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Regulatory T Cells in Experimental Colitis

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CD4+CD25+ Regulatory T Cells: Origin, Function and Therapeutic Potential

Part of the book series: Current Topics in Microbiology and Immunology ((CT MICROBIOLOGY,volume 293))

Abstract

Induction and maintenance of peripheral tolerance are important mechanisms to maintain the balance of the immune system. Growing evidence indicates that dysregulation of mucosal T cell responses may lead to loss of tolerance to commensal flora and to the development of inflammatory bowel diseases (IBD). Many studies suggest that active suppression of enteroantigen reactive cells mediated by regulatory T cells contributes to the maintenance of natural intestinal immune homeostasis. The use of the multiple animal models has not only improved our understanding of IBD, but also contributed to new suggestions of treatment strategies involving the use of regulatory T cells. The present review summarizes our current knowledge of regulatory T cells and their involvement in experimental IBD. The well-characterized SCID T cell transfer model and the naturally occurring regulatory CD4+CD25+ T cells are highlighted.

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Authors and Affiliations

  1. Department of Medical Anatomy, The Panum Institute, The University of Copenhagen, Blegdamsvej 3 C, 2200N, Copenhagen, Denmark

    M. Gad

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  1. M. Gad
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Editors and Affiliations

  1. Atlanta, Georgia

    R.W. Compans

  2. Birmingham, Alabama

    M.D. Cooper

  3. Kyoto

    T. Honjo

  4. Philadelphia, Pennsylvania

    H. Koprowski

  5. Basel

    F. Melchers

  6. La Jolla, California

    M.B.A. Oldstone  & P.K. Vogt  & 

  7. Oslo

    S. Olsnes

  8. Bethesda, Maryland

    M. Potter

  9. Munich

    H. Wagner

  10. Abteilung Entwicklungsimmunologie, Deutsches Krebsforschungszentrum Forschungsschwerpunkt Tumorimmunologie, Im Neuenheimer Feld 280, 69120, Heidelberg, Germany

    Bruno Kyewski

  11. Abteilung Immungenetik, Deutsches Krebsforschungszentrum Forschungsschwerpunkt Tumorimmunologie, Im Neuenheimer Feld 280, 69120, Heidelberg, Germany

    Elisabeth Suri-Payer

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Gad, M. (2005). Regulatory T Cells in Experimental Colitis. In: Compans, R., et al. CD4+CD25+ Regulatory T Cells: Origin, Function and Therapeutic Potential. Current Topics in Microbiology and Immunology, vol 293. Springer, Berlin, Heidelberg. https://doi.org/10.1007/3-540-27702-1_9

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