Plasmodium Ookinete Invasion of the Mosquito Midgut

  • J. M. Vinetz
Part of the Current Topics in Microbiology and Immunology book series (CT MICROBIOLOGY, volume 295)


The Plasmodium ookinete is the developmental stage of the malaria parasite that invades the mosquito midgut. The ookinete faces two physical barriers in the midgut which it must traverse to become an oocyst: the chitin- and protein-containing peritrophic matrix; and the midgut epithelial cell. This chapter will consider basic aspects of ookinete biology, molecules known to be involved in midgut invasion, and cellular processes of the ookinete that facilitate parasite invasion. Detailed knowledge of these mechanisms may be exploitable in the future towards developing novel strategies of blocking malaria transmission.


Peritrophic Membrane Parasite Invasion Mosquito Midgut Peritrophic Matrix Midgut Epithelial Cell 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


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Copyright information

© Springer-Verlag Berlin Heidelberg 2005

Authors and Affiliations

  • J. M. Vinetz
    • 1
  1. 1.Division of Infectious DiseasesUniversity of California, San Diego School of MedicineUSA

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