Skip to main content
SpringerLink
Log in
Book cover

Immunobiology of Natural Killer Cell Receptors pp 1–21Cite as

Strategies of Natural Killer Cell Recognition and Signaling

  • Chapter

Part of the book series: Current Topics in Microbiology and Immunology ((CT MICROBIOLOGY,volume 298))

Abstract

The participation of natural killer (NK) cells in multiple aspects of innate and adaptive immune responses is supported by the wide array of stimulatory and inhibitory receptors they bear. Here we review the receptor-ligand interactions and subsequent signaling events that culminate in NK effector responses. Whereas some receptor-ligand interactions result in activation of both NK cytotoxicity and cytokine production, others have more subtle effects, selectively activating only one pathway or having distinct context-dependent effects. Recent approaches offer ways to unravel how the integration of complex signaling networks directs the NK response.

This is a preview of subscription content, log in via an institution.

Chapter
USD   29.95
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
eBook
USD   129.00
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
Softcover Book
USD   169.99
Price excludes VAT (USA)
  • Compact, lightweight edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info
Hardcover Book
USD   169.99
Price excludes VAT (USA)
  • Durable hardcover edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Purchases are for personal use only

Learn about institutional subscriptions

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

References

  • Abi-Rached L, and Parham P (2005). Natural selection drives recurrent formation of activating KIR and Ly49 from inhibitory homologues. J Exp Med 201:1319–1332

    Article  PubMed  CAS  Google Scholar 

  • Arase H, and Lanier LL (2002). Virus-driven evolution of natural killer cell receptors. Microbes Infect 4: 1505–12

    Article  PubMed  CAS  Google Scholar 

  • Arnon TI, Achdout H, Levi O, Markel G, Saleh N, Katz G, Gazit R, Gonen-Gross T, Hanna J, Nahari E, Porgador A, Honigman A, Plachter B, Mevorach D, Wolf DG, and Mandelboim O (2005). Inhibition of the NKp30 activating receptor by pp65 of human cytomegalovirus. Nat Immunol 6:515–23

    Article  PubMed  CAS  Google Scholar 

  • Azzoni L, Kamoun M, Salcedo TW, Kanakaraj P, and Perussia B (1992). Stimulation of Fcɣ RIIIA results in phospholipase C-γ1 tyrosine phosphorylation and p56lck activation. J Exp Med 176:1745–50

    Article  PubMed  CAS  Google Scholar 

  • Barber DF, Faure M, and Long EO (2004). LFA-1 contributes an early signal for NK cell cytotoxicity. J Immunol 173:3653–9

    PubMed  CAS  Google Scholar 

  • Barber DF, and Long EO (2003). Coexpression of CD58 or CD48 with intercellular adhesion molecule 1 on target cells enhances adhesion of resting NK cells. J Immunol 170:294–9

    PubMed  CAS  Google Scholar 

  • Billadeau DD, Brumbaugh KM, Dick CJ, Schoon RA, Bustelo XR, and Leibson PJ (1998). The Vav-Rac1 pathway in cytotoxic lymphocytes regulates the generation of cellmediated killing. J Exp Med 188:549–59

    Article  PubMed  CAS  Google Scholar 

  • Billadeau DD, Upshaw JL, Schoon RA, Dick CJ, and Leibson PJ (2003). NKG2D-DAP10 triggers human NK cell-mediated killing via a Syk-independent regulatory pathway. Nat Immunol 4:557–64

    Article  PubMed  CAS  Google Scholar 

  • Bloushtain N, Qimron U, Bar-Ilan A, Hershkovitz O, Gazit R, Fima E, Korc M, Vlodavsky I, Bovin NV, and Porgador A (2004). Membrane-associated heparan sulfate proteoglycans are involved in the recognition of cellular targets by NKp30 and NKp46. J Immunol 173:2392–401

    PubMed  CAS  Google Scholar 

  • Boles KS, Barchet W, Diacovo T, Cella M, and Colonna M (2005). The tumor suppressor TSLC1/NECL-2 triggers NK cell and CD8+ T cell responses through the cell surface receptor CRTAM. Blood 106:779–786

    Article  PubMed  CAS  Google Scholar 

  • Bonnema JD, Rivlin KA, Ting AT, Schoon RA, Abraham RT, and Leibson PJ (1994). Cytokine-enhanced NK cell-mediated cytotoxicity. Positive modulatory effects of IL-2 and IL-12 on stimulus-dependent granule exocytosis. J Immunol 152:2098–104

