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References
Abeytunga DTU, Glick JJ, Gibson NJ, Oland LA, Somogyi A, Wysocki VH, Polt R (2004) Presence of unsaturated sphingomyelins and changes in their composition during the life cycle of the moth Manduca sexta. J Lipid Res 45:1221–1231
Aloia, RC, Tian H, Jensen FC (1993) Lipid composition and fluidity of the human immunodeficiency virus envelope and host cell plasma membranes. Proc Natl Acad Sci USA 90:5181–5185
Anderson, RG (1998) The caveolae membrane system. Annu Rev Biochem 67:199–225
Antes P, Schwarzmann G, Sandhoff K (1992) Detection of protein mediated glycosphingolipid clustering by the use of resonance energy transfer between fluorescent labelled lipids A method established by applying the system ganglioside GM1 and cholera toxin B subunit. Chem Phys Lipids 62:269–280
Arbuzova A, Wang L, Wang J, Hangyas-Mihalyne G, Murray D, Honig B, McLaughlin S (2000) Membrane binding of peptides containing both basic and aromatic residues Experimental studies with peptides corresponding to the scaffolding region of caveolin and the effector region of MARCKS. Biochemistry 39:10330–10339
Bacia K, Scherfeld D, Kahya N, Schwille P (2004) Fluorescence correlation spectroscopy relates rafts in model and native membranes. Biophys J 87:1034–1043
Brown DA and London E (2000) Structure and function of sphingolipid-and cholesterol-rich membrane rafts. J Biol Chem 275:17221–17224
Brzustowicz MR, Cherezov V, Caffrey M, Stillwell W, Wassall SR (2002a) Molecular organization of cholesterol in polyunsaturated membranes: microdomain formation. Biophys J 82:285–298
Brzustowicz MR, Cherezov V, Zerouga M, Caffrey M, Stillwell W, Wassall SR (2002b) Controlling membrane cholesterol content a role for polyunsaturated (docosahexaenoate) phospholipids. Biochemistry 41:12509–12519
Caroni P (2001) New EMBO members’ review: actin cytoskeleton regulation through modulation of PI(4, 5)P(2) rafts. EMBO J 20:4332–4336
Cristian L, Lear JD, DeGrado WF (2003) Use of thiol-disulfide equilibria to measure the energetics of assembly of transmembrane helices in phospholipid bilayers. Proc Natl Acad Sci USA 100:14772–14777
de Almeida RF, Fedorov A, Prieto M (2003) Sphingomyelin/phosphatidylcholine/cholesterol phase diagram: boundaries and composition of lipid rafts. Biophys J 85:2406–2416
Denisov G, Wanaski S, Luan P, Glaser M, McLaughlin S (1998) Binding of basic peptides to membranes produces lateral domains enriched in the acidic lipids phosphatidylserine and phosphatidylinositol 4, 5-bisphosphate: an electrostatic model and experimental results. Biophys J 74:731–744
Dietzen DJ, Hastings WR, Lublin DM (1995) Caveolin is palmitoylated on multiple cysteine residues Palmitoylation is not necessary for localization of caveolin to caveolae. J Biol Chem 270:6838–6842
Ellena JF, Moulthrop J, Wu J, Rauch M, Jaysinghne S, Castle JD, Cafiso DS (2004) Membrane position of a basic aromatic peptide that sequesters phosphatidylinositol 4, 5 bisphosphate determined by site-directed spin labeling and high-resolution NMR. Biophys J 87:3221–3233
Epand RF, Sayer BG, Epand RM (2005a) The tryptophan-rich region of HIV gp41 and the promotion of cholesterol-rich domains. Biochemistry 44:5525–5531
Epand RM, Rychnovsky S, Belani J, Epand RF (2005b) Role of chirality in peptide-induced formation of cholesterol-rich domains. Biochemical J 390:541–548
Epand RM, Epand RF (2004) Non-raft forming sphingomyelin-cholesterol mixtures. Chem Phys Lipids 132:37–46
