Absorbance-Based Integrated Optical Sensors

  • Mar Puyol
  • Francisco Villuendas
  • Carlos Domínguez
  • Víctor Cadarso
  • Andreu Llobera
  • Iñigo Salinas
  • Ignacio Garcés
  • Julián Alonso
Part of the Springer Series on Chemical Sensors and Biosensors book series (SSSENSORS, volume 3)


Optochemical sensors have had a huge expansion and in recent years interesting sorts of optical sensor have been developed which make use of the integrated circuit microelectronic technology and the optical technological advances achieved in the telecommunications industry. These devices are based on optical fibers, planar waveguides or the combination of both supports as light-guiding structures and offer an enhanced performance thanks to a miniaturized size, a feasible mass production at low cost, the possibility to measure at large distances and the capability of reaching places hard to access for the in situ monitoring of environmental or medical parameters. In this chapter, we provide an overall view of integrated chemical sensors based on absorbance measurements, describing their main characteristics, advantages and drawbacks. In order to focus on these types of devices, first of all, a brief classification is given, in terms of the interaction mechanisms and the reactive phases or membranes that are involved in the response, and the radiation transmission medium. Next, different waveguide configurations are briefly described because of to the relevancy of these structures as the main constituent of integrated optodes and, finally, some absorbance-based integrated sensors are detailed.


Absorbance Antiresonant reflecting optical waveguide Core-based optodes Integration Ion-selective optodes 


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  1. 1.
    Capitán-Vallvey LF, Fernández Ramos MD, Al-Natsheh M (2003) Sens Actuators B 88:217Google Scholar
  2. 2.
    Schult K, Katerkamp A, Trau D, Grawe F, Cammann K, Meusel M (1999) Anal Chem 71:5430CrossRefGoogle Scholar
  3. 3.
    Boisdé G, Harmer A (1995) Chemical and biochemical sensing with optical fibers and waveguides (eds) Artech House, LondonGoogle Scholar
  4. 4. Scholar
  5. 5. Scholar
  6. 6.
    Orellana G, García-Fresnadillo D (2004) In: Narayanaswamy R, Wolfbeis OS (eds) Springer series on chemical sensors and biosensors, vol 1, chap 13. Springer, Berlin Heidelberg New YorkGoogle Scholar
  7. 7.
    Patonay G, Casay GA, Lipowska M, Strekowski L (1993) Talanta 40:935CrossRefGoogle Scholar
  8. 8.
    Bakker E, Lerchi M, Rosatzin T, Rusterholz B, Simon W (1993) Anal Chim Acta 278:211CrossRefGoogle Scholar
  9. 9.
    Lindauer H, Czerney P, Mohr GJ, Grummt UW (1994) Dyes Pigments 26:229CrossRefGoogle Scholar
  10. 10.
    Kuznetsov VV, Yakunina IV (1995) Mendeleev Commun 52Google Scholar
  11. 11.
    Citterio D, Rásonyi S, Spichiger UE (1996) Fresenius J Anal Chem 354:836Google Scholar
  12. 12.
    Lobnik A, Oehme I, Murkovic I, Wolfbeis OS (1998) Anal Chim Acta 367:159CrossRefGoogle Scholar
  13. 13.
    Delmarre D, Méallet-Renault R, Bied-Charreton C, Pasternack RF (1999) Anal Chim Acta 401:125CrossRefGoogle Scholar
  14. 14.
    Wang E, Zhu L, Ma L, Patel H (1997) Anal Chim Acta 357:85CrossRefGoogle Scholar
  15. 15.
    Wallington S-A, Labayen T, Poppe A, Sommerdijk NAJM, Wright JD (1997) Sens Actuators B 38–39:48Google Scholar
  16. 16.
    Tarazi L, George A, Patonay G, Strekowski L (1998) Talanta 46:1413CrossRefGoogle Scholar
  17. 17.
    O’Neill S, Conway S, Twellmeyer J, Egan O, Nolan K, Diamond D (1999) Anal Chim Acta 398:1Google Scholar
  18. 18.
    Balogh IS, Maga IM, Hargitai-Tóth A, Andruch V (2000) Talanta 53:543CrossRefGoogle Scholar
  19. 19.