    PubMed  CAS  Google Scholar 

  • Borrego F, Ulbrecht M, Weiss EH, Coligan JE, and Brooks AG (1998). Recognition of human histocompatibility leukocyte antigen (HLA)-E complexed with HLA class I signal sequence-derived peptides by CD94/NKG2 confers protection from natural killer cell-mediated lysis. J Exp Med 187:813–8

    Article  PubMed  CAS  Google Scholar 

  • Bottino C, Augugliaro R, Castriconi R, Nanni M, Biassoni R, Moretta L, and Moretta A (2000). Analysis of the molecular mechanism involved in 2B4-mediated NK cell activation: evidence that human 2B4 is physically and functionally associated with the linker for activation of T cells. Eur J Immunol 30:3718–22

    Article  PubMed  CAS  Google Scholar 

  • Bottino C, Castriconi R, Pende D, Rivera P, Nanni M, Carnemolla B, Cantoni C, Grassi J, Marcenaro S, Reymond N, Vitale M, Moretta L, Lopez M, and Moretta A (2003). Identification of PVR (CD155) and Nectin-2 (CD112) as cell surface ligands for the human DNAM-1 (CD226) activating molecule. J Exp Med 198:557–67

    Article  PubMed  CAS  Google Scholar 

  • Braud V, Jones EY, and McMichael M (1997). The human major histocompatibility complex class Ib molecule HLA-E binds signal sequence-derived peptides with primary anchor residues at positions 2 and 9. Eur J Immunol 27:1164–9

    PubMed  CAS  Google Scholar 

  • Braud VM, Allan DS, O’Callaghan CA, Soderstrom K, D’Andrea A, Ogg GS, Lazetic S, Young NT, Bell JI, Phillips JH, Lanier LL, and McMichael AJ (1998). HLA-E binds to natural killer cell receptors CD94/NKG2A, B and C. Nature 391:795–9

    Article  PubMed  CAS  Google Scholar 

  • Cella M, Fujikawa K, Tassi I, Kim S, Latinis K, Nishi S, Yokoyama W, Colonna M, and Swat W (2004). Differential requirements for Vav proteins in DAP10-and ITAM-mediated NK cell cytotoxicity. J Exp Med 200: 817–23

    Article  PubMed  CAS  Google Scholar 

  • Cerwenka A, Bakker ABH, McClanahan T, Wagner J, Wu J, Phillips JH, and Lanier LL (2000). Retinoic acid early inducible genes define a ligand family for the activating NKG2D receptor in Mice. Immunity 12:721–7

    Article  PubMed  CAS  Google Scholar 

  • Cerwenka A, Baron JL, and Lanier LL (2001). Ectopic expression of retinoic acid early inducible-1 gene (RAE-1) permits natural killer cell-mediated rejection of a MHC class I-bearing tumor in vivo. Proc Natl Acad Sci USA 98: 11521–6.

    Article  PubMed  CAS  Google Scholar 

  • Cerwenka A, and Lanier L (2001). Natural killer cells, viruses and cancer. Nat Rev Immunol 1:41–9

    Article  PubMed  CAS  Google Scholar 

  • Chalifour A, Jeannin P, Gauchat JF, Blaecke A, Malissard M, N’Guyen T, Thieblemont N, and Delneste Y (2004). Direct bacterial protein PAMP recognition by human NK cells involves TLRs and triggers α-defensin production. Blood 104:1778–83

    Article  PubMed  CAS  Google Scholar 

  • Chan G, Hanke T, and Fischer KD (2001). Vav-1 regulates NK T cell development and NK cell cytotoxicity. Eur J Immunol 31:2403–10

    Article  PubMed  CAS  Google Scholar 

  • Chang C, Dietrich J, Harpur AG, Lindquist JA, Haude A, Loke YW, King A, Colonna M, Trowsdale J, and Wilson MJ (1999). Cutting edge: KAP10, a novel transmembrane adapter protein genetically linked to DAP12 but with unique signaling properties. J Immunol 163:4651–4

    PubMed  CAS  Google Scholar 

  • Chapman TL, Heikeman AP, and Bjorkman PJ (1999). The inhibitory receptor LIR-1 uses a common binding interaction to recognize class I MHC molecules and the viral homolog UL18. Immunity 11:603–13

    Article  PubMed  CAS  Google Scholar 

  • Chini CC, Boos MD, Dick CJ, Schoon RA, and Leibson PJ (2000). Regulation of p38 mitogen-activated protein kinase during NK cell activation. Eur J Immunol 30:2791–8

    Article  PubMed  CAS  Google Scholar 

  • Chuang SS, Kumaresan PR, and Mathew PA (2001). 2B4 (CD244)-mediated activation of cytotoxicity and IFN-γ release in human NK cells involves distinct pathways. J Immunol 167:6210–6

