastatic nonrhabdomyosarcomatous soft-tissue sarcomas in children and adolescents: the St. Jude Children’s Research Hospital experience. Med Pediatr Oncol 33(2):76–82

    Article  PubMed  CAS  Google Scholar 

  • Pappo AS, Devidas M, Jenkins J et al. (2005) Phase II trial of neoadjuvant vincristine, ifosfamide, and doxorubicin with granulocyte colony-stimulating factor support in children and adolescents with advanced-stage nonrhabdomyosarcomatous soft tissue sarcomas: a pediatric oncology group study. J Clin Oncol 23(18):4031–4038

    Article  PubMed  CAS  Google Scholar 

  • Parham DM, Webber BL, Jenkins JJ 3rd, Cantor AB, Maurer HM (1995) Nonrhabdomyosarcomatous soft tissue sarcomas of childhood: formulation of a simplified system for grading. Mod Pathol 8(7):705–710

    PubMed  CAS  Google Scholar 

  • Patel SR, Vadhan-Raj S, Burgess MA et al. (1998) Results of two consecutive trials of dose-intensive chemotherapy with doxorubicin and ifosfamide in patients with sarcomas. Am J Clin Oncol 21(3):317–321

    PubMed  CAS  Google Scholar 

  • Perry A, Kunz SN, Fuller CE et al. (2002) Differential NF1, p16, and EGFR patterns by interphase cytogenetics (FISH) in malignant peripheral nerve sheath tumor (MPNST) and morphologically similar spindle cell neoplasms. J Neuropathol Exp Neurol 61(8):702–709

    PubMed  CAS  Google Scholar 

  • Pisters PW, Leung DH, Woodruff J, Shi W, Brennan MF (1996a) Analysis of prognostic factors in 1,041 patients with localized soft tissue sarcomas of the extremities. J Clin Oncol 14(5):1679–1689

    PubMed  CAS  Google Scholar 

  • Pisters PW, Harrison LB, Leung DH, Woodruff JM, Casper ES, Brennan MF (1996b) Long-term results of a prospective randomized trial of adjuvant brachytherapy in soft tissue sarcoma. J Clin Oncol 14(3):859–868

    PubMed  CAS  Google Scholar 

  • Porter GA, Cantor SB, Ahmad SA et al. (2002) Cost-effectiveness of staging computed tomography of the chest in patients with T2 soft tissue sarcomas. Cancer 94(1):197–204

    Article  PubMed  Google Scholar 

  • Pratt CB, Maurer HM, Gieser P et al. (1998) Treatment of unresectable or metastatic pediatric soft tissue sarcomas with surgery, irradiation, and chemotherapy: a Pediatric Oncology Group study. Med Pediatr Oncol 30(4):201–209

    Article  PubMed  CAS  Google Scholar 

  • Pratt CB, Pappo AS, Gieser P et al. (1999) Role of adjuvant chemotherapy in the treatment of surgically resected pediatric nonrhabdomyosarcomatous soft tissue sarcomas: A Pediatric Oncology Group Study. J Clin Oncol 17(4):1219

    PubMed  CAS  Google Scholar 

  • Presant CA, Russell WO, Alexander RW, Fu YS (1986) Soft-tissue and bone sarcoma histopathology peer review: the frequency of disagreement in diagnosis and the need for second pathology opinions. The Southeastern Cancer Study Group experience. J Clin Oncol 4(11):1658–1661

    PubMed  CAS  Google Scholar 

  • Reichardt P (2002) High-dose chemotherapy in adult soft tissue sarcoma. Crit Rev Oncol Hematol 41(2):157–167

    PubMed  Google Scholar 

  • Ries LA, Smith MA, Gurney JG et al. (1999) Cancer incidence and survival among children and adolescents: United States SEER Program 1975-1995. NCI, SEER Program. NIH Pub. No. 99-4649. Bethesda, MD, pp 99–4649

    Google Scholar 

  • Roberts CW, Galusha SA, McMenamin ME, Fletcher CD, Orkin SH (2000) Haploinsufficiency of Snf5 (integrase interactor 1) predisposes to malignant rhabdoid tumors in mice. Proc Natl Acad Sci USA 97(25):13796–13800

    Article  PubMed  CAS  Google Scholar 

  • Rodriguez-Galindo C, Ramsey K et al. (2000) Hemangiopericytoma in children and infants. Cancer 88(1):198–204.

