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Developmental Biology of Fibroblasts and Neoplastic Disease

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Developmental Biology of Neoplastic Growth

Part of the book series: Progress in Molecular and Subcellular Biology ((PMSB,volume 40))

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References

  • Adam L, Crépin M, Lelong J-C, Spanakis E, Israël L (1994) Selective interactions between mammary epithelial cells and fibroblasts in co-culture. Int J Cancer 59:262–268

    PubMed  Google Scholar 

  • Allinen M, Beroukhim R, Cai L, Brennan C, Lahti-Domenici J, Huang H, Portet D, Hu M, Chin L, Richardson A, Schnitt S, Sellers WR, Polyak K (2004) Molecular characterization of the tumor microenvironment in breast cancer. Cancer Cell 6:17–32

    Article  PubMed  Google Scholar 

  • Barth PJ, Ramaswany A, Moll R (2002a) CD34+ fibrocytes in normal cervical stroma, cervical intraepithelial neoplasia III, and invasive squamous cell carcinoma of the cervix uteri. Virchows Arch 441:564–568

    Article  PubMed  Google Scholar 

  • Barth PJ, Ebrahimsade S, Hellinger A, Moll R (2002b) CD34+ fibrocytes in neoplastic pancreatic lesions. Virchows Arch 440:128–133

    Article  PubMed  Google Scholar 

  • Barth PJ, Ebrahimsade S, Ramaswamy A, Moll R (2002c) CD34+ fibrocytes in invasive ductal carcinoma in situ, and benign breast lesions. Virchows Arch 440:298–303

    Article  PubMed  Google Scholar 

  • Beaupain R (1999) A method for three-dimensional coculture of cancer cells combined to any other type of cells maintained organotypically. Methods Cell Sci 21:25–30

    Article  PubMed  Google Scholar 

  • Berndt A, Koshmel H, Mandel U, Gabler U, Luo X, Celeda D, Zardi L, Katenkamp D (1995) TGFß and bFGF synthesis and localization in Dupuytren's disease (nodular palmar fibromatosis) relative to cellular activity, myofibroblast phenotype and oncofetal variants of fibronection. Histochem J 27:1014–1020

    Article  PubMed  Google Scholar 

  • Bissell MJ, Rizki A, Mian IS (2003) Tissue architecture: the ultimate regulator of breast epithelial function. Curr Opin Cell Biol 15:753–762

    Article  PubMed  Google Scholar 

  • Briard D, Brouty-Boyé D, Azzarone B, Jasmin C (2002) Fibroblasts from human spleen regulate NK cell differentiation from blood CD34 (+) progenitors via cell surface IL-15. J Immunol 168:4326–4332

    PubMed  Google Scholar 

  • Brouty-Boyé D, Magnien V (1994) Myofibroblast and concurrent ED-B fibronectin phenotype in human stromal cells cultured from non-malignant and malignant breast tissue. Eur J Cancer 30A:66–73

    PubMed  Google Scholar 

  • Brouty-Boyé D, Raux H (1993) Differential influence of stromal fibroblasts from different breast tissue on human breast tumour cell growth in nude mice. Anticancer Res 13:1087–1090

    PubMed  Google Scholar 

  • Brouty-Boyé D, Tucker RW, Folkman J (1980) Transformed and neoplastic phenotype: reversibility during culture by cell density and cell shape. Int J Cancer 26:501–507

    PubMed  Google Scholar 

  • Brouty-Boyé D, Raux H, Chraïbi-Hajji F, Magnien V, Sallé V (1991a) Sorting of subclasses of epithelial and fibroblastic cells in primary cultures of benign and malignant breast tissues by use of fluorescent probes monospecific for the cytoskeleton and the extracellular matrix. J Cell Pharmacol 3:103–110

    Google Scholar 

  • Brouty-Boyé D, Raux H, Azzarone B, Tamboise A, Tamboise E, Béranger S, Magnien V, Pihan I, Zardi L, Israël L (1991b) Fetal myofibroblast-like cells isolated from post-radiation fibrosis in human breast cancer. Int J Cancer 47:697–702

    PubMed  Google Scholar 

  • Brouty-Boyé D, Mainguené C, Magnien V, Israël L, Beaupain R (1994) Fibroblast-mediated differentiation in human breast carcinoma cells (MCF-7) grown as nodules in vitro. J Int Cancer 56: 731–735

