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Immunobiology of Natural Killer Cell Receptors pp 259–277Cite as

NK Cells in Autoimmune Disease

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Part of the book series: Current Topics in Microbiology and Immunology ((CT MICROBIOLOGY,volume 298))

Abstract

The role of NK cells in autoimmunity has not been extensively studied. Speaking for a disease-promoting role for NK cells in autoimmune diseases are recent results suggesting that IFN-γ production by NK cells may help adaptive immune responses diverge in the direction of a Th1 response. NK cells may also be involved in direct killing of tissue cells, which could lead to acceleration of autoimmunity. However, NK cells have also been shown to protect from some autoimmune diseases. A possible reason for this discrepancy may lie in the capacity of NK cells also to produce Th2 cytokines, which could downregulate the Th1 responses that are common in autoimmune disorders. Thus there is at present no coherent view on the role of NK cells in autoimmunity, and more work is needed to clarify why NK cells in some cases aggravate disease and in some cases protect from disease.

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Authors and Affiliations

  1. Karolinska Institute, Microbiology and Tumor Biology Center, Box 280, 17177, Stockholm, Sweden

    S. Johansson, H. Hall, L. Berg & P. Höglund

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  1. S. Johansson
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  2. H. Hall
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  3. L. Berg
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  4. P. Höglund
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Correspondence to P. Höglund .

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Editors and Affiliations

  1. Atlanta, Georgia

    R.W. Compans

  2. Birmingham, Alabama

    M.D. Cooper

  3. Kyoto

    T. Honjo

  4. Philadelphia, Pennsylvania

    H. Koprowski

  5. Basel

    F. Melchers

  6. La Jolla, California

    M.B.A. Oldstone

  7. Oslo

    S. Olsnes

  8. Bethesda, Maryland

    M. Potter

  9. La Jolla, California

    P.K. Vogt

  10. Munich

    H. Wagner

  11. Laboratory of NK Cells and Innate Immunity, Centre d’Immunologie de Marseille-Luminy (CIML), CNRS-INSERM-Université de la Méditerranée, Campus de Luminy, Case 906, 13288, Marseille Cedex 09, France

    Eric Vivier DVM, PhD.

  12. Department of Pathology and Immunology, Washington University School of Medicine, West Building, Rooms 4724, Box 8118 660 South Euclid Ave, St. Louis, MO, 63110, USA

    Marco Colonna M.D.

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Johansson, S., Hall, H., Berg, L., Höglund, P. (2006). NK Cells in Autoimmune Disease. In: Compans, R., et al. Immunobiology of Natural Killer Cell Receptors. Current Topics in Microbiology and Immunology, vol 298. Springer, Berlin, Heidelberg. https://doi.org/10.1007/3-540-27743-9_13

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