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Learning and Memory

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Anxiety and Anxiolytic Drugs

Part of the book series: Handbook of Experimental Pharmacology ((HEP,volume 169))

Abstract

Learning and memory processes are thought to underlie a variety of human psychiatric disorders, including generalised anxiety disorder and post-traumatic stress disorder. Basic research performed in laboratory animals may help to elucidate the aetiology of the respective diseases. This chapter gives a short introduction into theoretical and practical aspects of animal experiments aimed at investigating acquisition, consolidation and extinction of aversive memories. It describes the behavioural paradigms most commonly used as well as neuroanatomical, cellular and molecular correlates of aversive memories. Finally, it discusses clinical implications of the results obtained in animal experiments in respect to the development of novel pharmacotherapeutic strategies for the treatment of human patients.

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  1. Research Group Neuronal Plasticity/Mouse Behaviour, Max-Planck-Institute of Psychiatry, Kraepelinstr. 2-10, 80804, Munich, Germany

    C.T. Wotjak

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  1. Max-Planck-Institut für Psychiatrie, Kraepelinstr. 10, 80804, München, Germany

    Florian Holsboer

  2. Klinik für Psychiatrie und Psychotherapie, Charité Campus Mitte, Charité — Universitätsmedizin Berlin, Schuhmannstr. 20/21, 10117, Berlin, Germany

    Andreas Ströhle

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Wotjak, C. (2005). Learning and Memory. In: Holsboer, F., Ströhle, A. (eds) Anxiety and Anxiolytic Drugs. Handbook of Experimental Pharmacology, vol 169. Springer, Berlin, Heidelberg. https://doi.org/10.1007/3-540-28082-0_1

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