    PubMed  CAS  Google Scholar 

  • Colonna M, Navarro F, Bellon T, Liano M, Garcia P, Samaridis J, Angman L, Cella M, and Lopez-Botet M (1997). A common inhibitory receptor for major histocompatibility complex class I molecules on human lymphoid and myelomonocytic cells. J Exp Med 186:1809–18

    Article  PubMed  CAS  Google Scholar 

  • Colucci F, Di Santo JP, and Leibson PJ (2002). Natural killer cell activation in mice and men: different triggers for similar weapons? Nat Immunol 3:807–13

    Article  PubMed  CAS  Google Scholar 

  • Colucci F, Rosmaraki E, Bregenholt S, Samson SI, Di Bartolo V, Turner M, Vanes L, Tybulewicz V, and Di Santo JP (2001). Functional dichotomy in natural killer cell signaling: Vav1-dependent and-independent mechanisms. J Exp Med 193:1413–24

    Article  PubMed  CAS  Google Scholar 

  • Cooper MA, Fehniger TA, Fuchs A, Colonna M, and Caligiuri MA (2004). NK cell and DC interactions. Trends Immunol 25:47–52

    Article  PubMed  CAS  Google Scholar 

  • Davis DM (2002). Assembly of the immunological synapse for T cells and NK cells. Trends Immunol 23:356–63

    Article  PubMed  CAS  Google Scholar 

  • Deane JA, and Fruman DA (2004). Phosphoinositide 3-kinase: diverse roles in immune cell activation. Annu Rev Immunol 22:563–98

    Article  PubMed  CAS  Google Scholar 

  • Diefenbach A, Jamieson AM, Liu SD, Shastri N, and Raulet DH (2000). Ligands for the murine NKG2D receptor: expression by tumor cells and activation of NK cells and macrophages. Nat Immunol 1:119–26.

    Article  PubMed  CAS  Google Scholar 

  • Diefenbach A, Jensen ER, Jamieson AM, and Raulet DH (2001). Rae1 and H60 ligands of the NKG2D receptor stimulate tumour immunity. Nature 413:165–71.

    Article  PubMed  CAS  Google Scholar 

  • Diefenbach A, Tomasello E, Lucas M, Jamieson AM, Hsia JK, Vivier E, and Raulet DH (2002). Selective associations with signaling proteins determine stimulatory versus costimulatory activity of NKG2D. Nat Immunol 3:1142–9.

    Article  PubMed  CAS  Google Scholar 

  • Engel P, Eck MJ, and Terhorst C (2003). The SAP and SLAM families in immune responses and X-linked lymphoproliferative disease. Nat Rev Immunol 3:813–21

    Article  PubMed  CAS  Google Scholar 

  • Ferlazzo G, and Munz C (2004). NK cell compartments and their activation by dendritic cells. J Immunol 172: 1333–9

    PubMed  CAS  Google Scholar 

  • Franksson L, Sundback J, Achour A, Bernlind J, Glas R, and Karre K (1999). Peptide dependency and selectivity of the NK cell inhibitory receptor Ly-49C. Eur J Immunol 29:2748–58

    Article  PubMed  CAS  Google Scholar 

  • Fuchs A, Cella M, Giurisato E, Shaw AS, and Colonna M (2004). Cutting edge: CD96 (tactile) promotes NK cell-target cell adhesion by interacting with the poliovirus receptor (CD155). J Immunol 172:3994–8

    PubMed  CAS  Google Scholar 

  • Galandrini R, Micucci F, Tassi I, Cifone MG, Cinque B, Piccoli M, Frati L, and Santoni A (2005). ARF6: A new player in the FcγRIIIA lymphocyte-mediated cytotoxicity. Blood 106:577–583

    Article  PubMed  CAS  Google Scholar 

  • Galandrini R, Palmieri G, Piccoli M, Frati L, and Santoni A (1999). Role for the Rac1 exchange factor Vav in the signaling pathways leading to NK cell cytotoxicity. J Immunol 162:3148–52

    PubMed  CAS  Google Scholar 

  • Garcia-Lora A, Algarra I, Collado A, and Garrido F (2003). Tumour immunology, vaccination and escape strategies. Eur J Immunogenet 30:177–83.

    Article  PubMed  CAS  Google Scholar 

  • Gilfillan S, Ho EL, Cella M, Yokoyama WM, and Colonna M (2002). NKG2D recruits two distinct adapters to trigger NK cell activation and costimulation. Nat Immunol 3:1150–5.