Epand RM, Maekawa S, Yip CM, Epand RF (2001) Protein-induced formation of cholesterol-rich domains. Biochemistry 40:10514–10521
Epand RM, Sayer BG, Epand RF (2003) Peptide-induced formation of cholesterol-rich domains. Biochemistry 42:14677–14689
Epand RM, Sayer BG, Epand RF (2005c) Caveolin scaffolding region and cholesterol-rich domains in membranes. J Mol Biol 345:339–350
Epand RM, Vuong P, Yip CM, Maekawa S, Epand RF (2004) Cholesterol-dependent partitioning of Ptdlns(4,5)P-2 into membrane domains by the N-terminal fragment of NAP-22 (neuronal axonal myristoylated membrane protein of 22 kDa). Biochemical Journal 379:527–532
Esser MT, Graham DR, Coren LV, Trubey CM, Bess JW, Jr, Arthur LO, Ott DE, Lifson JD (2001) Differential incorporation of CD45, CD80 (B7-1), CD86 (B7-2), major histocompatibility complex class I and II molecules into human immunodeficiency virus type 1 virions and microvesicles: implications for viral pathogenesis and immune regulation. J Virol 75:6173–6182
Gambhir A, Hangyas-Mihalyne G, Zaitseva I, Cafiso DS, Wang J, Murray D, Pentyala SN, Smith SO, McLaughlin S (2004) Electrostatic sequestration of PIP2 on phospholipid membranes by basic/aromatic regions of proteins. Biophys J 86:2188–2207
Graham DR, Chertova E, Hilburn JM, Arthur LO, Hildreth JE (2003) Cholesterol depletion of human immunodeficiency virus type 1 and simian immunodeficiency virus with beta-cyclodextrin inactivates and permeabilizes the virions: evidence for virion-associated lipid rafts. J Virol 77:8237–8248
Huang J and Feigenson GW (1993) Monte Carlo simulation of lipid mixtures: finding phase separation. Biophys J 65:1788–1794
Huang J, Swanson JE, Dibble AR, Hinderliter AK, Feigenson GW (1993) Nonideal mixing of phosphatidylserine and phosphatidylcholine in the fluid lamellar phase. Biophys J 64:413–425
Hurley JH and Meyer T (2001) Subcellular targeting by membrane lipids. Curr Opin Cell Biol 13:146–152
Ishitsuka R, Yamaji-Hasegawa A, Makino A, Hirabayashi Y, Kobayashi T (2004) A lipid-specific toxin reveals heterogeneity of sphingomyelin-containing membranes. Biophys J 86:296–307
Janmey PA and Stossel TP 1987 Modulation of gelsolin function by phosphatidylinositol 4, 5-bisphosphate. Nature 325:362–364
Karatekin E, Sandre O, Guitouni H, Borghi N, Puech PH, Brochard-Wyart F (2003) Cascades of transient pores in giant vesicles: line tension and transport. Biophys J 84:1734–1749
Kenworthy AK, Petranova N, Edidin M (2000) High-resolution FRET microscopy of cholera toxin B-subunit and GPI-anchored proteins in cell plasma membranes. Mol Biol Cell 11:1645–1655
Khan TK, Yang B, Thompson NL, Maekawa S, Epand RM, Jacobson K (2003) Binding of NAP-22, a calmodulin-binding neuronal protein, to raft-like domains in model membranes. Biochemistry 42:4780–4786
Klopfenstein DR, Tomishige M, Stuurman N, Vale RD (2002) Role of phosphatidylinositol(4, 5)bisphosphate organization in membrane transport by the Unc104 kinesin motor. Cell 109:347–358
Lalitha S, Kumar AS, Stine KJ, Covey DF (2001a) Chirality in membranes: first evidence that enantioselective interactions between cholesterol and cell membrane lipids can be a determinant of membrane physical properties. J Supramol Chem 1:53–61
Lalitha S, Kumar AS, Stine KJ, Covey DF (2001b) Enantiospecificity of sterol-lipid interactions: first evidence that the absolute configuration of cholesterol affects the physical properties of cholesterol-sphingomyelin membranes. Chem Commun 1192–1193