    Article  PubMed  CAS  Google Scholar 

  • Rosenberg SA, Tepper J, Glatstein E et al. (1982) The treatment of soft-tissue sarcomas of the extremities: prospective randomized evaluations of (1) limb-sparing surgery plus radiation therapy compared with amputation and (2) the role of adjuvant chemotherapy. Ann Surg 196(3):305–315

    PubMed  CAS  Google Scholar 

  • Rubin BP, Schuetze SM, Eary JF et al. (2002) Molecular targeting of platelet-derived growth factor B by imatinib mesylate in a patient with metastatic dermatofibrosarcoma protuberans. J Clin Oncol 20(17):3586–3591

    Article  PubMed  CAS  Google Scholar 

  • Rydholm A, Gustafson P, Rooser B et al. (1991) Limb-sparing surgery without radiotherapy based on anatomic location of soft tissue sarcoma. J Clin Oncol 9(10):1757–1765

    PubMed  CAS  Google Scholar 

  • Sandberg AA, Bridge JA (2002) Updates on the cytogenetics and molecular genetics of bone and soft tissue tumors: congenital (infantile) fibrosarcoma and mesoblastic nephroma. Cancer Genet Cytogenet 132(1):1–13

    Article  PubMed  CAS  Google Scholar 

  • Sarcoma Meta-analysis Collaboration (1997) Adjuvant chemotherapy for localised resectable soft-tissue sarcoma of adults: meta-analysis of individual data. Lancet 350(9092):1647–1654

    Google Scholar 

  • Scheel C, Schaefer KL, Jauch A et al. (2001) Alternative lengthening of telomeres is associated with chromosomal instability in osteosarcomas. Oncogene 20(29):3835–3844

    Article  PubMed  CAS  Google Scholar 

  • Sharpless NE, Ferguson DO, O’Hagan RC et al. (2001) Impaired nonhomologous end-joining provokes soft tissue sarcomas harboring chromosomal translocations, amplifications, and deletions. Mol Cell 8(6):1187–1196

    Article  PubMed  CAS  Google Scholar 

  • Shiraki M, Enterline HT, Brooks JJ et al. (1989) Pathologic analysis of advanced adult soft tissue sarcomas, bone sarcomas, and mesotheliomas. The Eastern Cooperative Oncology Group (ECOG) experience. Cancer 64(2):484–490

    PubMed  CAS  Google Scholar 

  • Skapek SX, Chui CH (2000) Cytogenetics and the biologic basis of sarcomas. Curr Opin Oncol 12(4):315–322

    Article  PubMed  CAS  Google Scholar 

  • Skotheim RI, Kallioniemi A, Bjerkhagen B et al. (2003) Topoisomerase-II alpha is upregulated in malignant peripheral nerve sheath tumors and associated with clinical outcome. J Clin Oncol 21(24):4586–4591

    Article  PubMed  CAS  Google Scholar 

  • Sorensen SA, Mulvihill JJ, Nielsen A (1986) Long-term follow-up of von Recklinghausen neurofibromatosis. Survival and malignant neoplasms. N Engl J Med 314(16):1010–1015

    Article  PubMed  CAS  Google Scholar 

  • Spunt SA, Poquette CA, Hurt YS et al. (1999) Prognostic factors for children and adolescents with surgically resected nonrhabdomyosarcoma soft tissue sarcoma: an analysis of 121 patients treated at St Jude Children’s Research Hospital. J Clin Oncol 17(12):3697–3705

    PubMed  CAS  Google Scholar 

  • Spunt SL, Hill DA, Motosue AM et al. (2002) Clinical features and outcome of initially unresected nonmetastatic pediatric nonrhabdomyosarcoma soft tissue sarcoma. J Clin Oncol 20(15):3225–3235

    Article  PubMed  Google Scholar 

  • Stewart FW, Treves N (1981) Classics in oncology: lymphangiosarcoma in postmastectomy lymphedema: a report of six cases in elephantiasis chirurgica. CA Cancer J Clin 31(5):284–299