    Article  PubMed  CAS  Google Scholar 

  • Gismondi A, Cifaldi L, Mazza C, Giliani S, Parolini S, Morrone S, Jacobelli J, Bandiera E, Notarangelo L, and Santoni A (2004). Impaired natural and CD16-mediated NK cell cytotoxicity in patients withWAS and XLT: ability of IL-2 to correct NK cell functional defect. Blood 104:436–43

    Article  PubMed  CAS  Google Scholar 

  • Gismondi A, Jacobelli J, Mainiero F, Paolini R, Piccoli M, Frati L, and Santoni A (2000). Cutting edge: functional role for proline-rich tyrosine kinase 2 in NK cell-mediated natural cytotoxicity. J Immunol 164: 2272–6

    PubMed  CAS  Google Scholar 

  • Groh V, Bahram S, Bauer S, Herman A, Beauchamp M, and Spies T (1996). Cell stress-regulated human major histocompatibility complex class I gene expressed in gastrointestinal epithelium. Proc Natl Acad Sci USA 93: 12445–50.

    Article  PubMed  CAS  Google Scholar 

  • Hanke T, Takizawa H, McMahon CW, Busch DH, Pamer EG, Miller JD, Altman JD, Liu Y, Cado D, Lemonnier FA, Bjorkman PJ, and Raulet DH (1999). Direct assessment of MHC class I binding by seven Ly49 inhibitory NK cell receptors. Immunity 11:67–77

    Article  PubMed  CAS  Google Scholar 

  • Hansasuta P, Dong T, Thananchai H, Weekes M, Willberg C, Aldemir H, Rowland-Jones S, and Braud VM (2004). Recognition of HLA-A3 and HLA-A11 by KIR3DL2 is peptide-specific. Eur J Immunol 34:1673–9

    Article  PubMed  CAS  Google Scholar 

  • Helander TS, and Timonen T (1998). Adhesion in NK cell function. Curr Top Microbiol Immunol 230:89–99

    PubMed  CAS  Google Scholar 

  • Hiby SE, Walker JJ, O’shaughnessy K M, Redman CW, Carrington M, Trowsdale J, and Moffett A (2004). Combinations ofmaternal KIR and fetal HLA-C genes influence the risk of preeclampsia and reproductive success. J Exp Med 200:957–65

    Article  PubMed  CAS  Google Scholar 

  • Hornung V, Rothenfusser S, Britsch S, Krug A, Jahrsdorfer B, Giese T, Endres S, and Hartmann G (2002). Quantitative expression of toll-like receptor 1-10 mRNA in cellular subsets of human peripheral blood mononuclear cells and sensitivity to CpG oligodeoxynucleotides. J Immunol 168:4531–7

    PubMed  CAS  Google Scholar 

  • Jevremovic D, Billadeau DD, Schoon RA, Dick CJ, Irvin BJ, Zhang W, Samelson LE, Abraham RT, and Leibson PJ (1999). Cutting edge: a role for the adaptor protein LAT in human NK cell-mediated cytotoxicity. J Immunol 162: 2453–6

    PubMed  CAS  Google Scholar 

  • Jevremovic D, Billadeau DD, Schoon RA, Dick CJ, and Leibson PJ (2001). Regulation of NK cell-mediated cytotoxicity by the adaptor protein 3BP2. J Immunol 166:7219–28

    PubMed  CAS  Google Scholar 

  • Jiang K, Zhong B, Gilvary DL, Corliss BC, Hong-Geller E, Wei S, and Djeu JY (2000). Pivotal role of phosphoinositide-3 kinase in regulation of cytotoxicity in natural killer cells. Nat Immunol 1:419–25

    Article  PubMed  CAS  Google Scholar 

  • Karre K, Ljunggren HG, Piontek G, and Kiessling R (1986). Selective rejection of H-2-deficient lymphoma variants suggests alternative immune defence strategy. Nature 319:675–8

    Article  PubMed  CAS  Google Scholar 

  • Katz G, Gazit R, Arnon TI, Gonen-Gross T, Tarcic G, Markel G, Gruda R, Achdout H, Drize O, Merims S, and Mandelboim O (2004). MHC class I-independent recognition of NK-activating receptor KIR2DS4. J Immunol 173: 1819–25

    PubMed  CAS  Google Scholar 

  • Khurana D, and Leibson PJ (2003). Regulation of lymphocyte-mediated killing by GTP-binding proteins. J Leukoc Biol 73:333–8

    Article  PubMed  CAS  Google Scholar 

  • Klem J, Verrett PC, Kumar V, and Schatzle JD (2002). 2B4 is constitutively associated with linker for the activation of T cells in glycolipid-enriched microdomains: properties required for 2B4 lytic function. J Immunol 169:55–62