    Geddes CD, Lakowicz JR, Rosenfeld MY (2002) J Fluorescence 12:119Google Scholar
  20. 20.
    Huang HM, Wang KM, Xiao D, Yang RH, Yang XH (2001) Anal Chim Acta 439:55CrossRefGoogle Scholar
  21. 21.
    Chan WH, Yang RH, Wang KM (2001) Anal Chim Acta 444:261CrossRefGoogle Scholar
  22. 22.
    Narayanaswamy R, Brook TE (1997) Sens Actuators B 39:195Google Scholar
  23. 23.
    MacCraith BD, McDonagh CM, O’Keeffe G, Keyes ET, Vos J (1993) Analyst 118:385CrossRefGoogle Scholar
  24. 24.
    Choquette SJ, Locascio-Brown L, Durst RA (1992) Anal Chem 64:55CrossRefGoogle Scholar
  25. 25.
    Braun S, Shtelzr S, Rappoport S, Avnir D, Ottolenghi M (1992) J Non-Cryst Solids 147–148:739Google Scholar
  26. 26.
    Wu S, Ellerby LM, Cohan JS, Dunn B, El-Sayed MA, Valentine JS, Zink JI (1993) Chem Mater 5:115Google Scholar
  27. 27.
    Wang R, Narang U, Prasad PN, Bright FV (1993) Anal Chem 65:2671Google Scholar
  28. 28.
    Koncki R, Mohr GJ, Wolfbeis OS (1995) Biosens Bioelectron 10:653CrossRefGoogle Scholar
  29. 29.
    Wang Y, Robitt DR (1994) Anal Chim Acta 298:105CrossRefGoogle Scholar
  30. 30.
    Kawabata Y, Kamichika T, Imasaka T, Ishibashi N (1990) Anal Chem 62:2054Google Scholar
  31. 31.
    Zhujun Z, Seitz R (1984) Anal Chim Acta 160:47Google Scholar
  32. 32.
    Leiner MJP, Wolfbeis OS (1991) In: Wolfbeis OS (ed) Fiber optic chemical sensors and biosensors, vol 1. CRC, Graz, p 364Google Scholar
  33. 33.
    Oehme I, Prokes B, Murkovic I, Werner T, Klimant I, Wolfbeis OS (1994) Fresenius J Anal Chem 350:563Google Scholar
  34. 34.
    Suzuki K, Ohzora H, Tohda K, Miyazaki K, Watanabe K, Inoue H, Shirai T (1990) Anal Chim Acta 237:155CrossRefGoogle Scholar
  35. 35.
    Encinas, C (2003) PhD thesis, Universidad Autónoma de BarcelonaGoogle Scholar
  36. 36.
    Citterio D, Jenny L, Rásonyi S, Spichiger UE (1997) Sens Actuators B 38–39:202Google Scholar
  37. 37.
    Lehmann H, Schwotzer G, Czerney P, Mohr GJ (1995) Sens Actuators B 29:392Google Scholar
  38. 38.
    Puyol M, Miltsov S, Salinas I, Alonso J (2002) Anal Chem 74:570Google Scholar
  39. 39.
    Puyol M, Salinas I, Garcés I, Villuendas F, Llobera A, Dominguez C, Alonso J (2002) Anal Chem 74:3354Google Scholar
  40. 40.
    Freiner D, Kunz RE, Citterio D, Spichiger UE, Gale MT (1995) Sens Actuators B 29:277CrossRefGoogle Scholar
  41. 41.
    Lerchi M, Bakker E, Rusterholz B, Simon W (1992) Anal Chem 64:1534CrossRefGoogle Scholar
  42. 42.
    Preininger C, Mohr GJ (1997) Anal Chim Acta 342:207CrossRefGoogle Scholar
  43. 43.
    Demuth C, Spichiger UE (1997) Anal Chim Acta 355:259CrossRefGoogle Scholar
  44. 44.
    Citterio D, Jenny L, Spichiger UE (1998) Anal Chem 70:3452CrossRefGoogle Scholar
  45. 45.
    Malins C, Landl M, Simon P, MacCraith BD (1998) Sens Actuators B 51:359CrossRefGoogle Scholar
  46. 46.
