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Host Receptors in Malaria Merozoite Invasion

  • Chapter
Malaria: Drugs, Disease and Post-genomic Biology

Part of the book series: Current Topics in Microbiology and Immunology ((CT MICROBIOLOGY,volume 295))

Abstract

The clinical manifestations of Plasmodium falciparum malaria are directly linked to the blood stage of the parasite life cycle. At the blood stage, the circulating merozoites invade erythrocytes via a specific invasion pathway often identified with its dependence or independence on sialic acid residues of the host receptor. The invasion process involves multiple receptor-ligand interactions that mediate a complex series of events in a period of approximately 1 min. Although the mechanism by which merozoites invade erythrocytes is not fully understood, recent advances have put a new perspective on the importance of developing a multivalent blood stage-malaria vaccine. In this review, we highlight the role of currently identified host invasion receptors in blood-stage malaria. cr]2005|Springer-Verlag Berlin Heidelberg

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Authors and Affiliations

  1. Division of Cell Biology, Caritas St. Elizabeth’s Medical Center, Tufts University School of Medicine, 736 Cambridge Street, Boston, MA, 02135, USA

    S. S. Oh

  2. Department of Pharmacology, UIC Cancer Center, University of Illinois College of Medicine, Molecular Biology Research Building, 900 South Ashland Avenue, Chicago, IL, 60607, USA

    A. H. Chishti

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  1. Bloomberg School of Public Health, Department of Molecular Microbiology and Immunology, The Johns Hopkins University, 615 North Wolfe Street, E5628, Baltimore, MD, 21205, USA

    David J. Sullivan M.D.

  2. Department of Cellular and Molecular Medicine, Infectious Diseases Group, St. George’s Hospital Medical School, Cranmer Terrace, London, SW17 ORE, UK

    Sanjeev Krishna D. Phil, F.R.C.P., F. MED. Sci.

  3. Atlanta, Georgia

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Oh, S.S., Chishti, A.H. (2005). Host Receptors in Malaria Merozoite Invasion. In: Compans, R.W., et al. Malaria: Drugs, Disease and Post-genomic Biology. Current Topics in Microbiology and Immunology, vol 295. Springer, Berlin, Heidelberg. https://doi.org/10.1007/3-540-29088-5_8

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