    Google Scholar 

  • Brouty-Boyé D, Doucet C, Clay D, Le Bousse-Kerdilès M-C, Lampidis TJ, Azzarone B (1998) Phenotypic diversity in human fibroblasts from myelometaplasic and non-myelometaplasic hematopoietic tissues. Int J Cancer 76:767–773

    Article  PubMed  Google Scholar 

  • Brouty-Boyé D, Briard D, Azzarone B, Le Bousse-Kerdilès M-C, Clay D, Pottin-Clémenceau C, Jasmin C (2001) Effects of human fibroblasts from myelometaplasic and non-myelometaplasic hematopoietic tissues on CD34+ stem cells. Int J Cancer 92:484–488

    Article  PubMed  Google Scholar 

  • Brouty-Boyé D, Pottin-Clémenceau C, Doucet C, Jasmin C, Azzarone B (2002) Chemokines and CD40 expression in human fibroblasts. Eur J Immunol 30:914–919

    Google Scholar 

  • Bucala R, Spiegel LA, Chesney J, Hogan M, Cerami A (1994) Circulating fibrocytes define a new leukocyte subpopulation that mediates tissue repair. Mol Med 1:71–81

    PubMed  Google Scholar 

  • Chang HY, Chi J-T, Dudoit S, Bondre C, van de Rijn M, Botstein D, Brown PO (2002) Diversity, topographic differentiation, and positional memory in human fibroblasts. Proc Natl Acad Sci USA 99:12877–12882

    Article  PubMed  Google Scholar 

  • Chang HY, Sneddon JB, Alizadeh AA, Sood R, West RB, Montgomery K, Chi JT, van de Rijn M, Botstein D, Brown PO (2004) Gene expression signature of fibroblast serum response predicts human progression: similarities between tumors and wound. PLS Biol 2:1–9

    Article  Google Scholar 

  • Chou Y-H, Khuon S, Herrmann H, Goldman RD (2003) Nestin promotes the phosphorylation-dependent disassembly of vimentin intermediate filaments during mitosis. Mol Biol Cell 14:1468–1478

    Article  PubMed  Google Scholar 

  • Desmoulière A, Rubbia-Brandt L, Abdiu A, Walz T, Macieira-Coelho A, Gabbiani G (1992) Alpha-smooth muscle actin is expressed in a subpopulation of cultured and cloned fibroblasts and is modulated by gamma-interferon. Exp Cell Res 20:64–73

    Article  Google Scholar 

  • Fiorito S, Magrini L, Adrey J, Maihlé D, Brouty-Boyé D (2005) Inflammatory status and cartilage regenerative potential of synovial fibroblasts from patients with osteoarthritis and chondropathy. Rheumatol (44:164–171)

    Article  Google Scholar 

  • Friedman SL (2000) Molecular regulation of hepatic fibrosis, an integrated cellular response to tissue injury. J Biol Sci 275:2247–2250

    Google Scholar 

  • Gabbiani G, Ryan GB, Majno G (1971) Presence of modified fibroblasts in granulation tissue and their possible role in wound contraction. Experientia 27:549–550

    Article  PubMed  Google Scholar 

  • Grinnell F (2003) Fibroblast biology in three-dimensional collagen matrices. Trends Cell Biol 13:264–269

    Article  PubMed  Google Scholar 

  • Hinz B, Gabbiani G (2003) Mechanisms of force generation and transmission by myofibroblasts. Curr Opin Biotech 14:538–546

    Article  PubMed  Google Scholar 

  • Iyer VR, Eisen MB, Ross DT, Schuler G, Moore T, Lee JCF, Trent JM, Staut LM, Hudson J Jr, Boguski MS, Lashkari D, Shalon D, Botstein D, Brown PO (1999) The transcriptional program in the response of human fibroblasts to serum. Science 283:83–87

    Article  PubMed  Google Scholar 

  • Jacks T, Weinberg RA (2002) Taking the study of cancer cells to a new dimension. Cell 111:923–925

    Article  PubMed  Google Scholar 

  • Javazon EH, Beggs KJ, Flake AW (2004) Mesenchymal stem cells: paradoxes of passaging. Exp Hematol 32:414–425

    Article  PubMed  Google Scholar 

  • Kaczmarek J, Castellani P, Nicolo G, Spina B, Allemani G, Zardi L (1994) Distribution of oncofetal fibronectin isoforms in normal, hyperplasic and neoplastic human breast tissues. Int J Cancer 59:11–16