Lanne B, Schierbeck B, Angstrom J (1999) Binding of cholera toxin B-subunits to derivatives of the natural ganglioside receptor, GM1. J Biochem (Tokyo) 126:226–234
Laux T, Fukami K, Thelen M, Golub T, Frey D, Caroni P (2000) GAP43, MARCKS, and CAP23 modulate PI(4, 5)P(2) at plasmalemmal rafts, and regulate cell cortex actin dynamics through a common mechanism. J Cell Biol 149:1455–1472
Li H, Papadopoulos V (1998) Peripheral-type benzodiazepine receptor function in cholesterol transport Identification of a putative cholesterol recognition/interaction amino acid sequence and consensus pattern. Endocrinology 139:4991–4997
Li H, Yao Z, Degenhardt B, Teper G, Papadopoulos V (2001) Cholesterol binding at the cholesterol recognition/ interaction amino acid consensus (CRAC) of the peripheral-type benzodiazepine receptor and inhibition of steroidogenesis by an HIV TAT-CRAC peptide. Proc Natl Acad Sci USA 98:1267–1272
Liu Y, Casey L, Pike LJ (1998) Compartmentalization of phosphatidylinositol 4,5-bisphosphate in low-density membrane domains in the absence of caveolin. Biochem Biophys Res Commun 245:684–690
Maekawa S, Sato C, Kitajima K, Funatsu N, Kumanogoh H, Sokawa Y (1999) Cholesterol-dependent localization of NAP-22 on a neuronal membrane microdomain (raft). J Biol Chem 274:21369–21374
Mattjus P, Slotte JP (1996) Does cholesterol discriminate between sphingomyelin and phosphatidylcholine in mixed monolayers containing both phospholipids? Chem Phys Lipids 81:69–80
McIntosh TJ (2004) The (2004) Biophysical Society — Avanti Award in Lipids address: roles of bilayer structure and elastic properties in peptide localization in membranes. Chem Phys Lipids 130:83–98
McIntosh TJ, Vidal A, Simon SA (2003) Sorting of lipids and transmembrane peptides between detergent-soluble bilayers and detergent-resistant rafts. Biophys J 85:1656–1666
McLaughlin S, Wang J, Gambhir A, Murray D (2002) PIP(2) and proteins: interactions, organization, and information flow. Annu Rev Biophys Biomol Struct 31:151–175
Melkonian KA, Ostermeyer AG, Chen JZ, Roth MG, Brown DA (1999) Role of lipid modifications in targeting proteins to detergent-resistant membrane rafts Many raft proteins are acylated, while few are prenylated. J Biol Chem 274:3910–3917
Metso AJ, Mattila JP, Kinnunen PK (2004) Characterization of the main transition of dinervonoylphosphocholine liposomes by fluorescence spectroscopy. Biochim Biophys Acta 1663:222–231
Milhiet PE, Giocondi MC, Le Grimellec C (2002) Cholesterol is not crucial for the existence of microdomains in kidney brush-border membrane models. J Biol Chem 277:875–878
Misra S, Miller GJ, Hurley JH (2001) Recognizing phosphatidylinositol 3-phosphate. Cell 107:559–562
Mitchell JS, Kanca O, McIntyre BW (2002) Lipid microdomain clustering induces a redistribution of antigen recognition and adhesion molecules on human T lymphocytes. J Immunol 168:2737–2744
Morandat S, Bortolato M, Roux B (2002) Cholesterol-dependent insertion of glycosylphosphatidylinositol-anchored enzyme. Biochim Biophys Acta 1564:473–478
Munro S (2003) Lipid rafts: elusive or illusive? Cell 115:377–388
Nagy P, Vereb G, Sebestyen Z, Horvath G, Lockett SJ, Damjanovich S, Park JW, Jovin TM, Szollosi J (2002) Lipid rafts and the local density of ErbB proteins influence the biological role of homo-and heteroassociations of ErbB2. J Cell Sci 115:4251–4262
Nguyen DH, Hildreth JE (2000) Evidence for budding of human immunodeficiency virus type 1 selectively from glycolipid-enriched membrane lipid rafts. J Virol 74:3264–3272