    Kvasnik F, McGrath AD (1989) Proc SPIE Int Soc Opt Eng 172:75Google Scholar
  47. 47. Scholar
  48. 48.
    Ramo S, Whinnery JR, Van Duzer T (1994) Fields and waves in communication electronics. Wiley, New YorkGoogle Scholar
  49. 49.
    Sudbo AS (1992) J Lightwave Technol 10:418CrossRefGoogle Scholar
  50. 50.
    Snyder AW, Love DJ (1983) Optical waveguide theory. Chapman & Hall, New YorkGoogle Scholar
  51. 51.
    Okamoto W (2000) Fundamentals of optical waveguides. Academic, San DiegoGoogle Scholar
  52. 52.
    Lukosz W, Tiefenthaler W (1988) Sens Actuators B 15:273Google Scholar
  53. 53.
    Prieto F, Llobera A, Jiménez D, Domínguez C, Calle A, Lechuga LM (2000) J Lightwave Technol 18:966CrossRefGoogle Scholar
  54. 54.
    Heideman RG, Kooyman RPH, Greve J (1993) Sens Actuators B 10:209CrossRefGoogle Scholar
  55. 55.
    Luff BJ, Wilkinson JS, Piehler J, Hollenbach U, Ingenhoff J, Fabricius N (1998) J Lightwave Technol 16:583CrossRefGoogle Scholar
  56. 56.
    Veldhuis GJ, Parriaux O, Hoekstra HJWM, Lambeck PV (2000) J Lightwave Technol 18:677CrossRefGoogle Scholar
  57. 57.
    Vinchant JF, Pagnod-Rossiaux P, Le Bris J, Goutelle A, Bissessur H, Renaud M (1994) IEEE Phot Tech Lett 6:1347Google Scholar
  58. 58.
    Bayle JJ, Mateo J (1996) 5th international conference on plastic optical fibers and applications, Paris, FranceGoogle Scholar
  59. 59.
    Philip-Chandy R, Scully PJ, Eldridge P, Kadim HJ, Gérard Grapin M, Jonca MG, D’Ambrosio MG, Colin F (2000) IEEE J Quantum Elect 6:764Google Scholar
  60. 60.
    Ueberfeld J, Parthasarathy N, Zbinden H, Gisin N, Buffle J (2002) Anal Chem 74:664CrossRefGoogle Scholar
  61. 61.
    Flannery D, James SW, Tatam RP, Ashwell GJ (1997) Opt Lett 22:567Google Scholar
  62. 62.
    Weigl BH, Wolfbeis OS (1994) Anal Chem 66:3323CrossRefGoogle Scholar
  63. 63.
    Kapila D, Plawsky JL (1995) Chem Eng Sci 50:2589Google Scholar
  64. 64.
    Hunsperger RG (1995) In: Hunsperger RG (ed) Integrated optics: theory and technology. Springer, Berlin Heidelberg New York, p 32Google Scholar
  65. 65.
    Duguay MA, Kokubun Y, Koch TL (1986) Appl Phys Lett 49:13CrossRefGoogle Scholar
  66. 66.
    Baba T, Kokubun Y (1992) IEEE J Quantum Elect 28:1689Google Scholar
  67. 67.
    Baba T, Kokubun Y (1989) IEEE Phot Tech Lett 1:232Google Scholar
  68. 68.
    Suhara T, Handa Y (1982) Appl Phys Lett 40:120CrossRefGoogle Scholar
  69. 69.
    Stuitus W, Streifer W (1977) Appl Opt 16:3218Google Scholar
  70. 70.
    Takato N, Yasu M (1986) Electron Lett 22:321Google Scholar
  71. 71.
    Kubica J (1992) J Lightwave Technol 16:767Google Scholar
  72. 72.
    Mao ZM, Huang WP (1993) J Lightwave Technol 11:1183CrossRefGoogle Scholar
  73. 73.
    Garcés I, Villuendas F, Vallés J, Domínguez C, Moreno M (1996) J Lightwave Technol 14:798Google Scholar
  74. 74.
    Kawabata Y, Tahara R, Kamichika T, Imasaka T, Ishibashi N (1990) Anal Chem 62:1528Google Scholar
  75. 75.
