Polypeptide chain termination and stop codon readthrough on eukaryotic ribosomes

  • S. Rospert
  • M. Rakwalska
  • Y. Dubaquié
Part of the Reviews of Physiology, Biochemistry, and Pharmacology book series (REVIEWS, volume 155)


During protein translation, a variety of quality control checks ensure that the resulting polypeptides deviate minimally from their genetic encoding template. Translational fidelity is central in order to preserve the function and integrity of each cell. Correct termination is an important aspect of translational fidelity, and a multitude of mechanisms and players participate in this exquisitely regulated process. This review explores our current understanding of eukaryotic termination by highlighting the roles of the different ribosomal components as well as termination factors and ribosome-associated proteins, such as chaperones.


Release Factor Translation Termination Peptidyl Transferase Center Eukaryotic Ribosome Nonsense Suppression 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


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Copyright information

© Springer-Verlag 2005

Authors and Affiliations

  • S. Rospert
    • 1
  • M. Rakwalska
    • 1
  • Y. Dubaquié
    • 2
  1. 1.Institut für Biochemie und MolekularbiologieUniversität FreiburgFreiburgGermany
  2. 2.Bristol-Myers Squibb Medical ImagingNorth BillericaUSA

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