    PubMed  CAS  Google Scholar 

  • Koyasu S (2003). The role of PI3K in immune cells. Nat Immunol 4:313–9

    Article  PubMed  CAS  Google Scholar 

  • Kraft JR, Vance RE, Pohl J, Martin AM, Raulet DH, and Jensen PE (2000). Analysis of Qa-1(b) peptide binding specificity and the capacity of CD94/NKG2A to discriminate between Qa-1-peptide complexes. J Exp Med 192: 613–24

    Article  PubMed  CAS  Google Scholar 

  • Kumar V, and McNerney ME (2005). A new self: MHC-class-I-independent Natural-killer-cell self-tolerance. Nat Rev Immunol 5:363–74

    Article  PubMed  CAS  Google Scholar 

  • Kuramochi M, Fukuhara H, Nobukuni T, Kanbe T, Maruyama T, Ghosh HP, Pletcher M, Isomura M, Onizuka M, Kitamura T, Sekiya T, Reeves RH, and Murakami Y (2001). TSLC1 is a tumor-suppressor gene in human non-small-cell lung cancer. Nat Genet 27:427–30

    Article  PubMed  CAS  Google Scholar 

  • Lanier LL (2003). Natural killer cell receptor signaling. Curr Opin Immunol 15:308–14

    Article  PubMed  CAS  Google Scholar 

  • Lee KM, Bhawan S, Majima T, Wei H, Nishimura MI, Yagita H, and Kumar V (2003). Cutting edge: the NK cell receptor 2B4 augments antigen-specific T cell cytotoxicity through CD48 ligation on neighboring T cells. J Immunol 170:4881–5

    PubMed  CAS  Google Scholar 

  • Lee KM, McNerney ME, Stepp SE, Mathew PA, Schatzle JD, Bennett M, and Kumar V (2004). 2B4 acts as a non-major histocompatibility complex binding inhibitory receptor on mouse natural killer cells. J Exp Med 199:1245–54

    Article  PubMed  CAS  Google Scholar 

  • Lee N, Llano M, Carretero M, Ishitani A, Navarro F, Lopez-Botet M, and Geraghty DE (1998). HLA-E is a major ligand for the natural killer inhibitory receptor CD94/NKG2A. Proc Natl Acad Sci USA 95:5199–204

    Article  PubMed  CAS  Google Scholar 

  • Liao F, Shin HS, and Rhee SG (1993). Cross-linking of Fc. RIIIA on natural killer cells results in tyrosine phosphorylation of PLC-.1 and PLC-.2. J Immunol 150:2668–74

    PubMed  CAS  Google Scholar 

  • Long EO (1999). Regulation of immune responses through inhibitory receptors. Annu Rev Immunol 17:875–904

    Article  PubMed  CAS  Google Scholar 

  • Maenaka K, Juji T, Nakayama T, Wyer JR, Gao GF, Maenaka T, Zaccai NR, Kikuchi A, Yabe T, Tokunaga K, Tadokoro K, Stuart DI, Jones EY, and Van Der Merwe PA (1999). Killer cell immunoglobulin receptors and T cell receptors bind peptide major histocompatibility complex class i with distinct thermodynamic and kinetic properties. J Biol Chem 274:28329–34

    Article  PubMed  CAS  Google Scholar 

  • Maghazachi AA (2003). G protein-coupled receptors in natural killer cells. J Leukoc Biol 74:16–24

    Article  PubMed  CAS  Google Scholar 

  • Mainiero F, Soriani A, Strippoli R, Jacobelli J, Gismondi A, Piccoli M, Frati L, and Santoni A (2000). RAC1/P38 MAPK signaling pathway controls β1 integrin-induced interleukin-8 production in human natural killer cells. Immunity 12:7–6

    Article  PubMed  CAS  Google Scholar 

  • Mandelboim O, Lieberman N, Lev M, Paul L, Arnon TI, Bushkin Y, Davis DM, Strominger JL, Yewdell JW, and Porgador A (2001). Recognition of haemagglutinins on virus-infected cells by NK p46 activates lysis by human NK cells. Nature 409:1055–60.

