Conclusion
So far a number of rare genetic variations of VKORC1 have been found to contribute to a broad range of coumarin requirement. It would be of interest, whether future studies may also discover more common haplotypes of the VKORC1 gene that affect coumarin dosing. Such studies will be helpful to understand the anticoagulant response to coumarin derivatives and may improve the safe and effective use by better tailoring of dosage with an individual’s genetic variation. Moreover, novel anticoagulant drugs may be developed based on the knowledge of the structure of VKORC1 and the resulting multiprotein complex.
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Geisen, C. et al. (2006). A Novel Mutation (Asp36Tyr) in the Vitamin K Epoxide Reductase Complex Subunit 1 Gene (VKORC1) Causes Increased Phenprocoumon Requirement. In: Scharrer, I., Schramm, W. (eds) 35th Hemophilia Symposium. Springer, Berlin, Heidelberg. https://doi.org/10.1007/3-540-28546-6_47
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