    Ertas N, Akkaya EU, Ataman OY (2000) Talanta 51:693CrossRefGoogle Scholar
  76. 76.
    McCreery R, Fleischman M, Hendra P (1983) Anal Chem 55:146Google Scholar
  77. 77.
    Dao NQ, Jouan M (1993) Sens Actuators B 11:147CrossRefGoogle Scholar
  78. 78.
    Andres RT, Sevilla F (1991) Anal Chim Acta 251:165CrossRefGoogle Scholar
  79. 79.
    Kirkbright GF, Narayanaswamy R, Welti NA (1984) Analyst 109:15Google Scholar
  80. 80.
    Hisamoto H, Kim K, Manabe Y, Sasaki K, Minamitani H, Suzuki K (1997) Anal Chim Acta 342:31CrossRefGoogle Scholar
  81. 81.
    Garcés N, Villuendas F, Salinas I, Puyol M, Alonso J, Domínguez C, Llobera A (1999) Sens Actuators B 60:191Google Scholar
  82. 82.
    Domínguez C, Rodríguez JA, Lechuga LM (2003) In: Alegret S (ed) Comprehensive analytical chemistry, vol XXXIX. Elsevier, Amsterdam, p 541Google Scholar
  83. 83.
    Ramsden JJ (1998) Biosens Bioelectron 13:593CrossRefGoogle Scholar
  84. 84.
    Dübendorfer J, Kunz RE, Jobst G, Moser I, Urban G (1998) Sens Actuators B 50:210Google Scholar
  85. 85.
    Brandenburg A, Gombert A (1993) Sens Actuators B 17:35CrossRefGoogle Scholar
  86. 86.
    Skládal P, Deng A, Kolář V (1999) Anal Chim Acta 399:29Google Scholar
  87. 87.
    Fisher MI, Tjärnhage T (2000) Biosens Bioelectron 15:463CrossRefGoogle Scholar
  88. 88.
    Lenney JP, Goddard NJ, Morey JC, Snook, RD, Fielden PR (1997) Sens Actuators B 38–39:212Google Scholar
  89. 89.
    Hulme J, Malins C, Singh K, Fielden PR, Goddard NJ (2002) Analyst 127:1233CrossRefGoogle Scholar
  90. 90.
    Fabricius N, Gauglitz G, Ingenhoff J (1992) Sens Actuators 7:672Google Scholar
  91. 91.
    Lechuga LM, Lenferink ATM, Kooyman RPH, Greve J (1995) Sens Actuators B 24–25:762Google Scholar
  92. 92.
    Schipper EF, Bergevoet AJH, Kooyman RPH, Greve J (1997) Anal Chim Acta 341:171CrossRefGoogle Scholar
  93. 93.
    Kempen LU, Kunz RE (1997) Sens Actuators B 38–39:295Google Scholar
  94. 94.
    Qi Z, Matsuda N, Itoh K, Murabayashi M, Lavers CR (2002) Sens Actuators B 81:254CrossRefGoogle Scholar
  95. 95.
    Brandenburg A (1997) Sens Actuators B 38–39:266Google Scholar
  96. 96.
    Brynda E, Houska M, Brandenburg A, Wikersta A (2002) Biosens Bioelectron 17:665CrossRefGoogle Scholar
  97. 97.
    Ymeti A, Kanger JS, Wijn R, Lambeck PV, Greve J (2002) Sens Actuators B 83:1CrossRefGoogle Scholar
  98. 98.
    Woodruff SD, Yeung ES (1982) Anal Chem 54:1174CrossRefGoogle Scholar
  99. 99.
    Correia JH, Bartek M, Wolffenbuttel RF (1999) Sens Actuators A 76:191Google Scholar
  100. 100.
    Bartek M, Correia JH, Wolffenbuttel RF (1999) J Micromech Microeng 9:162CrossRefGoogle Scholar
  101. 101.
    Harris RD, Wilkinson JS (1995) Sens Actuators B 29:261CrossRefGoogle Scholar
  102. 102.
    Ctyroky J, Homola J, Lambeck PV, Musa S, Hoekstra HJWM, Harris RD, Wilkinson JS, Usievich B, Lyndin NM (1999) Sens Actuators B 54:66Google Scholar
  103. 103.