    Article  PubMed  CAS  Google Scholar 

  • Martin-Fontecha A, Thomsen LL, Brett S, Gerard C, Lipp M, Lanzavecchia A, and Sallusto F (2004). Induced recruitment of NK cells to lymph nodes provides IFN-γ for TH1 priming. Nat Immunol 5:1260–5

    Article  PubMed  CAS  Google Scholar 

  • McVicar DW, and Burshtyn DN (2001). Intracellular signaling by the killer immunoglobulin-like receptors and Ly49. Sci. STKE 2001:RE1

    Google Scholar 

  • McVicar DW, Taylor LS, Gosselin P, Willette-Brown J, Mikhael AI, Geahlen RL, Nakamura C, Linnemeyer P, Seaman WE, Anderson SK, Ortaldo JR, and Mason LH (1998). DAP12-mediated signal transduction in natural killer cells. A dominant role for the Syk protein-tyrosine kinase. J Biol Chem 273:32934–42

    Article  PubMed  CAS  Google Scholar 

  • Moretta A, Bottino C, Vitale M, Pende D, Cantoni C, Mingari MC, Biassoni R, and Moretta L (2001). Activating receptors and coreceptors involved in human natural killer cell-mediated cytolysis. Ann Rev Immunol 19: 197–223.

    Article  CAS  Google Scholar 

  • Moretta L, Bottino C, Pende D, Mingari MC, Biassoni R, and Moretta A (2002). Human natural killer cells: their origin, receptors and function. Eur J Immunol 32:1205–11.

    Article  PubMed  CAS  Google Scholar 

  • Morra M, Howie D, Grande MS, Sayos J, Wang N, Wu C, Engel P, and Terhorst C (2001a). X-linked lymphoproliferative disease: a progressive immunodeficiency. Annu Rev Immunol 19:657–82

    Article  PubMed  CAS  Google Scholar 

  • Morra M, Lu J, Poy F, Martin M, Sayos J, Calpe S, Gullo C, Howie D, Rietdijk S, Thompson A, Coyle AJ, Denny C, Yaffe MB, Engel P, Eck MJ, and Terhorst C (2001b). Structural basis for the interaction of the free SH2 domain EAT-2 with SLAM receptors in hematopoietic cells. EMBO J 20:5840–52

    Article  PubMed  CAS  Google Scholar 

  • Nguyen KB, Salazar-Mather TP, Dalod MY, Van Deusen JB, Wei XQ, Liew FY, Caligiuri MA, Durbin JE, and Biron CA (2002). Coordinated and distinct roles for IFN-αβ, IL-12, and IL-15 regulation of NK cell responses to viral infection. J Immunol 169:4279–87

    PubMed  CAS  Google Scholar 

  • Nichols KE, Ma CS, Cannons JL, Schwartzberg PL, and Tangye SG (2005). Molecular and cellular pathogenesis of X-linked lymphoproliferative disease. Immunol Rev 203:180–99

    Article  PubMed  CAS  Google Scholar 

  • Nutt SL, Brady J, Hayakawa Y, and Smyth MJ (2004). Interleukin 21:a key player in lymphocyte maturation. Crit Rev Immunol 24:239–50

    Article  PubMed  CAS  Google Scholar 

  • Okkenhaug K, and Vanhaesebroeck B (2003). PI3K in lymphocyte development, differentiation and activation. Nat Rev Immunol 3:317–30

    Article  PubMed  CAS  Google Scholar 

  • Parham P (2005). MHC class I molecules and KIRs in human history, health and survival. Nat Rev Immunol 5: 201–14

    Article  PubMed  CAS  Google Scholar 

  • Perussia B (2000). Signaling for cytotoxicity. Nat Immunol 1:372–4

    Article  PubMed  CAS  Google Scholar 

  • Peruzzi M, Wagtmann N, and Long EO (1996). A p70 killer inhibitory receptor specific for severalHLA-B allotypes discriminates among peptides bound to HLA-B*2705. J Exp Med 184:1585–90

    Article  PubMed  CAS  Google Scholar 

  • Rajagopalan S, Fu J, and Long EO (2001). Cutting edge: induction of IFN-γ production but not cytotoxicity by the killer cell Ig-like receptor KIR2DL4 (CD158d) in resting NK cells. J Immunol 167:1877–81

    PubMed  CAS  Google Scholar 

  • Rajagopalan S, and Long EO (1997). The direct binding of a p58 killer cell inhibitory receptor to human histocompatibility leukocyte antigen (HLA)-Cw4 exhibits peptide selectivity. J Exp Med 185:1523–8

    Article  PubMed  CAS  Google Scholar 

  • Raulet DH (2004). Interplay of natural killer cells and their receptors with the adaptive immune response. Nat Immunol 5:996–1002

    Article  PubMed  CAS  Google Scholar 

  • Ruggeri L, Capanni M, Urbani E, Perruccio K, Shlomchik WD, Tosti A, Posati S, Rogaia D, Frassoni F, Aversa F, Martelli MF, and Velardi A (2002). Effectiveness of donor natural killer cell alloreactivity in mismatched hematopoietic transplants. Science 295:2097–100.