    PubMed  Google Scholar 

  • Kalluri R, Neilson EG (2003) Epithelial-mesenchymal transition and its implications for fibrosis. J Clin Invest 112:1776–1784

    Article  PubMed  Google Scholar 

  • Klein T, Ling Z, Heimberg H, Madsen OD, Heller RS, Serup P (2003) Nestin is expressed in vascular endothelial cells in the adult human pancreas. J Hist Cytochem 51:697–706

    Google Scholar 

  • Koshmel H, Berndt A, Strassburger S, Borsi L, Rouselle P, Mandel U, Hyckel P, Zardi L, Katenkamp D (1999) Distribution of laminin and fibronectin isoforms in oral mucosa and oral squamous cell carcinoma. Br J Cancer 81:1071–1079

    Article  PubMed  Google Scholar 

  • Kriegsmann J, Berndt A, Hansen T, Borsi L, Zardi L, Brauer R, Petrow PK, Otto M, Kirkpatrick CJ, Gay S, Kosehl H (2004) Expression of fibronectin variants and oncofetal glycosylated fibronectin in the synovial membranes of patients with arthritis and osteoarthritis Rheumatol Int 1:25–33

    Article  Google Scholar 

  • Kurose K, Gilley K, Matsumoto S, Watson PH, Zhou X-P, Eng C (2002) Frequent somatic mutations in PTEN and TP53 are mutually exclusive in the stroma of breast carcinomas. Nature Gen 32:355–357

    Article  Google Scholar 

  • Labat ML (2001) Stem cells and the promise of eternal youth: embryonic versus adult stem cells. Biomed Pharmacother 55:179–185

    Article  PubMed  Google Scholar 

  • Labat ML, Milhaud G, Pouchelet M, Boireau P (2000) On the track of a human circulating mesenchymal stem cell of neural crest origin. Biomed Pharmacother 54:146–162

    Article  PubMed  Google Scholar 

  • Labat ML, Bringuier AF, Arys-Philippart C, Arys A, Wellens F. (1994) Monocytic origin of fibrosis. In vitro transformation of HLA-DR monocytes into neo-fibroblasts: inhibitory effect of all-trans retinoic acid on this process. Biomed Pharmacother 48:103–11

    Article  PubMed  Google Scholar 

  • Liu L, Brouty-Boyé D (1994) Action of various growth factors and cytokines on α-smooth muscle actin expression by fibroblasts from postradiation breast fibrosis. Proc Am Assoc Cancer Res 35:648

    Google Scholar 

  • Messam CA, Hou J, Major EO (2000) Coexpression of nestin in neural and glial cells in the developing human CNS defined by a human-specific anti-nestin antibody Exp Neurol 161:585–596

    Article  PubMed  Google Scholar 

  • Metz CN (2003) Fibrocytes: a unique cell population implicated in wound healing CMLS. Cell Mol Life Sci 60:1342–1350

    Article  PubMed  Google Scholar 

  • Myers CA, Liu H, Lee E, Bissell MJ (2003) Three-dimensional cultures of human breast epithelial cells to achieve in vivo-like architecture and function. In: Celis J (ed) Cell biology: a laboratory handbook, 3rd edn. Elsevier Science, London (in press)

    Google Scholar 

  • Pankov R, Yamada KM (2002) Fibronectin at a glance. J Cell Sci 115:3861–3866

    Article  PubMed  Google Scholar 

  • Pasco S, Ramont L, Maquart F-X, Monboisse J-C (2004) Control of melanoma progression by various matrikines from basement membrane macromolecules. Oncol Hematol 49:221–233

    Google Scholar 

  • Peterson OW, Nielson HL, Gudjonson T, Villadsen R, Ronnov-Jessen L, Bissell MJ (2001) The plasticity of human breast carcinoma cells is more than epithelial to mesenchymal conversion. Breast Cancer Res 3:213–214

    Article  PubMed  Google Scholar 

  • Pilling D, Buckley CD, Salmon M, Gomer RH (2003) Inhibition of fibrocyte differentiation by serum amyloid P. J Immunol 171:5537–5546

    PubMed  Google Scholar 

  • Ronnov-Jessen L, Petersen OW (1996) A function for filamentous α-smooth muscle actin: retardation of motility in fibroblasts. J Cell Biol 134:67–80