Parmryd I, Adler J, Patel R, Magee AI (2003) Imaging metabolism of phosphatidylinositol 4,5-bisphosphate in T-cell GM1-enriched domains containing Ras proteins. Exp Cell Res 285:27–38
Pike LJ, Casey L (1996) Localization and turnover of phosphatidylinositol 4,5-bisphosphate in caveolin-enriched membrane domains. J Biol Chem 271:26453–26456
Ramachandran R, Heuck AP, Tweten RK, Johnson AE (2002) Structural insights into the membrane-anchoring mechanism of a cholesterol-dependent cytolysin. Nat Struct Biol 9:823–827
Ren J, Lew S, Wang Z, London E (1997) Transmembrane orientation of hydrophobic alphahelices is regulated both by the relationship of helix length to bilayer thickness and by the cholesterol concentration. Biochemistry 36:10213–10220
Resh MD (2004) Membrane targeting of lipid modified signal transduction proteins. Subcell Biochem 37:217–232
Rozelle AL, Machesky LM, Yamamoto M, Driessens MH, Insall RH, Roth MG, Luby-Phelps K, Marriott G, Hall A, Yin HL (2000) Phosphatidylinositol 4,5-bisphosphate induces actinbased movement of raft-enriched vesicles through WASP-Arp2/3. Curr Biol 10:311–320
Saez-Cirion A, Arrondo JL, Gomara MJ, Lorizate M, Iloro I, Melikyan G, Nieva JL (2003) Structural and functional roles of HIV-1 gp41 pretransmembrane sequence segmentation. Biophys J 85:3769–3780
Saez-Cirion A, Nir S, Lorizate M, Agirre A, Cruz A, Perez-Gil J, Nieva JL (2002) Sphingomyelin and cholesterol promote HIV-1 gp41 pretransmembrane sequence surface aggregation and membrane restructuring. J Biol Chem 277:21776–21785
Sakurai N, Kaneko J, Kamio Y, Tomita T (2004) Cloning, expression, and pore-forming properties of mature and precursor forms of pleurotolysin, a sphingomyelin-specific two-component cytolysin from the edible mushroom Pleurotus ostreatus. Biochim Biophys Acta 1679:65–73
Salzwedel K, West JT, Hunter E (1999) A conserved tryptophan-rich motif in the membrane-proximal region of the human immunodeficiency virus type 1 gp41 ectodomain is important for Env-mediated fusion and virus infectivity. J Virol 73:2469–2480
Schlegel A, Schwab RB, Scherer PE, Lisanti MP (1999) A role for the caveolin scaffolding domain in mediating the membrane attachment of caveolin-1 The caveolin scaffolding domain is both necessary and sufficient for membrane binding in vitro. J Biol Chem 274:22660–22667
Sepcic K, Berne S, Rebolj K, Batista UK, Plemenitas A, Sentjurc M, Macek P (2004) Ostreolysin, a pore-forming protein from the oyster mushroom, interacts specifically with membrane cholesterol-rich lipid domains. FEBS Lett 575:81–85
Shakor ABA, Czurylo EA, Sobota A (2003) Lysenin, a unique sphingomyelin-binding protein. FEBS Lett 542:1–6
Sharma P, Varma R, Sarasij RC, Ira, Gousset K, Krishnamoorthy G, Rao M, Mayor S (2004) Nanoscale organization of multiple GPI-anchored proteins in living cell membranes. Cell 116:577–589
Sharom FJ, Lehto MT (2002) Glycosylphosphatidylinositol-anchored proteins: structure, function, and cleavage by phosphatidylinositol-specific phospholipase C. Biochem Cell Biol 80:535–549
Shimada Y, Maruya M, Iwashita S, Ohno-Iwashita Y (2002) The C-terminal domain of perfringolysin O is an essential cholesterol-binding unit targeting to cholesterol-rich microdomains. Eur J Biochem 269:6195–6203
Shnaper S, Sackett K, Gallo SA, Blumenthal R, Shai Y (2004) The C-and the N-terminal regions of glycoprotein 41 ectodomain fuse membranes enriched and not enriched with cholesterol, respectively. J Biol Chem 279:18526–18534