    Fujiwara K, Simeonsson JB, Smith BW, Wineforder JD (1988) Anal Chem 60:1065Google Scholar
  104. 104.
    Kieslinger D, Draxler S, Trznadel K, Lippitsch ME (1997) Sens Actuators B 38–39:300Google Scholar
  105. 105.
    Duveneck GL, Pawlak M, Neuschäfer D, Bär E, Budach W, Pieles U, Ehrat M (1997) Sens Actuators B 38–39:88Google Scholar
  106. 106.
    Srivastava R, Bao C, Gómez-Reino C (1996) Sens Actuators A 51:165Google Scholar
  107. 107.
    Plowman TE, Durstchi JD, Wang HK, Christensen DA, Herron JN, Reichert WM (1999) Anal Chem 71:4344CrossRefGoogle Scholar
  108. 108.
    Mac Craith BD, Ruddy V, Potter C, O’Kelly B, McGilp JF (1991) Electron Lett 27:1247Google Scholar
  109. 109.
    Wiki M, Gao H, Juvet M, Kunz RE (2001) Biosens Bioelectron 16:37CrossRefGoogle Scholar
  110. 110.
    Wiki M, Kunz RE, Voirin G, Tiefenthaler K, Bernard A (1998) Biosens Bioelectron 13:1181CrossRefGoogle Scholar
  111. 111.
    Challener WA, Edwards JD, McGowan RW, Skorjanec J, Yang Z (2000) Sens Actuators B 71:42CrossRefGoogle Scholar
  112. 112.
    Rowe CA, Tender LM, Feldstein MJ, Golden JP, Scruggs SB, MacCraith BD, Cras JJ, Liegler FS (1999) Anal Chem 71:3846Google Scholar
  113. 113.
    Tóth K, Nagy G, Lan BTT, Jeney J, Choquette SJ (1997) Anal Chim Acta 353:1Google Scholar
  114. 114.
    Saavedra S, Yang L (1995) Anal Chem 67:1307Google Scholar
  115. 115.
    Saggese S, Harrington JA, Sigel G (1991) Opt Lett 16:27Google Scholar
  116. 116.
    Davies J, Mendoça J (2000) Phys Rev E 62:7168CrossRefGoogle Scholar
  117. 117.
    Saito Y, Kanaya T, Nomura A, Kano T (1993) Opt Lett 18:2150Google Scholar
  118. 118.
    Wei W, Qushe H, Tao W, Minzhao F, Yuanmin L, Gouxia R (1992) Anal Chem 64:22Google Scholar
  119. 119.
    Shahriari MR, Zhou Q, Sigel GH (1988) Opt Lett 13:407Google Scholar
  120. 120.
    Zhou Q, Sigel GH (1989) Proc SPIE Int Soc Opt Eng 1172:157Google Scholar
  121. 121.
    Shahriari MR, Ding JY (1994) In: Klein LC (ed) Sol-gel optics: processing and applications, chap 13. Kluwer, BostonGoogle Scholar
  122. 122.
    Wolf S, Tauber RN (1986) Silicon processing, vol 1. Lattice, Sunset Beach, CAGoogle Scholar
  123. 123.
    Zaatar Y, Zaouk D, Bechara J, Khoury A, Llinaress C, Charles JP (2000) Mater Sci Eng B 74:296CrossRefGoogle Scholar
  124. 124.
    DeGrandpre MD, Burgess LW, White PL, Goldman DS (1990) Anal Chem 62:2012CrossRefGoogle Scholar
  125. 125.
    Lee JE, Saavedra SS (1994) Anal Chim Acta 285:265CrossRefGoogle Scholar
  126. 126.
    Bürk J, Zimmermann B, Mayer J, Ache HJ (1996) Fresenius J Anal Chem 354:284Google Scholar
  127. 127.
    Ge Z, Brown CW, Sun L, Yang SC (1993) Anal Chem 65:2335Google Scholar
  128. 128.
    Garcés I, Villuendas F, Subías J, Alonso J, del Valle M, Domínguez C (1997) Opt Lett 23:225Google Scholar
  129. 129.
