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Immunobiology of Natural Killer Cell Receptors pp 77–89Cite as

Extending Missing-Self? Functional Interactions Between Lectin-like Nkrp1 Receptors on NK Cells with Lectin-like Ligands

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Part of the book series: Current Topics in Microbiology and Immunology ((CT MICROBIOLOGY,volume 298))

Abstract

The functions of natural killer (NK) cells are clearly regulated by major histocompatibility complex (MHC) class Imolecules on their cellular targets. In mice, this is due to the action of MHC-specific inhibitory receptors belonging to the Ly49 family of lectin-likemolecules. The Ly49 receptors are encoded in theNKgene complex (NKC) that contains clusters of genes for other lectin-like receptors on NK cells and other hematopoietic cells. Interestingly, recent studies have shown that some of these lectin-like receptors, belonging to the Nkrp1 family, can recognize other lectin-like molecules, termed Clr, also encoded in the NKC. These genetically linked loci for receptor-ligand pairs suggest a genetic strategy to preserve this interaction and show several other contrasts with Ly49-MHC interactions. In this review, we discuss these issues and summarize recent developments concerning this non-MHC-dependent regulation of NK cell function.

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Authors and Affiliations

  1. Rheumatology Division, Department of Medicine, Howard Hughes Medical Institute, Washington University School of Medicine, St. Louis, MO, 63110, USA

    B. F. M. Plougastel & W. M. Yokoyama

Authors
  1. B. F. M. Plougastel
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  2. W. M. Yokoyama
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Corresponding author

Correspondence to W. M. Yokoyama .

Editor information

Editors and Affiliations

  1. Atlanta, Georgia

    R.W. Compans

  2. Birmingham, Alabama

    M.D. Cooper

  3. Kyoto

    T. Honjo

  4. Philadelphia, Pennsylvania

    H. Koprowski

  5. Basel

    F. Melchers

  6. La Jolla, California

    M.B.A. Oldstone

  7. Oslo

    S. Olsnes

  8. Bethesda, Maryland

    M. Potter

  9. La Jolla, California

    P.K. Vogt

  10. Munich

    H. Wagner

  11. Laboratory of NK Cells and Innate Immunity, Centre d’Immunologie de Marseille-Luminy (CIML), CNRS-INSERM-Université de la Méditerranée, Campus de Luminy, Case 906, 13288, Marseille Cedex 09, France

    Eric Vivier DVM, PhD.

  12. Department of Pathology and Immunology, Washington University School of Medicine, West Building, Rooms 4724, Box 8118 660 South Euclid Ave, St. Louis, MO, 63110, USA

    Marco Colonna M.D.

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© 2006 Springer-Verlag Berlin Heidelberg

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Plougastel, B.F.M., Yokoyama, W.M. (2006). Extending Missing-Self? Functional Interactions Between Lectin-like Nkrp1 Receptors on NK Cells with Lectin-like Ligands. In: Compans, R., et al. Immunobiology of Natural Killer Cell Receptors. Current Topics in Microbiology and Immunology, vol 298. Springer, Berlin, Heidelberg. https://doi.org/10.1007/3-540-27743-9_4

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