Terashita A, Funatsu N, Umeda M, Shimada Y, Ohno-Iwashita Y, Epand RM, Maekawa S (2002) Lipid binding activity of a neuron-specific protein NAP-22 studied in vivo and in vitro. J Neurosci Res 70:172–179
Tomita T, Noguchi K, Mimuro H, Ukaji F, Ito K, Sugawara-Tomita N, Hashimoto Y (2004) Pleurotolysin, a novel sphingomyelin-specific two-component cytolysin from the edible mushroom Pleurotus ostreatus, assembles into a transmembrane pore complex. J Biol Chem 279:26975–26982
Veatch SL, Keller SL (2002) Organization in lipid membranes containing cholesterol. Phys Rev Lett 89:268101
Veatch SL, Keller SL (2003) A closer look at the canonical ‘raft mixture’ in model membrane studies. Biophys J 84:725–726
Veatch SL, Polozov IV, Gawrisch K, Keller SL (2004) Liquid domains in vesicles investigated by NMR and fluorescence microscopy. Biophys J 86:2910–2922
Viard M, Parolini I, Rawat SS, Fecchi K, Sargiacomo M, Puri A, Blumenthal R (2004) The role of glycosphingolipids in HIV signaling, entry and pathogenesis. Glycoconj J 20:213–222
Viard M, Parolini I, Sargiacomo M, Fecchi K, Ramoni C, Ablan S, Ruscetti FW, Wang JM, Blumenthal R (2002) Role of cholesterol in human immunodeficiency virus type 1 envelope protein-mediated fusion with host cells. J Virol 76:11584–11595
Vincent N, Genin C, Malvoisin E (2002) Identification of a conserved domain of the HIV-1 transmembrane protein gp41 which interacts with cholesteryl groups. Biochim Biophys Acta 1567:157–164
Waarts BL, Bittman R, Wilschut J (2002) Sphingolipid and cholesterol dependence of alphavirus membrane fusion Lack of correlation with lipid raft formation in target liposomes. J Biol Chem 277:38141–38147
Waheed AA, Shimada Y, Heijnen HF, Nakamura M, Inomata M, Hayashi M, Iwashita S, Slot JW, Ohno-Iwashita Y (2001) Selective binding of perfringolysin O derivative to cholesterolrich membrane microdomains (rafts). Proc Natl Acad Sci USA 98:4926–4931
Wanaski SP, Ng BK, Glaser M (2003) Caveolin scaffolding region and the membrane binding region of SRC form lateral membrane domains. Biochemistry 42:42–56
Wang J, Gunning W, Kelley KM, Ratnam M (2002) Evidence for segregation of heterologous GPI-anchored proteins into separate lipid rafts within the plasma membrane. J Membr Biol 189:35–43
Widmer F, Caroni P (1990) Identification, localization, and primary structure of CAP-23, a particle-bound cytosolic protein of early development. J Cell Biol 111:3035–3047
Woodman SE, Schlegel A, Cohen AW, Lisanti MP (2002) Mutational analysis identifies a short atypical membrane attachment sequence (KYWFYR) within caveolin-1. Biochemistry 41:3790–3795
Yamaji-Hasegawa A, Makino A, Baba T, Senoh Y, Kimura-Suda H, Sato SB, Terada N, Ohno S, Kiyokawa E, Umeda M, Kobayashi T (2003) Oligomerization and pore formation of a sphingomyelin-specific toxin, lysenin. J Biol Chem 278:22762–22770
Zhelev DV, Needham D (1993) Tension-stabilized pores in giant vesicles: determination of pore size and pore line tension. Biochim Biophys Acta 1147:89–104
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Epand, R.M. (2006). The Role of Proteins in the Formation of Domains in Membranes. In: Mateo, C.R., Gómez, J., Villalaín, J., González-Ros, J.M. (eds) Protein-Lipid Interactions. Springer Series in Biophysics, vol 9. Springer, Berlin, Heidelberg. https://doi.org/10.1007/3-540-28435-4_4
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