    Kim K, Minamitani H, Hisamoto H, Suzuki K, Kang S (1997) Anal Chim Acta 343:199CrossRefGoogle Scholar
  130. 130.
    Moreno M, Domínguez C, Muñoz F, Calderer J, Morante JR (1997) Sens Actuators A 62:524Google Scholar
  131. 131.
    Moreno M, Garcés I, Muñoz J, Domínguez C, Calderer J, Villuendas F, Pelayo J (1995) Advances in science and technology: advanced materials in optics, electrooptics and communication technologies, vol 11. Vinzencini, Faenza, p 465Google Scholar
  132. 132.
    Moreno M, Muñoz J, Garrido B, Samitier J, Calderer J, Domínguez C (1995) Advances in science and technology: advances in inorganic films and coatings, vol 5. Vinzencini, Faenza, p 149Google Scholar
  133. 133.
    Domínguez C, Muñoz J, González R, Tudanca M (1993) Sens Actuators A 37–38:779Google Scholar
  134. 134.
    Puyol M, del Valle M, Garcés N, Villuendas F, Domínguez C, Alonso J (1999) Anal Chem 71:5037CrossRefGoogle Scholar
  135. 135.
    Kovacs GTA, Petersen K, Albin M (1996) Anal Chem News Features 407AGoogle Scholar
  136. 136.
    Kang L, Dessy RE (1990) Anal Chem 21:377Google Scholar
  137. 137.
    Bakker E, Bühlmann P, Pretsch E (1997) Chem Rev 97:3083CrossRefGoogle Scholar
  138. 138.
    Morf WE, Seiler K, Lehmann B, Behringer C, Tau S, Hartman K, Sorensen PR, Simon W (1989) Ion selective electrodes, vol 5. Pergamon, New York, p 115Google Scholar
  139. 139.
    Seiler K, Simon W (1992) Sens Actuators B 6:295CrossRefGoogle Scholar
  140. 140.
    Spichiger U, Simon W, Bakker E, Lerchi M, Bühlmann P, Haug JP, Kuratli M, Ozawa S, West S (1993) Sens Actuators B 11:1Google Scholar
  141. 141.
    Bühlmann P, Pretsch E, Bakker E (1998) Chem Rev 98:1593Google Scholar
  142. 142.
    Spichiger UE, Seiler K, Wang K, Suter F, Morf WE, Simon W (1991) Proc SPIE 1510:118Google Scholar
  143. 143.
    Wang K, Seiler K, Morf WE, Spichiger UE, Simon W, Linder E, Pungor E (1990) Anal Sci 6:715Google Scholar
  144. 144.
    Miltsov S, Encinas C, Alonso J (2001) Tetrahedron Lett 42:6129CrossRefGoogle Scholar
  145. 145.
    Hisamoto H, Satoh S, Satoh K, Tsubuku M, Siswanta D, Shichi Y, Koike Y, Suzuki K (1999) Anal Chim Acta 396:131CrossRefGoogle Scholar
  146. 146.
    Sotomayor PT, Raimundo IM Jr, Neto GO, de Oliveira WA (1998) Sens Actuators B 51:382CrossRefGoogle Scholar

Copyright information

© Springer-Verlag Berlin Heidelberg 2005

Authors and Affiliations

  • Mar Puyol
    • 1
  • Francisco Villuendas
    • 1
  • Carlos Domínguez
    • 2
  • Víctor Cadarso
    • 2
  • Andreu Llobera
    • 3
  • Iñigo Salinas
    • 4
  • Ignacio Garcés
    • 4
  • Julián Alonso
    • 5
  1. 1.Dpto. Física AplicadaUniversidad de ZaragozaSaragossaSpain
  2. 2.Centro Nacional de Microelectrónica, BellaterraBarcelonaSpain
  3. 3.Institut für MikrotechnikTechnische Universität BraunschweigBraunschweigGermany
  4. 4.Dpto. Ingeniería Electrónica y ComunicacionesUniversidad de Zaragoza, CPSSaragossaSpain
  5. 5.Grup de Sensors i Biosensors, Unitat de Química AnalíticaEdifici Ciències, BellaterraBarcelonaSpain

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