    Article  PubMed  CAS  Google Scholar 

  • Stojadinovic A, Jaques DP, Leung DH, Healey JH, Brennan MF (2001) Amputation for recurrent soft tissue sarcoma of the extremity: indications and outcome. Ann Surg Oncol 8(6):509–518

    PubMed  CAS  Google Scholar 

  • Storlazzi CT, Mertens F, Mandahl N et al. (2003) A novel fusion gene, SS18L1/SSX1, in synovial sarcoma. Genes Chromosomes Cancer 37(2):195–200

    Article  PubMed  CAS  Google Scholar 

  • Tornkvist M, Brodin B, Bartolazzi A, Larsson O (2002) A novel type of SYT/SSX fusion: methodological and biological implications. Mod Pathol 15(6):679–685

    PubMed  Google Scholar 

  • Versteege I, Sevenet N, Lange J et al. (1998) Truncating mutations of hSNF5/INI1 in aggressive paediatric cancer. Nature 394(6689):203–206

    PubMed  CAS  Google Scholar 

  • Weiser MR, Downey RJ, Leung DH, Brennan MF (2000) Repeat resection of pulmonary metastases in patients with soft-tissue sarcoma. J Am Coll Surg 191(2):184–190; discussion 190-181

    PubMed  CAS  Google Scholar 

  • Wodowski K, Hill DA, Pappo AS, Shochat SJ, Kun LE, Spunt SL (2003) A chemosensitive pediatric extraosseous osteosarcoma: case report and review of the literature. J Pediatr Hematol Oncol 25(1):73–77

    Article  PubMed  Google Scholar 

  • Wong FL, Boice JD Jr, Abramson DH et al. (1997) Cancer incidence after retinoblastoma. Radiation dose and sarcoma risk. JAMA 278(15):1262–1267

    Article  PubMed  CAS  Google Scholar 

  • Wunder JS, Healey JH, Davis AM, Brennan MF (2000) A comparison of staging systems for localized extremity soft tissue sarcoma. Cancer 88(12):2721–2730

    Article  PubMed  CAS  Google Scholar 

  • Yamamoto H, Oda Y, Kawaguchi K et al. (2004) c-kit and PDGFRA mutations in extragastrointestinal stromal tumor (gastrointestinal stromal tumor of the soft tissue). Am J Surg Pathol 28(4):479–488

    PubMed  Google Scholar 

  • Yan H, Marchettini P, Acherman YI, Gething SA, Brun E, Sugarbaker PH (2003) Prognostic assessment of gastrointestinal stromal tumor. Am J Clin Oncol 26(3):221–228

    Article  PubMed  Google Scholar 

  • Yang JC, Chang AE, Baker AR et al. (1998) Randomized prospective study of the benefit of adjuvant radiation therapy in the treatment of soft tissue sarcomas of the extremity. J Clin Oncol 16(1):197–203

    PubMed  CAS  Google Scholar 

  • Zhou H, Coffin CM, Perkins SL, Tripp SR, Liew M, Viskochil DH (2003) Malignant peripheral nerve sheath tumor: a comparison of grade, immunophenotype, and cell cycle/growth activation marker expression in sporadic and neurofibromatosis 1-related lesions. Am J Surg Pathol 27(10):1337–1345

    PubMed  Google Scholar 

Download references

Author information

Authors and Affiliations

Authors

Editor information

Editors and Affiliations

Rights and permissions

Reprints and permissions

Copyright information

© 2006 Springer-Verlag Berlin Heidelberg

About this chapter

Cite this chapter

Spunt, S.L., Wolden, S.L., Schofield, D., Skapek, S.X. (2006). Non-Rhabdomyosarcoma Soft Tissue Sarcomas. In: Pappo, A. (eds) Pediatric Bone and Soft Tissue Sarcomas. Pediatric Oncology. Springer, Berlin, Heidelberg. https://doi.org/10.1007/3-540-29447-3_7

Download citation

  • DOI: https://doi.org/10.1007/3-540-29447-3_7

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-540-40843-7

  • Online ISBN: 978-3-540-29447-4

  • eBook Packages: MedicineMedicine (R0)

Publish with us

Policies and ethics