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CD4+CD25+ Regulatory T Cells: Origin, Function and Therapeutic Potential pp 1–23Cite as

Selection of CD4+CD25+ Regulatory T Cells by Self-Peptides

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Part of the book series: Current Topics in Microbiology and Immunology ((CT MICROBIOLOGY,volume 293))

Abstract

Regulatory T cells have been shown to prevent the development of autoimmune disease, and can modulate immune responses during infections or following tissue transplantation. Recently, the processes by which CD4+CD25+ regulatory T cells are produced during immune repertoire formation have begun to be elucidated. This review focuses on the role of self-peptides in mediating CD4+CD25+ regulatory T cell selection in the thymus. How self-peptides continue to have an important influence on the accumulation of CD4+CD25+ regulatory T cells in the periphery is also discussed.

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Authors and Affiliations

  1. The Wistar Institute, 3601 Spruce Street, Philadelphia, PA, 19104, USA

    C. Cozzo, M. A. Lerman, A. Boesteanu, J. Larkin III & A. J. Caton

  2. Signal Transduction Laboratory, Abrahamson Family Cancer Research Institute, University of Pennsylvania, Philadelphia, PA, 19104, USA

    M. S. Jordan

Authors
  1. C. Cozzo
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  2. M. A. Lerman
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  3. A. Boesteanu
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  4. J. Larkin III
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  5. M. S. Jordan
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  6. A. J. Caton
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Editor information

Editors and Affiliations

  1. Atlanta, Georgia

    R.W. Compans

  2. Birmingham, Alabama

    M.D. Cooper

  3. Kyoto

    T. Honjo

  4. Philadelphia, Pennsylvania

    H. Koprowski

  5. Basel

    F. Melchers

  6. La Jolla, California

    M.B.A. Oldstone  & P.K. Vogt  & 

  7. Oslo

    S. Olsnes

  8. Bethesda, Maryland

    M. Potter

  9. Munich

    H. Wagner

  10. Abteilung Entwicklungsimmunologie, Deutsches Krebsforschungszentrum Forschungsschwerpunkt Tumorimmunologie, Im Neuenheimer Feld 280, 69120, Heidelberg, Germany

    Bruno Kyewski

  11. Abteilung Immungenetik, Deutsches Krebsforschungszentrum Forschungsschwerpunkt Tumorimmunologie, Im Neuenheimer Feld 280, 69120, Heidelberg, Germany

    Elisabeth Suri-Payer

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Cozzo, C., Lerman, M.A., Boesteanu, A., Larkin, J., Jordan, M.S., Caton, A.J. (2005). Selection of CD4+CD25+ Regulatory T Cells by Self-Peptides. In: Compans, R., et al. CD4+CD25+ Regulatory T Cells: Origin, Function and Therapeutic Potential. Current Topics in Microbiology and Immunology, vol 293. Springer, Berlin, Heidelberg. https://doi.org/10.1007/3-540-27702-1_1

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