    Article  PubMed  CAS  Google Scholar 

  • Sakisaka T, and Takai Y (2004). Biology and pathology of nectins and nectin-like molecules. Curr Opin Cell Biol 16:513–21

    Article  PubMed  CAS  Google Scholar 

  • Shibuya A, Campbell D, Hannum C, Yssel H, Franz-Bacon K, McClanahan T, Kitamura T, Nicholl J, Sutherland GR, Lanier LL, and Phillips JH (1996). DNAM-1, a novel adhesion molecule involved in the cytolytic function of T lymphocytes. Immunity 4:573–81

    Article  PubMed  CAS  Google Scholar 

  • Shibuya K, Lanier LL, Phillips JH, Ochs HD, Shimizu K, Nakayama E, Nakauchi H, and Shibuya A (1999). Physical and functional association of LFA-1 with DNAM-1 adhesion molecule. Immunity 11:615–23

    Article  PubMed  CAS  Google Scholar 

  • Sivori S, Falco M, Della Chiesa M, Carlomagno S, Vitale M, Moretta L, and Moretta A (2004). CpG and double-stranded RNA trigger human NK cells by Toll-like receptors: induction of cytokine release and cytotoxicity against tumors and dendritic cells. Proc Natl Acad Sci USA 101:10116–21

    Article  PubMed  CAS  Google Scholar 

  • Tassi I, Presti R, Kim S, Yokoyama WM, Giltillan S, and Colonna M (2005). Phospholipase C-gamma2 is a critical signaling mediator for murine NK cell activating receptors. J Immunol 175:749–754

    PubMed  CAS  Google Scholar 

  • Ting AT, Karnitz LM, Schoon RA, Abraham RT, and Leibson PJ (1992). Fc γ receptor activation induces the tyrosine phosphorylation of both phospholipase C (PLC)-γ1 and PLC-γ2 in natural killer cells. J Exp Med 176:1751–5

    Article  PubMed  CAS  Google Scholar 

  • Trotta R, Fettucciari K, Azzoni L, Abebe B, Puorro KA, Eisenlohr LC, and Perussia B (2000). Differential role of p38 and c-Jun N-terminal kinase 1 mitogen-activated protein kinases in NK cell cytotoxicity. J Immunol 165: 1782–9

    PubMed  CAS  Google Scholar 

  • Trotta R, Puorro KA, Paroli M, Azzoni L, Abebe B, Eisenlohr LC, and Perussia B (1998). Dependence of both spontaneous and antibody-dependent, granule exocytosis-mediated NK cell cytotoxicity on extracellular signal-regulated kinases. J Immunol 161:6648–56

    PubMed  CAS  Google Scholar 

  • Vales-Gomez M, Reyburn H, and Strominger J (2000). Interaction between the human NK receptors and their ligands. Crit Rev Immunol 20:223–44

    PubMed  CAS  Google Scholar 

  • Vales-Gomez M, Reyburn HT, Mandelboim M, and Strominger JL (1998). Kinetics of interaction of HLA-C ligands with natural killer cell inhibitory receptors. Immunity 9:892

    Article  Google Scholar 

  • Vance RE, Kraft JR, Altman JD, Jensen PE, and Raulet DH (1998). Mouse CD94/NKG2A Is a natural killer cell receptor for the nonclassical major histocompatibility complex (MHC) class i molecule Qa-1(b). J Exp Med 188:1841–8

    Article  PubMed  CAS  Google Scholar 

  • Veillette A, and Latour S (2003). The SLAM family of immune-cell receptors. Curr Opin Immunol 15:277–85

    Article  PubMed  CAS  Google Scholar 

  • Vilches C, and Parham P (2002). KIR: diverse, rapidly evolving receptors of innate and adaptive immunity. Annu Rev Immunol 20:217–51

    Article  PubMed  CAS  Google Scholar 

  • Vivier E, and Biron CA (2002). A pathogen receptor on natural killer cells. Science 296:1248–9

    Article  PubMed  CAS  Google Scholar 

  • Vivier E, and Daëron M (1997). Immunoreceptor tyrosine-based inhibition motifs (ITIMs). Immunol Today 18:286–91

    Article  PubMed  CAS  Google Scholar 

  • Vivier E, and Malissen B (2005). Innate and adaptive immunity: specificities and signaling hierarchies revisited. Nat Immunol 6:17–21

    Article  PubMed  CAS  Google Scholar 

  • Vivier E, Nunes JA, and Vely F (2004). Natural killer cell signaling pathways. Science 306:1517–9

    Article  PubMed  CAS  Google Scholar 

  • Vosshenrich CA, Ranson T, Samson SI, Corcuff E, Colucci F, Rosmaraki EE, and Di Santo JP (2005). Roles for common cytokine receptor gamma-chain-dependent cytokines in the generation, differentiation, and maturation of NK cell precursors and peripheral NK cells in vivo. J Immunol 174:1213–21