    Article  PubMed  Google Scholar 

  • Sappino AP, Schürch W, Gabbiani G (1990) Biology of disease. Differentiation repertoire of fibroblastic cells: expression of cytoskeletal proteins as marker of phenotypic modulations. Lab Invest 63:144–161

    PubMed  Google Scholar 

  • Schor SL, Schor AM (2001) Tumour-stroma interactions. henotypic and genetic alterations in mammary stroma: implications for tumour progression. Breast Cancer Res 3:373–379

    Article  PubMed  Google Scholar 

  • Schor SL, Ellis IA, Sarah JJ, Baillie R, Seneviratne K, Clausen J, Motegi K, Vojtesek, B, Kankova K, Furrie E, Sales MJ, Schor AM, Kay RA (2003) Migration-stimulating factor: a genetically truncated onco-fetal fibronectin isoform expressed by carcinoma and tumor-associated stromal cells. Cancer Res 63:8827–8836

    PubMed  Google Scholar 

  • Schürch W, Seemayer TA, Lagacé R (1981) Stromal myofibroblasts in primary invasive and metastatic carcinomas. A combined immunological, light and electron microscopic study. Virchows Arch A Pathol Anat Histol 391:125–139

    Article  PubMed  Google Scholar 

  • Skalli O, Schürch W, Seemayer T, Lagacé R, Montandon D, Pittet B, Gabbiani G (1989) Myofibroblasts from diverse pathologic settings are heterogeneous in their content of actin isoforms and intermediate filament proteins. Lab Invest 60:275–285

    PubMed  Google Scholar 

  • Spanakis E, Brouty-Boyé D (1995) Quantitative variation of proto-oncogene and cytokine gene expression in isolated breast fibroblasts. Int J Cancer 61:698–705

    PubMed  Google Scholar 

  • Spanakis E, Brouty-Boyé D (1997) Discrimination of fibroblast subtypes by multivariate analysis of gene expression. Int J Cancer 71:402–409

    Article  PubMed  Google Scholar 

  • Steiniger B, Barth P (2000) Microanatomy and function of the spleen. Adv Anat Embryol Cell Biol 151(III–IX):1–101

    Google Scholar 

  • Steiniger B, Barth P, Hellinger A (2001) The perifollicular and marginal zones of the human splenic white pulp: do fibroblasts guide lymphocyte immigration? Am J Pathol 159:501–512

    PubMed  Google Scholar 

  • Strutz F, Muller GA (2000) Transdifferentiation comes of age. Nephrol Dial Transplant 15:1729–1731

    Article  PubMed  Google Scholar 

  • Thierry J-P (2002) Epithelial-mesenchymal transitions in tumour progression. Nature Rev 2:442–454

    Article  Google Scholar 

  • Tomasek JJ, Gabbiani G, Hinz B, Chaponnier C, Browns RA (2002) Myofibroblasts and mechano-regulation of connective tissue remodelling. Nature Rev 3:349–362

    Article  Google Scholar 

  • Van den Hooff A (1986) Connective tissue as active participants in the process of malignant growth. Anticancer Res 6:775–780

    PubMed  Google Scholar 

  • Van den Hooff A (1988) Stromal involvement in malignant growth. In: Klein G, Weinberg S (eds) Advances in cancer research, vol 50. Academic Press, London, pp 159–196

    Google Scholar 

  • Vescovi AL, Galli R, Gritti A (2001) The neural stem cells and their transdifferentiation capacity. Biomed Pharmacother 55:201–205

    PubMed  Google Scholar 

  • Woodbury D, Schwartz EJ, Prockop DJ, Black IB (2000) Adult rat and human bone marrow stromal cells differentiate into neurons. J Neurosci Res 61:364–370

    Article  PubMed  Google Scholar 

  • Zhao Y, Glesne D, Huberman E (2003) A human peripheral blood monocyte-derived subset acts as pluripotent stem cells. Proc Natl Acad Sci USA 100:2426–2431

    PubMed  Google Scholar 

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Brouty-Boyé, D. (2005). Developmental Biology of Fibroblasts and Neoplastic Disease. In: Macieira-Coelho, A. (eds) Developmental Biology of Neoplastic Growth. Progress in Molecular and Subcellular Biology, vol 40. Springer, Berlin, Heidelberg. https://doi.org/10.1007/3-540-27671-8_3

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