    PubMed  CAS  Google Scholar 

  • Vyas YM, Maniar H, and Dupont B (2002). Visualization of signaling pathways and cortical cytoskeleton in cytolytic and noncytolytic natural killer cell immune synapses. Immunol Rev 189:161–78

    Article  PubMed  CAS  Google Scholar 

  • Wang D, Feng J, Wen R, Marine JC, Sangster MY, Parganas E, Hoffmeyer A, Jackson CW, Cleveland JL, Murray PJ, and Ihle JN (2000). Phospholipase Cγ2 is essential in the functions of B cell and several Fc receptors. Immunity 13:25–35

    Article  PubMed  Google Scholar 

  • Wu J, Song Y, Bakker AB, Bauer S, Spies T, Lanier LL, and Phillips JH (1999). An activating immunoreceptor complex formed by NKG2D and DAP10. Science 285:730–2

    Article  PubMed  CAS  Google Scholar 

  • Wu LC, Tuot DS, Lyons DS, Garcia KC, and Davis MM (2002). Two-step binding mechanism for T-cell receptor recognition of peptide MHC. Nature 418:552–6

    Article  PubMed  CAS  Google Scholar 

  • Yokoyama WM (1998). Natural killer cell receptors. Curr Opin Immunol 10:298–305

    Article  PubMed  CAS  Google Scholar 

  • Zappacosta F, Borrego F, Brooks AG, Parker KC, and Coligan JE (1997). Peptides isolated from HLA-CW 0304 confer different degrees of protection from natural killer cell-mediated lysis. Proc. Natl Acad Sci USA 94:6313–8

    Article  PubMed  CAS  Google Scholar 

  • Zompi S, Gu H, and Colucci F (2004). The absence of Grb2-associated binder 2 (Gab2) does not disrupt NK cell development and functions. J Leukoc Biol 76:896–903

    Article  PubMed  CAS  Google Scholar 

  • Zompi S, Hamerman JA, Ogasawara K, Schweighoffer E, Tybulewicz VL, Di Santo JP, Lanier LL, and Colucci F (2003). NKG2D triggers cytotoxicity in mouse NK cells lacking DAP12 or Syk family kinases. Nat Immunol 4: 565–72

    Article  PubMed  CAS  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Lab of NK Cells and Innate Immunity, Centre d’Immunologie de Marseille-Luminy, INSERM-CNRS-Univ. Méditerranée, Campus de Luminy, 13288, Marseille cedex 09, France

    C. A. Stewart & E. Vivier

  2. Department of Pathology and Immunology, Washington University School of Medicine, St. Louis, MO, 63110, USA

    M. Colonna

Authors
  1. C. A. Stewart
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. E. Vivier
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. M. Colonna
    View author publications

    You can also search for this author in PubMed Google Scholar

Corresponding author

Correspondence to C. A. Stewart .

Editor information

Editors and Affiliations

  1. Atlanta, Georgia

    R.W. Compans

  2. Birmingham, Alabama

    M.D. Cooper

  3. Kyoto

    T. Honjo

  4. Philadelphia, Pennsylvania

    H. Koprowski

  5. Basel

    F. Melchers

  6. La Jolla, California

    M.B.A. Oldstone

  7. Oslo

    S. Olsnes

  8. Bethesda, Maryland

    M. Potter

  9. La Jolla, California

    P.K. Vogt

  10. Munich

    H. Wagner

  11. Laboratory of NK Cells and Innate Immunity, Centre d’Immunologie de Marseille-Luminy (CIML), CNRS-INSERM-Université de la Méditerranée, Campus de Luminy, Case 906, 13288, Marseille Cedex 09, France

    Eric Vivier DVM, PhD.

  12. Department of Pathology and Immunology, Washington University School of Medicine, West Building, Rooms 4724, Box 8118 660 South Euclid Ave, St. Louis, MO, 63110, USA

    Marco Colonna M.D.

Rights and permissions

Reprints and permissions

Copyright information

© 2006 Springer-Verlag Berlin Heidelberg

About this chapter

Cite this chapter

Stewart, C.A., Vivier, E., Colonna, M. (2006). Strategies of Natural Killer Cell Recognition and Signaling. In: Compans, R., et al. Immunobiology of Natural Killer Cell Receptors. Current Topics in Microbiology and Immunology, vol 298. Springer, Berlin, Heidelberg. https://doi.org/10.1007/3-540-27743-9_1

Download citation

Publish with us

Policies and ethics

Search

Navigation